PMC Links for GEO Profiles (Select 114880391) - PMC

Select item 111095831.

Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury

Faraaz A. Shah, Harinath Bahudhanapati, Mao Jiang, Mohammadreza Tabary, Rick van der Geest, Nathanial J. Tolman, Megan Kochin, Zeyu Xiong, Nameer Al-Yousif, Khaled Sayed, Panayiotis V. Benos, Kristen Raffensperger, John Evankovich, Matthew D. Neal, Mark E. Snyder, Oliver Eickelberg, Prabir Ray, Charles Dela Cruz, Jessica Bon, Bryan J. McVerry, Adam C. Straub, Michael J. Jurczak, Tomeka L. Suber, Yingze Zhang, Kong Chen, Georgios D. Kitsios, Janet S. Lee, Jonathan K. Alder, William G. Bain

Am J Respir Cell Mol Biol. 2024 May 1; 70(5): 379–391. Published online 2024 Feb 1. doi: 10.1165/rcmb.2023-0429OC

PMCID:: PMC11109583

Abstract Article PDF–2.0M

Select item 110775892.

GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation

Katja Baur, Şeydanur Şan, Gabriele Hölzl-Wenig, Claudia Mandl, Andrea Hellwig, Francesca Ciccolini

Life Sci Alliance. 2024 Jul; 7(7): e202302384. Published online 2024 May 7. doi: 10.26508/lsa.202302384

PMCID:: PMC11077589

Abstract Article PDF–3.0M

Select item 107846533.

Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis

Dongdong Wang, Maria Joy Therese Jabile, Junfeng Lu, Logan K. Townsend, Celina M. Valvano, Jaya Gautam, Battsetseg Batchuluun, Evangelia E. Tsakiridis, James S.V. Lally, Gregory R. Steinberg

Diabetes. 2024 Jan; 73(1): 51–56. Published online 2023 Oct 17. doi: 10.2337/db23-0495

PMCID:: PMC10784653

Abstract Article PDF–40M

Select item 103227164.

GDF15 promotes weight loss by enhancing energy expenditure in muscle

Dongdong Wang, Logan K. Townsend, Geneviève J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A. Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A. Pileggi, Sonia Rehal, Eric M. Desjardins, Evangelia E. Tsakiridis, James S. V. Lally, Emma Sara Juracic, A. Russell Tupling, Hertzel C. Gerstein, Guillaume Paré, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J. Hawke, John R. Speakman, Denis P. Blondin, Graham P. Holloway, Sebastian Beck Jørgensen, Gregory R. Steinberg

Nature. 2023; 619(7968): 143–150. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06249-4

PMCID:: PMC10322716

Abstract Article PDF–26M

Select item 101107085.

Neither glucagon-like peptide 1 receptors nor GDNF family receptor α-like neurons are required for aversive or anorectic response to deoxynivalenol (vomitoxin)

Anita R. Patel, Henriette Frikke-Schmidt, Paul V. Sabatini, Alan C. Rupp, Darleen A. Sandoval, Martin G. Myers, Jr., Randy J. Seeley

Am J Physiol Regul Integr Comp Physiol. 2023 May 1; 324(5): R635–R644. Published online 2023 Mar 13. doi: 10.1152/ajpregu.00189.2022

PMCID:: PMC10110708

Abstract Article

Select item 98680836.

The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice

Brandon Chelette, Chinenye L Chidomere, Robert Dantzer

Brain Behav Immun. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Brain Behav Immun. 2023 Feb; 108: 45–54. Published online 2022 Nov 24. doi: 10.1016/j.bbi.2022.11.008

PMCID:: PMC9868083

Abstract Article PDF–1.7M

Select item 94497057.

Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior

Carla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, Susanne Klaus, Mario Ost

Life Sci Alliance. 2022 Nov; 5(11): e202201495. Published online 2022 Sep 6. doi: 10.26508/lsa.202201495

PMCID:: PMC9449705

Abstract Article PDF–2.4M

Select item 92608808.

A brainstem circuit for nausea suppression

Chuchu Zhang, Lindsay K. Vincelette, Frank Reimann, Stephen D. Liberles

Cell Rep. Author manuscript; available in PMC 2022 Jul 7.

Published in final edited form as: Cell Rep. 2022 Jun 14; 39(11): 110953. doi: 10.1016/j.celrep.2022.110953

PMCID:: PMC9260880

Abstract Article PDF–2.2M

Select item 88705219.

Camptothecin effectively treats obesity in mice through GDF15 induction

Jun Feng Lu, Meng Qing Zhu, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei Wu

PLoS Biol. 2022 Feb; 20(2): e3001517. Published online 2022 Feb 24. doi: 10.1371/journal.pbio.3001517

PMCID:: PMC8870521

Abstract Article PDF–3.8M

Select item 879939010.

LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice

Anita R. Patel, Henriette Frikke-Schmidt, Olivier Bezy, Paul V. Sabatini, Nikolaj Rittig, Niels Jessen, Martin G. Myers, Jr., Randy J. Seeley

Am J Physiol Gastrointest Liver Physiol. 2022 Feb 1; 322(2): G247–G255. Published online 2021 Dec 22. doi: 10.1152/ajpgi.00146.2021

PMCID:: PMC8799390

Abstract Article

Select item 863398711.

Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity

Masato Miyake, Jun Zhang, Akihiro Yasue, Satoshi Hisanaga, Kazue Tsugawa, Hiroshi Sakaue, Miho Oyadomari, Hiroshi Kiyonari, Seiichi Oyadomari

iScience. 2021 Dec 17; 24(12): 103448. Published online 2021 Nov 15. doi: 10.1016/j.isci.2021.103448

PMCID:: PMC8633987

Abstract Article PDF–3.8M

Select item 792365812.

GFRAL-expressing neurons suppress food intake via aversive pathways

Paul V. Sabatini, Henriette Frikke-Schmidt, Joe Arthurs, Desiree Gordian, Anita Patel, Alan C. Rupp, Jessica M. Adams, Jine Wang, Sebastian Beck Jørgensen, David P. Olson, Richard D. Palmiter, Martin G. Myers, Jr, Randy J. Seeley

Proc Natl Acad Sci U S A. 2021 Feb 23; 118(8): e2021357118. Published online 2021 Feb 15. doi: 10.1073/pnas.2021357118

PMCID:: PMC7923658

Abstract Article PDF–1.6M

Select item 786488713.

Area postrema cell types that mediate nausea-associated behaviors

Chuchu Zhang, Judith A. Kaye, Zerong Cai, Yandan Wang, Sara L. Prescott, Stephen D. Liberles

Neuron. Author manuscript; available in PMC 2022 Feb 3.

Published in final edited form as: Neuron. 2021 Feb 3; 109(3): 461–472.e5. Published online 2020 Dec 4. doi: 10.1016/j.neuron.2020.11.010

PMCID:: PMC7864887

Abstract Article PDF–2.7M

Select item 741048814.

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman

eLife. 2020; 9: e55164. Published online 2020 Jul 29. doi: 10.7554/eLife.55164

PMCID:: PMC7410488

Abstract Article PDF–1.7M

Select item 723483915.

GDF15 mediates the effects of metformin on body weight and energy balance

Anthony P Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A. Goldspink, Emily L. Miedzybrodzka, Adam R Konopka, Raul Ruiz Esponda, Jeffrey T.-J. Huang, Y. C. Loraine Tung, Sergio Rodriguez-Cuenca, Rute A. Tomaz, Heather P. Harding, Audrey Melvin, Giles S.H. Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, K. Sreekumaran Nair, Nicholas J. Wareham, David Ron, Fiona M. Gribble, Frank Reimann, Naveed Sattar, David B. Savage, Bernard B. Allan, Stephen O'Rahilly

Nature. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Nature. 2020 Feb 1; 578(7795): 444–448. Published online 2019 Dec 25. doi: 10.1038/s41586-019-1911-y

Correction in:: Nature. 2020 Feb 13

PMCID:: PMC7234839

Abstract Article PDF–3.8M

Select item 640736516.

GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

Henriette Frikke-Schmidt, Karin Hultman, Joseph W. Galaske, Sebastian B. Jørgensen, Martin G. Myers, Jr., Randy J. Seeley

Mol Metab. 2019 Mar; 21: 13–21. Published online 2019 Jan 14. doi: 10.1016/j.molmet.2019.01.003

PMCID:: PMC6407365

Abstract Article PDF–2.3M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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