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Select item 112251941.

UCHL3 promotes hepatocellular carcinoma progression by stabilizing EEF1A1 through deubiquitination

Jie Zhao, Qiang Huo, Ji Zhang, Kexiang Sun, Jinhui Guo, Feng Cheng, Xiaoge Hu, Qiuran Xu

Biol Direct. 2024; 19: 53. Published online 2024 Jul 4. doi: 10.1186/s13062-024-00495-w

PMCID:: PMC11225194

Abstract Article PDF–11M

Select item 109323662.

CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3

Gengchen Xie, Bo Lei, Zhijie Yin, Fei Xu, Xinghua Liu

Int J Mol Sci. 2024 Mar; 25(5): 2817. Published online 2024 Feb 29. doi: 10.3390/ijms25052817

PMCID:: PMC10932366

Abstract Article PDF–6.7M

Select item 107649583.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 105175674.

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression

Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du, Shang-Ze Li

J Transl Med. 2023; 21: 656. Published online 2023 Sep 22. doi: 10.1186/s12967-023-04311-3

PMCID:: PMC10517567

Abstract Article PDF–7.4M

Select item 104742925.

The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis

Soo Yeon Lee, Soo-Yeon Park, Seung-Hyun Lee, Hyunsik Kim, Jae-Hwan Kwon, Jung-Yoon Yoo, Kyunggon Kim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn, Hyo Sup Shim, Ho-Geun Yoon

Exp Mol Med. 2023 Aug; 55(8): 1795–1805. Published online 2023 Aug 1. doi: 10.1038/s12276-023-01066-1

PMCID:: PMC10474292

Abstract Article PDF–3.4M

Select item 104402666.

Stem Cell Properties of Gastric Cancer Stem-Like Cells under Stress Conditions Are Regulated via the c-Fos/UCH-L3/β-Catenin Axis

Jae Hyeong Lee, Sang-Ah Park, Il-Geun Park, Bo Kyung Yoon, Jung-Shin Lee, Ji Min Lee

Mol Cells. 2023 Aug 31; 46(8): 476–485. Published online 2023 Jul 18. doi: 10.14348/molcells.2023.0011

PMCID:: PMC10440266

Abstract Article PDF–1.8M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102021838.

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan

Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091

PMCID:: PMC10202183

Abstract Article PDF–18M

Select item 101543859.

The deubiquitinating enzyme UCHL3 promotes anaplastic thyroid cancer progression and metastasis through Hippo signaling pathway

Jianing Tang, Qian Yang, Chao Mao, Desheng Xiao, Shuang Liu, Liang Xiao, Ledu Zhou, Gaosong Wu, Yongguang Tao

Cell Death Differ. 2023 May; 30(5): 1247–1259. Published online 2023 Feb 22. doi: 10.1038/s41418-023-01134-z

PMCID:: PMC10154385

Abstract Article PDF–6.3M

Select item 1003604010.

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin

Qiancheng Ma, Qiliang Lu, Xiangxiang Lei, Jie Zhao, Wen Sun, Jun Wang, Qing Zhu, Dongsheng Huang

Front Oncol. 2023; 13: 1088475. Published online 2023 Mar 9. doi: 10.3389/fonc.2023.1088475

PMCID:: PMC10036040

Abstract Article PDF–5.6M

Select item 950105311.

Structural Insights into the Phosphorylation-Enhanced Deubiquitinating Activity of UCHL3 and Ubiquitin Chain Cleavage Preference Analysis

Yujing Ren, Beiming Yu, Lihui Zhou, Feng Wang, Yanfeng Wang

Int J Mol Sci. 2022 Sep; 23(18): 10789. Published online 2022 Sep 15. doi: 10.3390/ijms231810789

PMCID:: PMC9501053

Abstract Article PDF–2.1M

Select item 948160212.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner

Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1

PMCID:: PMC9481602

Abstract Article PDF–3.7M

Select item 939206313.

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai, Xiaoyan Huang, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson K. C. Chiu, Weiye Zhong, Gang Li

Nat Commun. 2022; 13: 4906. Published online 2022 Aug 20. doi: 10.1038/s41467-022-32689-z

PMCID:: PMC9392063

Abstract Article PDF–2.0M

Select item 905853914.

K27‐linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

Robert F Shearer, Dimitris Typas, Fabian Coscia, Sofie Schovsbo, Thomas Kruse, Andreas Mund, Niels Mailand

EMBO J. 2022 May; 41(9): e110145. Published online 2022 Mar 29. doi: 10.15252/embj.2021110145

PMCID:: PMC9058539

Abstract Article PDF–2.9M

Select item 902051715.

Structural and functional consequences of NEDD8 phosphorylation

Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner

Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9

PMCID:: PMC9020517

Abstract Article PDF–2.8M

Select item 889702216.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 877357317.

Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3

Chad S. Hewitt, Chittaranjan Das, Daniel P. Flaherty

Biomolecules. 2022 Jan; 12(1): 62. Published online 2022 Jan 1. doi: 10.3390/biom12010062

PMCID:: PMC8773573

Abstract Article PDF–1.7M

Select item 856647318.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6