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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107118072.

BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation

Wei-Wei Li, Xu-Xu Fan, Zhi-Sheng Xu, Zi-Xiang Zhu, Zhao-Yu Zhu, Xue-Jing Cao, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng

J Cell Biol. 2024 Feb 5; 223(2): e202302081. Published online 2023 Dec 11. doi: 10.1083/jcb.202302081

PMCID:: PMC10711807

Abstract Article PDF–7.0M

Select item 106219923.

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li, Xu-Xu Fan, Zi-Xiang Zhu, Xue-Jing Cao, Zhao-Yu Zhu, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng

PLoS Pathog. 2023 Oct; 19(10): e1011742. Published online 2023 Oct 23. doi: 10.1371/journal.ppat.1011742

PMCID:: PMC10621992

Abstract Article PDF–3.9M

Select item 65252034.

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa

Nat Commun. 2019; 10: 2201. Published online 2019 May 17. doi: 10.1038/s41467-019-10242-9

PMCID:: PMC6525203

Abstract Article PDF–3.1M

Select item 53812265.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 52958216.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 44584377.

Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mouse and Human Dependent on BLK Expression Levels

Ying-Yu Wu, Ina Georg, Alejandro Díaz-Barreiro, Nieves Varela, Bernard Lauwerys, Ramesh Kumar, Harini Bagavant, Mireia Castillo-Martín, Fadi El Salem, Concepción Marañón, Marta E. Alarcón-Riquelme

J Immunol. Author manuscript; available in PMC 2016 Jun 15.

Published in final edited form as: J Immunol. 2015 Jun 15; 194(12): 5692–5702. Published online 2015 May 13. doi: 10.4049/jimmunol.1402736

PMCID:: PMC4458437

Abstract Article PDF–4.4M

Select item 40960158.

Blk-Haploinsufficiency Impairs the Development, but Enhances the Functional Responses, of MZ B Cells

Elizabeth M. Samuelson, Renee M. Laird, Alexander C. Maue, Rosemary Rochford, Sandra M. Hayes

Immunol Cell Biol. Author manuscript; available in PMC 2014 Jul 14.

Published in final edited form as: Immunol Cell Biol. 2012 Jul; 90(6): 620–629. Published online 2011 Sep 6. doi: 10.1038/icb.2011.76

PMCID:: PMC4096015

Abstract Article PDF–4.4M

Select item 39649559.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 395687410.

Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

Elizabeth M. Samuelson, Renee M. Laird, Amber M. Papillion, Arthur H. Tatum, Michael F. Princiotta, Sandra M. Hayes

PLoS One. 2014; 9(3): e92054. Published online 2014 Mar 17. doi: 10.1371/journal.pone.0092054

PMCID:: PMC3956874

Abstract Article PDF–4.1M

Select item 362587011.

FAK–Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique

Guangping Tai, Peter Hohenstein, Jamie A. Davies

Biol Open. 2013 Apr 15; 2(4): 416–423. Published online 2013 Feb 26. doi: 10.1242/bio.20133780

PMCID:: PMC3625870

Abstract Article PDF–1.0M

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 340883913.

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells

Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia Miron, Xueqing Zhang, Michael Brehm, Dongguang Li, Michael R. Green, Shaoguang Li

Nat Genet. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Nat Genet. 2012 Aug; 44(8): 861–871. Published online 2012 Jul 15. doi: 10.1038/ng.2350

PMCID:: PMC3408839

Abstract Article PDF–2.7M

Select item 339065114.

Tyrosine Kinase Btk Is Required for NK Cell Activation

Yan Bao, Jian Zheng, Chaofeng Han, Jing Jin, Huanxing Han, Yinping Liu, Yu-Lung Lau, Wenwei Tu, Xuetao Cao

J Biol Chem. 2012 Jul 6; 287(28): 23769–23778. Published online 2012 May 15. doi: 10.1074/jbc.M112.372425

Correction in:: J Biol Chem. 2020 Mar 6; 295(10): 3389.

PMCID:: PMC3390651

Abstract Article PDF–3.9M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 298967616.

Unexpected Role for the B cell-specific Src Family Kinase Blk in the Development of IL-17-Producing γδ T Cells

Renee M. Laird, Karen Laky, Sandra M. Hayes

J Immunol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: J Immunol. 2010 Dec 1; 185(11): 6518–6527. Published online 2010 Oct 25. doi: 10.4049/jimmunol.1002766

PMCID:: PMC2989676

Abstract Article PDF–1.3M

Select item 252555517.

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105

Vivien W.F. Chan, Ingrid Mecklenbräuker, I-hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky

J Exp Med. 1998 Jul 1; 188(1): 93–101. doi: 10.1084/jem.188.1.93

PMCID:: PMC2525555

Abstract Article PDF–232K

Select item 251965618.

Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn

Mark Rovedo, Richard Longnecker

J Virol. 2008 Sep; 82(17): 8520–8528. Published online 2008 Jun 25. doi: 10.1128/JVI.00843-08

PMCID:: PMC2519656

Abstract Article PDF–434K

Select item 219415519.

Mimicry of Pre–B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk

Theresa Tretter, Ashley E. Ross, Dominic I. Dordai, Stephen Desiderio

J Exp Med. 2003 Dec 15; 198(12): 1863–1873. doi: 10.1084/jem.20030729

PMCID:: PMC2194155

Abstract Article PDF–506K

Select item 141356820.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

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