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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111600352.

Low concentrations of doxorubicin sensitizes human solid cancer cells to tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐receptor (R) 2‐mediated apoptosis by inducing TRAIL‐R2 expression

Xiu‐Xian Wu, Xing‐Hua Jin, Yu Zeng, Ahmed Mamdouh Abd El Hamed, Yoshiyuki Kakehi

Cancer Sci. 2007 Dec; 98(12): 1969–1976. Published online 2007 Oct 8. doi: 10.1111/j.1349-7006.2007.00632.x

PMCID:: PMC11160035

Abstract Article PDF–628K

Select item 111587113.

Knockdown of c‐FLIP_L enhanced AD5‐10 anti‐death receptor 5 monoclonal antibody‐induced apoptosis in human lung cancer cells

Feng Chen, Juntang Guo, Yaxi Zhang, Yu Zhao, Naikang Zhou, Shilian Liu, Yanxin Liu, Dexian Zheng

Cancer Sci. 2009 May; 100(5): 940–947. Published online 2009 Feb 19. doi: 10.1111/j.1349-7006.2009.01119.x

Correction in:: Cancer Sci. 2009 Dec; 100(12): 2469.

PMCID:: PMC11158711

Abstract Article PDF–2.1M

Select item 111586154.

DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL‐mediated apoptosis via up‐regulation of TRAIL‐R2/DR5 and caspase‐8

Satoshi Kurita, Hajime Higuchi, Yoshimasa Saito, Nobuhiro Nakamoto, Hiromasa Takaishi, Shinichiro Tada, Hidetsugu Saito, Gregory J. Gores, Toshifumi Hibi

Cancer Sci. 2010 Jun; 101(6): 1431–1439. Published online 2010 Mar 13. doi: 10.1111/j.1349-7006.2010.01565.x

PMCID:: PMC11158615

Abstract Article PDF–539K

Select item 109168665.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 106990996.

Death receptor 5 promotes tumor progression in gastric cancer

Junbing Chen, Lin Li, Longtao Huangfu, Hong Du, Xin Ji, Xiaofang Xing, Jiafu Ji

FEBS Open Bio. 2023 Dec; 13(12): 2375–2388. Published online 2023 Nov 14. doi: 10.1002/2211-5463.13725

PMCID:: PMC10699099

Abstract Article PDF–7.4M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100167088.

HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

Mohamed I. Khalil, Canchai Yang, Lexi Vu, Smriti Chadha, Harrison Nabors, Craig Welbon, Claire D. James, Iain M. Morgan, William C. Spanos, Dohun Pyeon

PLoS Pathog. 2023 Mar; 19(3): e1011171. Published online 2023 Mar 3. doi: 10.1371/journal.ppat.1011171

PMCID:: PMC10016708

Abstract Article PDF–4.7M

Select item 95093379.

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5

Seon Min Woo, Seok Kim, Seung Un Seo, Shin Kim, Jong-Wook Park, Gyeonghwa Kim, Yu-Ra Choi, Keun Hur, Taeg Kyu Kwon

Cell Death Dis. 2022 Sep; 13(9): 821. Published online 2022 Sep 24. doi: 10.1038/s41419-022-05271-0

PMCID:: PMC9509337

Abstract Article PDF–4.2M

Select item 940925510.

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer

Rocío Mora-Molina, Abelardo López-Rivas

Int J Mol Sci. 2022 Aug; 23(16): 8987. Published online 2022 Aug 12. doi: 10.3390/ijms23168987

PMCID:: PMC9409255

Abstract Article PDF–2.3M

Select item 923009311.

Induction of DR5-Dependent Apoptosis by PGA₂ through ATF4-CHOP Pathway

Kyeong-Min Park, Ji-Young Park, Jaehyuk Pyo, Sun-Young Lee, Ho-Shik Kim

Molecules. 2022 Jun; 27(12): 3804. Published online 2022 Jun 13. doi: 10.3390/molecules27123804

PMCID:: PMC9230093

Abstract Article PDF–1.4M

Select item 855290712.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 832569413.

TRAIL-receptor 2—a novel negative regulator of p53

Anna Willms, Hella Schupp, Michelle Poelker, Alshaimaa Adawy, Jan Frederik Debus, Torsten Hartwig, Tim Krichel, Jürgen Fritsch, Steven Singh, Henning Walczak, Silvia von Karstedt, Heiner Schäfer, Anna Trauzold

Cell Death Dis. 2021 Aug; 12(8): 757. Published online 2021 Jul 31. doi: 10.1038/s41419-021-04048-1

PMCID:: PMC8325694

Abstract Article PDF–6.7M

Select item 825725514.

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

Dongjin Jeong, Hye Sung Kim, Hye Young Kim, Min Jueng Kang, Hyeryeon Jung, Yumi Oh, Donghyun Kim, Jaemoon Koh, Sung-Yup Cho, Yoon Kyung Jeon, Eun Bong Lee, Seung Hyo Lee, Eui-Cheol Shin, Ho Min Kim, Eugene C Yi, Doo Hyun Chung

eLife. 2021; 10: e48840. Published online 2021 Jul 5. doi: 10.7554/eLife.48840

PMCID:: PMC8257255

Abstract Article PDF–3.9M

Select item 822997415.

Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai

Genes (Basel) 2021 Jun; 12(6): 864. Published online 2021 Jun 5. doi: 10.3390/genes12060864

PMCID:: PMC8229974

Abstract Article PDF–4.1M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 798036617.

Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2

Rengyun Liu, Jie Tan, Xiaopei Shen, Ke Jiang, Chaoqun Wang, Guangwu Zhu, Mingzhao Xing

Proc Natl Acad Sci U S A. 2021 Mar 16; 118(11): e2022779118. Published online 2021 Mar 8. doi: 10.1073/pnas.2022779118

PMCID:: PMC7980366

Abstract Article PDF–1.2M

Select item 797374818.

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

Yi An, Jun Jeon, Lillian Sun, Adeeb Derakhshan, Jianhong Chen, Sophie Carlson, Hui Cheng, Christopher Silvin, Xinping Yang, Carter Van Waes, Zhong Chen

Sci Rep. 2021; 11: 6392. Published online 2021 Mar 18. doi: 10.1038/s41598-021-85589-5

PMCID:: PMC7973748

Abstract Article PDF–4.2M

Select item 784873719.

Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy

Wentao Chen, Kurt Yun Mou, Paige Solomon, Rahul Aggarwal, Kevin K. Leung, James A. Wells

Proc Natl Acad Sci U S A. 2021 Jan 26; 118(4): e2018861118. Published online 2021 Jan 22. doi: 10.1073/pnas.2018861118

PMCID:: PMC7848737

Abstract Article PDF–1.2M

Select item 771408420.

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis

Máté János Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh

FEBS Open Bio. 2020 Dec; 10(12): 2771–2779. Published online 2020 Nov 13. doi: 10.1002/2211-5463.13017

PMCID:: PMC7714084

Abstract Article PDF–740K

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