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Select item 99362291.

RASGRP2 is a potential immune-related biomarker and regulates mitochondrial-dependent apoptosis in lung adenocarcinoma

Yongting Liu, Yanhong Ouyang, Ziyang Feng, Zhaohui Jiang, Jiayao Ma, Xin Zhou, Changjing Cai, Ying Han, Shan Zeng, Shanshan Liu, Hong Shen

Front Immunol. 2023; 14: 1100231. Published online 2023 Feb 3. doi: 10.3389/fimmu.2023.1100231

PMCID:: PMC9936229

Abstract Article PDF–8.6M

Select item 86182132.

CalDAG-GEFI Deficiency in a Family with Symptomatic Heterozygous and Homozygous Carriers of a Likely Pathogenic Variant in RASGRP2

Sara Morais, Mónica Pereira, Catarina Lau, Ana Gonçalves, Catarina Monteiro, Marta Gonçalves, Jorge Oliveira, Lurdes Moreira, Eugénia Cruz, Rosário Santos, Margarida Lima

Int J Mol Sci. 2021 Nov; 22(22): 12423. Published online 2021 Nov 17. doi: 10.3390/ijms222212423

PMCID:: PMC8618213

Abstract Article PDF–400K

Select item 85378983.

The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review

Jun-ichi Takino, Shouhei Miyazaki, Kentaro Nagamine, Takamitsu Hori

Int J Mol Sci. 2021 Oct; 22(20): 11129. Published online 2021 Oct 15. doi: 10.3390/ijms222011129

PMCID:: PMC8537898

Abstract Article PDF–1.3M

Select item 82203914.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78593936.

RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells

Jun-ichi Takino, Takuma Sato, Takumi Kanetaka, Kasumi Okihara, Kentaro Nagamine, Masayoshi Takeuchi, Takamitsu Hori

Sci Rep. 2021; 11: 2959. Published online 2021 Feb 3. doi: 10.1038/s41598-021-82619-0

PMCID:: PMC7859393

Abstract Article PDF–1.7M

Select item 73220677.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 70376028.

RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology

Matthias Canault, Marie-Christine Alessi

Int J Mol Sci. 2020 Feb; 21(3): 1075. Published online 2020 Feb 6. doi: 10.3390/ijms21031075

PMCID:: PMC7037602

Abstract Article PDF–1.4M

Select item 67868739.

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan

mBio. 2019 Sep-Oct; 10(5): e02169-19. Published online 2019 Oct 8. doi: 10.1128/mBio.02169-19

PMCID:: PMC6786873

Abstract Article PDF–2.2M

Select item 649224210.

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)

Emilse Bermejo, Maria F Alberto, David S Paul, Aaron A Cook, Paquita Nurden, Analia Sanchez Luceros, Alan Nurden, Wolfgang Bergmeier

Platelets. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Platelets. 2018 Jan; 29(1): 84–86. Published online 2017 Jul 20. doi: 10.1080/09537104.2017.1332759

PMCID:: PMC6492242

Abstract Article PDF–395K

Select item 642409811.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz

iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026

PMCID:: PMC6424098

Abstract Article PDF–11M

Select item 603966512.

Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells

Silvia Mele, Stephen Devereux, Andrea G. Pepper, Elvira Infante, Anne J. Ridley

Blood Adv. 2018 Jul 10; 2(13): 1551–1561. Published online 2018 Jul 3. doi: 10.1182/bloodadvances.2017014506

PMCID:: PMC6039665

Abstract Article PDF–1.6M

Select item 599210413.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 578579814.

Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding

Sarah K. Westbury, Matthias Canault, Daniel Greene, Emilse Bermejo, Katharine Hanlon, Michele P. Lambert, Carolyn M. Millar, Paquita Nurden, Samya G. Obaji, Shoshana Revel-Vilk, Chris Van Geet, Kate Downes, Sofia Papadia, Salih Tuna, Christopher Watt, NIHR BioResource–Rare Diseases Consortium, Kathleen Freson, Michael A. Laffan, Willem H. Ouwehand, Marie-Christine Alessi, Ernest Turro, Andrew D. Mumford

Blood. 2017 Aug 24; 130(8): 1026–1030. Prepublished online 2017 Jun 21. doi: 10.1182/blood-2017-03-776773

PMCID:: PMC5785798

Abstract Article

Select item 500951515.

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

María Luisa Lozano, Aaron Cook, José María Bastida, David S. Paul, Gemma Iruin, Ana Rosa Cid, Rosa Adan-Pedroso, José Ramón González-Porras, Jesús María Hernández-Rivas, Sarah J. Fletcher, Ben Johnson, Neil Morgan, Francisca Ferrer-Marin, Vicente Vicente, John Sondek, Steve P. Watson, Wolfgang Bergmeier, José Rivera

Blood. 2016 Sep 1; 128(9): 1282–1289. Prepublished online 2016 May 27. doi: 10.1182/blood-2015-11-683102

PMCID:: PMC5009515

Abstract Article

Select item 490026316.

Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

Agnes Czikora, Daniel J. Lundberg, Adelle Abramovitz, Nancy E. Lewin, Noemi Kedei, Megan L. Peach, Xiaoling Zhou, Raymond C. Merritt, Jr., Elizabeth A. Craft, Derek C. Braun, Peter M. Blumberg

J Biol Chem. 2016 May 20; 291(21): 11133–11147. Published online 2016 Mar 28. doi: 10.1074/jbc.M116.725333

PMCID:: PMC4900263

Abstract Article PDF–3.0M

Select item 487287017.

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

Jinqi Ren, Aaron A. Cook, Wolfgang Bergmeier, John Sondek

Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 May 20.

Published in final edited form as: Biochem Biophys Res Commun. 2016 May 20; 474(1): 193–198. Published online 2016 Apr 21. doi: 10.1016/j.bbrc.2016.04.100

PMCID:: PMC4872870

Abstract Article PDF–1.1M

Select item 407659118.

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

Matthias Canault, Dorsaf Ghalloussi, Charlotte Grosdidier, Marie Guinier, Claire Perret, Nadjim Chelghoum, Marine Germain, Hana Raslova, Franck Peiretti, Pierre E. Morange, Noemie Saut, Xavier Pillois, Alan T. Nurden, François Cambien, Anne Pierres, Timo K. van den Berg, Taco W. Kuijpers, Marie-Christine Alessi, David-Alexandre Tregouet

J Exp Med. 2014 Jun 30; 211(7): 1349–1362. doi: 10.1084/jem.20130477

PMCID:: PMC4076591

Abstract Article PDF–3.1M

Select item 371199119.

Ras guanyl nucleotide releasing protein 2 affects cell viability and cell–matrix adhesion in ECV304 endothelial cells

Junichi Takino, Kentaro Nagamine, Takamitsu Hori

Cell Adh Migr. 2013 May 1; 7(3): 262–266. Published online 2013 Apr 5. doi: 10.4161/cam.24082

PMCID:: PMC3711991

Abstract Article PDF–1.1M

Select item 319082620.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

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