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Items: 1 to 20 of 36

1.
Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
Eva Moreno, Augustine B. Matondo, Laura Bongiovanni, Chris H. A. van de Lest, Martijn R. Molenaar, Mathilda J. M. Toussaint, Saskia C. van Essen, Martin Houweling, J. Bernd Helms, Bart Westendorp, Alain de Bruin
Liver Int. 2022 Nov; 42(11): 2442–2452. Published online 2022 Sep 2. doi: 10.1111/liv.15384
PMCID:
PMC9826152
AbstractArticlePDF–3.8M
2.
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen
Nat Commun. 2022; 13: 6069. Published online 2022 Oct 14. doi: 10.1038/s41467-022-33733-8
PMCID:
PMC9568563
AbstractArticlePDF–1.8M
3.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
4.
E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice
Eva Moreno, Mathilda J.M. Toussaint, Saskia C. van Essen, Laura Bongiovanni, Elsbeth A. van Liere, Mirjam H. Koster, Ruixue Yuan, Jan M. van Deursen, Bart Westendorp, Alain de Bruin
Hepatology. 2021 Jan; 73(1): 303–317. Published online 2021 Feb 6. doi: 10.1002/hep.31259
PMCID:
PMC7898887
AbstractArticlePDF–1.6M
5.
Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation
Maria C. Cuitiño, Thierry Pécot, Daokun Sun, Raleigh Kladney, Takayuki Okano-Uchida, Neelam Shinde, Resham Saeed, Antonio J. Perez-Castro, Amy Webb, Tom Liu, Soo In Bae, Linda Clijsters, Nicholas Selner, Vincenzo Coppola, Cynthia Timmers, Michael C. Ostrowski, Michele Pagano, Gustavo Leone
Cell Rep. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: Cell Rep. 2019 Jun 18; 27(12): 3547–3560.e5. Published online 2019 May 23. doi: 10.1016/j.celrep.2019.05.004
PMCID:
PMC6673649
AbstractArticlePDF–3.3M
6.
Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury
Patrick D. Wilkinson, Frances Alencastro, Evan R. Delgado, Madeleine P. Leek, Matthew P. Weirich, P. Anthony Otero, Nairita Roy, Whitney K. Brown, Michael Oertel, Andrew W. Duncan
Am J Pathol. 2019 Jun; 189(6): 1241–1255. doi: 10.1016/j.ajpath.2019.02.008
PMCID:
PMC6547059
AbstractArticlePDF–2.7M
7.
The polyploid state plays a tumor suppressive role in the liver
Shuyuan Zhang, Kejin Zhou, Xin Luo, Lin Li, Ho-Chou Tu, Alfica Sehgal, Liem Nguyen, Yu Zhang, Purva Gopal, Branden Tarlow, Daniel Siegwart, Hao Zhu
Dev Cell. Author manuscript; available in PMC 2019 Feb 26.
Published in final edited form as: Dev Cell. 2018 Feb 26; 44(4): 447–459.e5. Published online 2018 Feb 8. doi: 10.1016/j.devcel.2018.01.010
Correction in:
Dev Cell. 2018 Nov 5; 47(3): 390.
PMCID:
PMC5828993
AbstractArticlePDF–3.2M
8.
Atypical E2Fs inhibit tumor angiogenesis
B G M W Weijts, B Westendorp, B T Hien, L M Martínez-López, M Zijp, I Thurlings, R E Thomas, S Schulte-Merker, W J Bakker, A de Bruin
Oncogene. 2018 Jan 11; 37(2): 271–276. Published online 2017 Sep 18. doi: 10.1038/onc.2017.336
PMCID:
PMC5770600
AbstractArticlePDF–1.4M
9.
Atypical E2f functions are critical for pancreas polyploidization
Ramadhan B. Matondo, Eva Moreno, Mathilda J. M. Toussaint, Peter C. J. Tooten, Saskia C. van Essen, Elsbeth A. van Liere, Sameh A. Youssef, Laura Bongiovanni, Alain de Bruin
PLoS One. 2018; 13(1): e0190899. Published online 2018 Jan 12. doi: 10.1371/journal.pone.0190899
PMCID:
PMC5766144
AbstractArticlePDF–3.5M
10.
Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
I Thurlings, L M Martínez-López, B Westendorp, M Zijp, R Kuiper, P Tooten, L N Kent, G Leone, H J Vos, B Burgering, A de Bruin
Oncogene. 2017 Feb 9; 36(6): 829–839. Published online 2016 Jul 25. doi: 10.1038/onc.2016.251
PMCID:
PMC5311251
AbstractArticlePDF–1.5M
11.
E2f8 mediates tumor suppression in postnatal liver development
Lindsey N. Kent, Jessica B. Rakijas, Shusil K. Pandit, Bart Westendorp, Hui-Zi Chen, Justin T. Huntington, Xing Tang, Sooin Bae, Arunima Srivastava, Shantibhusan Senapati, Christopher Koivisto, Chelsea K. Martin, Maria C. Cuitino, Miguel Perez, Julian M. Clouse, Veda Chokshi, Neelam Shinde, Raleigh Kladney, Daokun Sun, Antonio Perez-Castro, Ramadhan B. Matondo, Sathidpak Nantasanti, Michal Mokry, Kun Huang, Raghu Machiraju, Soledad Fernandez, Thomas J. Rosol, Vincenzo Coppola, Kamal S. Pohar, James M. Pipas, Carl R. Schmidt, Alain de Bruin, Gustavo Leone
J Clin Invest. 2016 Aug 1; 126(8): 2955–2969. Published online 2016 Jul 25. doi: 10.1172/JCI85506
PMCID:
PMC4966321
AbstractArticlePDF–6.8M
12.
The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
John P. Ray, Matthew M. Staron, Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, Joe Craft
Immunity. Author manuscript; available in PMC 2016 Oct 20.
Published in final edited form as: Immunity. 2015 Oct 20; 43(4): 690–702. Published online 2015 Sep 22. doi: 10.1016/j.immuni.2015.08.017
PMCID:
PMC4618086
AbstractArticlePDF–2.2M
13.
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization
Qian-Rong Qi, Xu-Yu Zhao, Ru-Juan Zuo, Tong-Song Wang, Xiao-Wei Gu, Ji-Long Liu, Zeng-Ming Yang
Cell Cycle. 2015 Jun 15; 14(12): 1842–1858. Published online 2015 Apr 18. doi: 10.1080/15384101.2015.1033593
PMCID:
PMC4614110
AbstractArticlePDF–2.4M
14.
Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation
Seda Ghazaryan, Chandler Sy, Tinghui Hu, Xiuli An, Narla Mohandas, Haiqing Fu, Mirit I. Aladjem, Victor T. Chang, Rene Opavsky, Lizhao Wu
Mol Cell Biol. 2014 Aug; 34(15): 2833–2847. doi: 10.1128/MCB.01651-13
PMCID:
PMC4135565
AbstractArticlePDF–5.6M
15.
Canonical and Atypical E2Fs Regulate the Mammalian Endocycle
Hui-Zi Chen, Madhu M. Ouseph, Jing Li, Thierry Pécot, Veda Chokshi, Lindsey Kent, Sooin Bae, Morgan Byrne, Camille Duran, Grant Comstock, Prashant Trikha, Markus Mair, Shantibhusan Senapati, Chelsea K. Martin, Sagar Gandhi, Nicholas Wilson, Bin Liu, Yi-Wen Huang, John C. Thompson, Sundaresan Raman, Shantanu Singh, Marcelo Leone, Raghu Machiraju, Kun Huang, Xiaokui Mo, Soledad Fernandez, Ilona Kalaszczynska, Debra J. Wolgemuth, Piotr Sicinski, Tim Huang, Victor Jin, Gustavo Leone
Nat Cell Biol. Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: Nat Cell Biol. 2012 Nov; 14(11): 1192–1202. Published online 2012 Oct 14. doi: 10.1038/ncb2595
PMCID:
PMC3616487
AbstractArticlePDF–3.6M
16.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
17.
Atypical E2F Repressors and Activators Coordinate Placental Development
Madhu M. Ouseph, Jing Li, Hui-Zi Chen, Thierry Pécot, Pamela Wenzel, John C. Thompson, Grant Comstock, Veda Chokshi, Morgan Byrne, Braxton Forde, Jean-Leon Chong, Kun Huang, Raghu Machiraju, Alain de Bruin, Gustavo Leone
Dev Cell. Author manuscript; available in PMC 2013 Apr 17.
Published in final edited form as: Dev Cell. 2012 Apr 17; 22(4): 849–862. doi: 10.1016/j.devcel.2012.01.013
PMCID:
PMC3483796
AbstractArticlePDF–5.0M
18.
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1
Bart G M W Weijts, Walbert J Bakker, Peter W A Cornelissen, Kuo-Hsuan Liang, Frank H Schaftenaar, Bart Westendorp, Charlotte A C M T de Wolf, Maya Paciejewska, Colinda L G J Scheele, Lindsey Kent, Gustavo Leone, Stefan Schulte-Merker, Alain de Bruin
EMBO J. 2012 Oct 3; 31(19): 3871–3884. Published online 2012 Aug 17. doi: 10.1038/emboj.2012.231
PMCID:
PMC3463843
AbstractArticlePDF–1.4M
19.
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia
Tinghui Hu, Seda Ghazaryan, Chandler Sy, Charles Wiedmeyer, Victor Chang, Lizhao Wu
Blood. 2012 May 10; 119(19): 4532–4542. Prepublished online 2012 Mar 14. doi: 10.1182/blood-2011-10-388231
PMCID:
PMC3362366
AbstractArticle
20.
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression
Bart Westendorp, Michal Mokry, Marian J.A. Groot Koerkamp, Frank C.P. Holstege, Edwin Cuppen, Alain de Bruin
Nucleic Acids Res. 2012 Apr; 40(8): 3511–3523. Published online 2011 Dec 16. doi: 10.1093/nar/gkr1203
PMCID:
PMC3333892
AbstractArticlePDF–890K

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