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Select item 109452741.

E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (I_to) and corresponding channel proteins

Anatoli Y. Kabakov, Karim Roder, Peter Bronk, Nilüfer N. Turan, Saroj Dhakal, Mingwang Zhong, Yichun Lu, Zachary A. Zeltzer, Yonatan B. Najman-Licht, Alain Karma, Gideon Koren

J Biol Chem. 2024 Mar; 300(3): 105759. Published online 2024 Feb 15. doi: 10.1016/j.jbc.2024.105759

PMCID:: PMC10945274

Abstract Article PDF–1.7M

Select item 96739252.

Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria

Rishith Ravindran, Anoop Kumar G. Velikkakath, Nikhil Dev Narendradev, Aneesh Chandrasekharan, T. R. Santhoshkumar, Srinivasa M. Srinivasula

Autophagy. 2022; 18(12): 2851–2864. Published online 2022 Apr 3. doi: 10.1080/15548627.2022.2052460

PMCID:: PMC9673925

Abstract Article PDF–3.9M

Select item 91052353.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 89596314.

The Ubiquitin Ligase RNF34 Participates in the Peripheral Quality Control of CFTR (RNF34 Role in CFTR PeriQC)

Shogo Taniguchi, Yukiko Ito, Hibiki Kiritani, Asuka Maruo, Ryohei Sakai, Yuji Ono, Ryosuke Fukuda, Tsukasa Okiyoneda

Front Mol Biosci. 2022; 9: 840649. Published online 2022 Mar 9. doi: 10.3389/fmolb.2022.840649

PMCID:: PMC8959631

Abstract Article PDF–3.0M

Select item 89515565.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71139137.

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate

Christian M. Loch, James E. Strickler

Biochim Biophys Acta Mol Cell Res. 2012 Nov; 1823(11): 2069–2078. Published online 2012 May 21. doi: 10.1016/j.bbamcr.2012.05.006

PMCID:: PMC7113913

Abstract Article PDF–1.5M

Select item 63228938.

Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL)

Karim Roder, Anatoli Kabakov, Karni S. Moshal, Kevin R. Murphy, An Xie, Samuel Dudley, Nilüfer N. Turan, Yichun Lu, Calum A. MacRae, Gideon Koren

J Biol Chem. 2019 Jan 4; 294(1): 351–360. Published online 2018 Nov 6. doi: 10.1074/jbc.RA118.003852

PMCID:: PMC6322893

Abstract Article PDF–1.6M

Select item 56785819.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 557869110.

Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA

Xi Cheng, Harshal Waghulde, Blair Mell, Eric E. Morgan, Shondra M. Pruett-Miller, Bina Joe

PLoS Genet. 2017 Aug; 13(8): e1006961. Published online 2017 Aug 21. doi: 10.1371/journal.pgen.1006961

PMCID:: PMC5578691

Abstract Article PDF–13M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 464794112.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721113.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 383713714.

Different Raf Protein Kinases Mediate Different Signaling Pathways to Stimulate E3 Ligase RFFL Gene Expression in Cell Migration Regulation

Xiaoqing Gan, Chen Wang, Maulik Patel, Barry Kreutz, Maggie Zhou, Tohru Kozasa, Dianqing Wu

J Biol Chem. 2013 Nov 22; 288(47): 33978–33984. Published online 2013 Oct 10. doi: 10.1074/jbc.M113.477406

PMCID:: PMC3837137

Abstract Article PDF–1.1M

Select item 338927115.

PRR5L degradation promotes MTORC2-mediated PKCd phosphorylation and cell migration downstream of Ga12

Xiaoqing Gan, Jiyong Wang, Chen Wang, Eeva Sommer, Tohru Kozasa, Srinivasa Srinivasula, Dario Alessi, Stefan Offermanns, Melvin I. Simon, Dianqing Wu

Nat Cell Biol. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Nat Cell Biol. 2012 Jul; 14(7): 686–696. Published online 2012 May 20. doi: 10.1038/ncb2507

PMCID:: PMC3389271

Abstract Article PDF–2.6M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 295349517.

Expression of Conjoined Genes: Another Mechanism for Gene Regulation in Eukaryotes

Tulika Prakash, Vineet K. Sharma, Naoki Adati, Ritsuko Ozawa, Naveen Kumar, Yuichiro Nishida, Takayoshi Fujikake, Tadayuki Takeda, Todd D. Taylor

PLoS One. 2010; 5(10): e13284. Published online 2010 Oct 12. doi: 10.1371/journal.pone.0013284

PMCID:: PMC2953495

Abstract Article PDF–1.0M

Select item 292822418.

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity

HD Hosgood, III, L Zhang, M Shen, SI Berndt, R Vermeulen, G Li, S Yin, M Yeager, J Yuenger, N Rothman, S Chanock, M Smith, Q Lan

Occup Environ Med. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Occup Environ Med. 2009 Dec; 66(12): 848–853. Published online 2009 Sep 22. doi: 10.1136/oem.2008.044024

PMCID:: PMC2928224

Abstract Article PDF–321K

Select item 273665219.

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

Sjoerd J L van Wijk, Sjoerd J de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M J J Bonvin, H Th Marc Timmers

Mol Syst Biol. 2009; 5: 295. Published online 2009 Aug 18. doi: 10.1038/msb.2009.55

Correction in:: Mol Syst Biol. 2009; 5: 317.

PMCID:: PMC2736652

Abstract Article PDF–5.6M

Select item 270144920.

Common variants at ten loci influence myocardial repolarization: the QTGEN consortium

Christopher Newton-Cheh, Mark Eijgelsheim, Kenneth Rice, Paul I. W. de Bakker, Xiaoyan Yin, Karol Estrada, Joshua Bis, Kristin Marciante, Fernando Rivadeneira, Peter A. Noseworthy, Nona Sotoodehnia, Nicholas L. Smith, Jerome I. Rotter, Jan A. Kors, Jacqueline C.M. Witteman, Albert Hofman, Susan R. Heckbert, Christopher J. O’Donnell, Andre G. Uitterlinden, Bruce M. Psaty, Thomas Lumley, Martin G. Larson, Bruno H.Ch. Stricker

Nat Genet. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Nat Genet. 2009 Apr; 41(4): 399–406. Published online 2009 Mar 22. doi: 10.1038/ng.364

PMCID:: PMC2701449

Abstract Article PDF–804K

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