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Select item 111451461.

YTHDC1‐dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple‐negative breast cancer

Xi Shen, Jianxin Zhong, Pan Yu, Feng Liu, Haoran Peng, Nianyong Chen

Cancer Sci. 2024 Jun; 115(6): 1881–1895. Published online 2024 Apr 3. doi: 10.1111/cas.16137

PMCID:: PMC11145146

Abstract Article PDF–18M

Select item 110922622.

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m⁶A reader YTHDC1 protein degradation

Yi Yang, Yingwen Zhang, Guoyu Chen, Bowen Sun, Fei Luo, Yijin Gao, Haizhong Feng, Yanxin Li

J Exp Clin Cancer Res. 2024; 43: 141. Published online 2024 May 14. doi: 10.1186/s13046-024-03040-9

PMCID:: PMC11092262

Abstract Article PDF–3.7M

Select item 110740423.

Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia

Tianping Bao, Xiangye Liu, Jian Hu, Mengmeng Ma, Jingyan Li, Linxia Cao, Bingrui Yu, Huaiping Cheng, Sai Zhao, Zhaofang Tian

Inflammation. 2024; 47(2): 469–482. Published online 2023 Nov 2. doi: 10.1007/s10753-023-01923-1

PMCID:: PMC11074042

Abstract Article PDF–6.5M

Select item 109950984.

YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus

Danhong Dong, Jiangpeng Wei, Weidong Wang, Haikun Zhou, Liu Hong, Gang Ji, Xisheng Yang

Cell Biol Toxicol. 2024; 40(1): 19. Published online 2024 Apr 4. doi: 10.1007/s10565-024-09859-4

PMCID:: PMC10995098

Abstract Article PDF–8.7M

Select item 107649585.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 106842586.

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis

Meng Zhou, Yuzhen Liu, Haoxiang Xu, Xu Chen, Nana Zheng, Zhimin Duan, Yiping Ge, Dongqing Li, Tong Lin, Rong Zeng, Qing Chen, Min Li

J Innate Immun. 2023 Jan-Dec; 15(1): 822–835. Published online 2023 Oct 30. doi: 10.1159/000534704

PMCID:: PMC10684258

Abstract Article PDF–1.7M

Select item 105658767.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105357078.

Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis

Xiaogang Wang, Qianyu Chen, Ziqian Bing, Shizhen Zhou, Zhen Xu, Yayi Hou, Yue Zhao, Shuli Zhao, Tingting Wang

Int J Biol Sci. 2023; 19(14): 4672–4688. Published online 2023 Aug 28. doi: 10.7150/ijbs.81595

PMCID:: PMC10535707

Abstract Article PDF–13M

Select item 103342759.

YTHDC1 positively regulates PTEN expression and plays a critical role in cisplatin resistance of bladder cancer

Yinjie Su, Bo Wang, Jian Huang, Ming Huang, Tianxin Lin

Cell Prolif. 2023 Jul; 56(7): e13404. Published online 2023 Apr 17. doi: 10.1111/cpr.13404

PMCID:: PMC10334275

Abstract Article PDF–8.5M

Select item 1031808310.

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression

Bin Yan, Xurui Li, Mou Peng, Yali Zuo, Yinhuai Wang, Pian Liu, Weigang Ren, Xin Jin

Exp Mol Med. 2023 Jun; 55(6): 1145–1158. Published online 2023 Jun 1. doi: 10.1038/s12276-023-00997-z

PMCID:: PMC10318083

Abstract Article PDF–7.3M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1014656912.

N⁶-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu, Ruifang Wang, Jiahui Zou, Shan Tian, Luyao Yu, Yuanbao Zhou, Ying Ran, Meilin Jin, Huanchun Chen, Hongbo Zhou

PLoS Pathog. 2023 Apr; 19(4): e1011305. Published online 2023 Apr 13. doi: 10.1371/journal.ppat.1011305

PMCID:: PMC10146569

Abstract Article PDF–3.0M

Select item 995044713.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993580914.

The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection

Fanxing Yin, Kun Liu, Wanfu Peng, Deying Jiang, Hao Zhang, Panpan Guo, Yinhao Wu, Xiaoxu Zhang, Chenxi Sun, Yaxuan Wang, Hecheng Wang, Yanshuo Han

Oxid Med Cell Longev. 2023; 2023: 3918393. Published online 2023 Feb 9. doi: 10.1155/2023/3918393

PMCID:: PMC9935809

Abstract Article PDF–1.7M

Select item 979798815.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 976969816.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 962912117.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 944065318.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 938276419.

YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway

Wei Li, Kun Ye, Xurui Li, Xinlin Liu, Mou Peng, Fang Chen, Wei Xiong, Yinhuai Wang, Liang Zhu

J Exp Clin Cancer Res. 2022; 41: 250. Published online 2022 Aug 17. doi: 10.1186/s13046-022-02460-9

PMCID:: PMC9382764

Abstract Article PDF–15M

Select item 929024120.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7