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Select item 113333791.

Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging

Jose A. Ortiz, Nadiah Ghazalli, Kassandra Lopez, Jeffrey Rawson, Erika M. McCown, Eunjin Oh, Jose M. Irimia, Kevin Jou, Jacob Mares, Min-Hsuan Chen, Xiwei Wu, Heather N. Zook, Janine C. Quijano, Neslihan Erdem, Anahy Lizarraga, Fouad Kandeel, Patrick T. Fueger, Debbie C. Thurmond, Hsun Teresa Ku

Diabetes. 2024 Sep; 73(9): 1447–1461. Published online 2024 Jun 21. doi: 10.2337/db23-0490

PMCID:: PMC11333379

Abstract Article PDF–209M

Select item 111343092.

Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease

Sohi Kang, Min Ji Bae, Min Kook Kang, Hyojin Kim, Yeong-Rok Kang, Wol Soon Jo, Chang Geun Lee, Bokyung Jung, Jeongmin Lee, Changjong Moon, Yeonghoon Son, Hae-June Lee, Joong Sun Kim

Mol Med Rep. 2024 Jul; 30(1): 127. Published online 2024 May 21. doi: 10.3892/mmr.2024.13251

PMCID:: PMC11134309

Abstract Article PDF–4.2M

Select item 106165063.

G6PC1 and G6PC2 Influence Glucose-6-Phosphate Flux but not 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

Emily M. Hawes, Kayla A. Boortz, James K. Oeser, Margaret L. O’Rourke, Richard M. O’Brien

J Mol Endocrinol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: J Mol Endocrinol. 2023 Nov 1; 71(4): e230070. Published online 2023 Oct 18. doi: 10.1530/JME-23-0070

PMCID:: PMC10616506

Abstract Article PDF–1005K

Select item 105882754.

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Mark P. Keller, Emily M. Hawes, Kathryn L. Schueler, Donnie S. Stapleton, Kelly A. Mitok, Shane P. Simonett, James K. Oeser, Leesa L. Sampson, Alan D. Attie, Mark A. Magnuson, Richard M. O’Brien

Diabetes. 2023 Nov; 72(11): 1621–1628. Published online 2023 Aug 8. doi: 10.2337/db23-0215

PMCID:: PMC10588275

Abstract Article PDF–9.5M

Select item 89412075.

Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells

Mohsin Rahim, Arya Y. Nakhe, Deveena R. Banerjee, Emily M. Overway, Karin J. Bosma, Jonah C. Rosch, James K. Oeser, Bo Wang, Ethan S. Lippmann, David A. Jacobson, Richard M. O'Brien, Jamey D. Young

J Biol Chem. 2022 Apr; 298(4): 101729. Published online 2022 Feb 15. doi: 10.1016/j.jbc.2022.101729

PMCID:: PMC8941207

Abstract Article PDF–3.9M

Select item 88001186.

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

Emily M. Overway, Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach, Hassane S. Mchaourab, Lea K. Davis, Richard M. O'Brien

J Biol Chem. 2022 Feb; 298(2): 101534. Published online 2021 Dec 23. doi: 10.1016/j.jbc.2021.101534

PMCID:: PMC8800118

Abstract Article PDF–2.4M

Select item 73696017.

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien

Mol Metab. 2020 Nov; 41: 101043. Published online 2020 Jun 20. doi: 10.1016/j.molmet.2020.101043

PMCID:: PMC7369601

Abstract Article PDF–983K

Select item 73540598.

Ins1-Cre and Ins1-Cre^ER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation

Elham Mosleh, Kristy Ou, Matthew W Haemmerle, Teguru Tembo, Andrew Yuhas, Bethany A Carboneau, Shannon E Townsend, Karin J Bosma, Maureen Gannon, Richard M O’Brien, Doris A Stoffers, Maria L Golson

Endocrinology. 2020 Aug; 161(8): bqaa054. Published online 2020 Apr 8. doi: 10.1210/endocr/bqaa054

PMCID:: PMC7354059

Abstract Article

Select item 73318019.

Pancreatic Islet Beta Cell-Specific Deletion of G6pc2 Reduces Fasting Blood Glucose

Karin J. Bosma, Mohsin Rahim, Kritika Singh, Slavina B. Goleva, Martha L. Wall, Jing Xia, Kristen E. Syring, James K. Oeser, Greg Poffenberger, Owen P. McGuinness, Anna L. Means, Alvin C. Powers, Wen-hong Li, Lea K. Davis, Jamey D. Young, Richard M. O’Brien

J Mol Endocrinol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: J Mol Endocrinol. 2020 May; 64(4): 235–248. doi: 10.1530/JME-20-0031

PMCID:: PMC7331801

Abstract Article PDF–1.6M

Select item 538036810.

Effects of G6pc2 Deletion on Body Weight and Cholesterol in Mice

Kayla A. Boortz, Kristen E. Syring, Lynley D. Pound, Huan Mo, Lisa Bastarache, James K. Oeser, Owen P. McGuinness, Joshua C. Denny, Richard M. O’Brien

J Mol Endocrinol. Author manuscript; available in PMC 2018 Apr 1.

Published in final edited form as: J Mol Endocrinol. 2017 Apr; 58(3): 127–139. Published online 2017 Jan 25. doi: 10.1530/JME-16-0202

PMCID:: PMC5380368

Abstract Article PDF–1.3M

Select item 508653411.

G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance

Kayla A. Boortz, Kristen E. Syring, Rebecca A. Lee, Chunhua Dai, James K. Oeser, Owen P. McGuinness, Jen-Chywan Wang, Richard M. O'Brien

Endocrinology. 2016 Nov; 157(11): 4133–4145. Published online 2016 Sep 21. doi: 10.1210/en.2016-1678

PMCID:: PMC5086534

Abstract Article

Select item 496712312.

G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress

Kayla A. Boortz, Kristen E. Syring, Chunhua Dai, Lynley D. Pound, James K. Oeser, David A. Jacobson, Jen-Chywan Wang, Owen P. McGuinness, Alvin C. Powers, Richard M. O'Brien

Endocrinology. 2016 Aug; 157(8): 3002–3008. Published online 2016 Jun 14. doi: 10.1210/en.2016-1245

PMCID:: PMC4967123

Abstract Article

Select item 476414813.

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Leena Paul, Emily M. Walker, Yiannis Drosos, Holly A. Cyphert, Geoffrey Neale, Roland Stein, Jack South, Gerard Grosveld, Pedro L. Herrera, Beatriz Sosa-Pineda

Diabetes. 2016 Mar; 65(3): 687–698. Published online 2015 Dec 2. doi: 10.2337/db15-0713

PMCID:: PMC4764148

Abstract Article PDF–2.3M

Select item 476311114.

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development

Ahmed M. Abdellatif, Hisashi Oishi, Takahiro Itagaki, Yunshin Jung, Hossam H. Shawki, Yukari Okita, Yoshikazu Hasegawa, Hiroyuki Suzuki, Salah E. El-Morsy, Mesbah A. El-Sayed, Mahmoud B. Shoaib, Fumihiro Sugiyama, Satoru Takahashi

PLoS One. 2016; 11(2): e0150010. Published online 2016 Feb 22. doi: 10.1371/journal.pone.0150010

PMCID:: PMC4763111

Abstract Article PDF–14M

Select item 467579915.

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells

Elizabeth Conrad, Chunhua Dai, Jason Spaeth, Min Guo, Holly A. Cyphert, David Scoville, Julie Carroll, Wei-Ming Yu, Lisa V. Goodrich, David M. Harlan, Kevin L. Grove, Charles T. Roberts, Jr., Alvin C. Powers, Guoqiang Gu, Roland Stein

Am J Physiol Endocrinol Metab. 2016 Jan 1; 310(1): E91–E102. Published online 2015 Nov 10. doi: 10.1152/ajpendo.00285.2015

PMCID:: PMC4675799

Abstract Article

Select item 459900916.

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

Feihan F. Dai, Alpana Bhattacharjee, Ying Liu, Battsetseg Batchuluun, Ming Zhang, Xinye Serena Wang, Xinyi Huang, Lemieux Luu, Dan Zhu, Herbert Gaisano, Michael B. Wheeler

J Biol Chem. 2015 Oct 9; 290(41): 25045–25061. Published online 2015 Aug 13. doi: 10.1074/jbc.M115.648592

PMCID:: PMC4599009

Abstract Article PDF–2.7M

Select item 453280017.

14-3-3ζ coordinates adipogenesis of visceral fat

Gareth E. Lim, Tobias Albrecht, Micah Piske, Karnjit Sarai, Jason T. C Lee, Hayley S. Ramshaw, Sunita Sinha, Mark A. Guthridge, Amparo Acker-Palmer, Angel F. Lopez, Susanne M. Clee, Corey Nislow, James D. Johnson

Nat Commun. 2015; 6: 7671. Published online 2015 Jul 29. doi: 10.1038/ncomms8671

PMCID:: PMC4532800

Abstract Article PDF–4.4M

Select item 443955718.

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets

Martha L. Wall, Lynley D. Pound, Irina Trenary, Richard M. O’Brien, Jamey D. Young

Diabetes. 2015 Jun; 64(6): 2129–2137. Published online 2014 Dec 31. doi: 10.2337/db14-0745

PMCID:: PMC4439557

Abstract Article PDF–979K

Select item 422349119.

Progesterone Receptor Membrane Component 1 Is a Functional Part of the Glucagon-like Peptide-1 (GLP-1) Receptor Complex in Pancreatic β Cells

Ming Zhang, Mélanie Robitaille, Aaron D. Showalter, Xinyi Huang, Ying Liu, Alpana Bhattacharjee, Francis S. Willard, Junfeng Han, Sean Froese, Li Wei, Herbert Y. Gaisano, Stéphane Angers, Kyle W. Sloop, Feihan F. Dai, Michael B. Wheeler

Mol Cell Proteomics. 2014 Nov; 13(11): 3049–3062. Published online 2014 Jul 20. doi: 10.1074/mcp.M114.040196

PMCID:: PMC4223491

Abstract Article PDF–3.1M

Select item 399203220.

IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse

Y F Fuchs, K Adler, A Lindner, A Karasinsky, C Wilhelm, M Weigelt, H Balke, K Förtsch, L F Mortler-Hildebrandt, D M Harlan, K Pechhold, A-G Ziegler, E Bonifacio

Clin Exp Immunol. 2014 May; 176(2): 199–206. Published online 2014 Apr 9. doi: 10.1111/cei.12263