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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108347842.

Kidney derived apolipoprotein M and its role in acute kidney injury

Line S. Bisgaard, Pernille M. Christensen, Jeongah Oh, Federico Torta, Ernst-Martin Füchtbauer, Lars Bo Nielsen, Christina Christoffersen

Front Pharmacol. 2024; 15: 1328259. Published online 2024 Jan 19. doi: 10.3389/fphar.2024.1328259

PMCID:: PMC10834784

Abstract Article PDF–1.8M

Select item 95787133.

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E Wheelock, Sasha A Singh, Masanori Aikawa, Lois E Smith, Richard L Proia, Timothy Hla

eLife. 2022; 11: e78861. Published online 2022 Oct 5. doi: 10.7554/eLife.78861

PMCID:: PMC9578713

Abstract Article PDF–11M

Select item 89706734.

Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway

María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X. Lee, Michael J. Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R. Cook, Galina A. Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus Rasmus, Stefania Camastra, Terry G. Unterman, Ele Ferrannini, Barry E. Hurwitz, Rebecca A. Haeusler

J Clin Invest. 2022 Apr 1; 132(7): e146219. Published online 2022 Apr 1. doi: 10.1172/JCI146219

PMCID:: PMC8970673

Abstract Article PDF–4.0M

Select item 84834585.

Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine‐1‐Phosphate

Ilaria Del Gaudio, Luisa Rubinelli, Linda Sasset, Christian Wadsack, Timothy Hla, Annarita Di Lorenzo

J Am Heart Assoc. 2021 Jul 20; 10(14): e021261. Published online 2021 Jul 9. doi: 10.1161/JAHA.121.021261

PMCID:: PMC8483458

Abstract Article PDF–1.4M

Select item 84582496.

Apolipoprotein M and sphingosine-1-phosphate receptor 1 promote the transendothelial transport of HDL

Srividya Velagapudi, Lucia Rohrer, Francesco Poti, Renate Feuerborn, Damir Perisa, Dongdong Wang, Grigorios Panteloglou, Anton Potapenko, Mustafa Yalcinkaya, Andreas J. Hülsmeier, Bettina Hesse, Alexander Lukasz, Mingxia Liu, John S. Parks, Christina Christoffersen, Markus Stoffel, Manuela Simoni, Jerzy-Roch Nofer, Arnold von Eckardstein

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Oct; 41(10): e468–e479. Published online 2021 Aug 19. doi: 10.1161/ATVBAHA.121.316725

PMCID:: PMC8458249

Abstract Article PDF–2.1M

Select item 81678647.

Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages

Shuang Yao, Fan Zheng, Yang Yu, Yuxia Zhan, Ning Xu, Guanghua Luo, Lu Zheng

FEBS Open Bio. 2021 Jun; 11(6): 1607–1620. Published online 2021 May 2. doi: 10.1002/2211-5463.13157

PMCID:: PMC8167864

Abstract Article PDF–2.0M

Select item 76074488.

Aging suppresses sphingosine-1-phosphate (S1P) chaperone ApoM in circulation resulting in maladaptive organ repair

Bi-Sen Ding, Dawei Yang, Steve L. Swendeman, Christina Christoffersen, Lars Bo Nielsen, Scott L. Friedman, Charles A. Powell, Timothy Hla, Zhongwei Cao

Dev Cell. Author manuscript; available in PMC 2021 Jun 22.

Published in final edited form as: Dev Cell. 2020 Jun 22; 53(6): 677–690.e4. Published online 2020 Jun 15. doi: 10.1016/j.devcel.2020.05.024

PMCID:: PMC7607448

Abstract Article PDF–1.8M

Select item 74536639.

Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide-induced acute inflammatory apoM^−/− mice

Yuanping Shi, Hongyao Liu, Hong Liu, Yang Yu, Jun Zhang, Yanfei Li, Guanghua Luo, Xiaoying Zhang, Ning Xu

Mol Med Rep. 2020 Oct; 22(4): 3117–3126. Published online 2020 Aug 11. doi: 10.3892/mmr.2020.11426

PMCID:: PMC7453663

Abstract Article PDF–1.1M

Select item 736091710.

Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway

Shuang Yao, Jun Zhang, Yuxia Zhan, Yuanping Shi, Yang Yu, Lu Zheng, Ning Xu, Guanghua Luo

Endocr Metab Immune Disord Drug Targets. 2020 Jun; 20(5): 771–780. Published online 2020 Jun. doi: 10.2174/1871530319666191023125820

PMCID:: PMC7360917

Abstract Article PDF–3.9M

Select item 687729211.

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

Mette Mathiesen Janiurek, Rana Soylu-Kucharz, Christina Christoffersen, Krzysztof Kucharz, Martin Lauritzen

eLife. 2019; 8: e49405. Published online 2019 Nov 25. doi: 10.7554/eLife.49405

PMCID:: PMC6877292

Abstract Article PDF–5.6M

Select item 682449812.

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

Hideru Obinata, Andrew Kuo, Yukata Wada, Steven Swendeman, Catherine H. Liu, Victoria A. Blaho, Rieko Nagumo, Kenichi Satoh, Takashi Izumi, Timothy Hla

J Lipid Res. 2019 Nov; 60(11): 1912–1921. Published online 2019 Aug 29. doi: 10.1194/jlr.RA119000277

PMCID:: PMC6824498

Abstract Article PDF–1.2M

Select item 675516613.

Niacin regulates apolipoprotein M expression via liver X receptor-α

Liu Yang, Tie Li, Shuiping Zhao, Saidan Zhang

Mol Med Rep. 2019 Oct; 20(4): 3285–3291. Published online 2019 Aug 6. doi: 10.3892/mmr.2019.10557

PMCID:: PMC6755166

Abstract Article PDF–522K

Select item 638171314.

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”

Georgia Charkoftaki, Yewei Wang, Monica McAndrews, Elspeth A. Bruford, David C. Thompson, Vasilis Vasiliou, Daniel W. Nebert

Hum Genomics. 2019; 13: 11. Published online 2019 Feb 19. doi: 10.1186/s40246-019-0191-9

PMCID:: PMC6381713

Abstract Article PDF–1.0M

Select item 610934215.

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes

Yue-Hua Feng, Lu Zheng, Jiang Wei, Miao-Mei Yu, Jun Zhang, Guang-Hua Luo, Ning Xu

Lipids Health Dis. 2018; 17: 200. Published online 2018 Aug 25. doi: 10.1186/s12944-018-0849-7

PMCID:: PMC6109342

Abstract Article PDF–994K

Select item 579606116.

Apolipoprotein M Inhibits Angiogenic and Inflammatory Response by Sphingosine 1-Phosphate on Retinal Pigment Epithelium Cells

Ryo Terao, Megumi Honjo, Makoto Aihara

Int J Mol Sci. 2018 Jan; 19(1): 112. Published online 2017 Dec 31. doi: 10.3390/ijms19010112

PMCID:: PMC5796061

Abstract Article PDF–3.0M

Select item 568008917.

An engineered S1P chaperone attenuates hypertension and ischemic injury

Steven L. Swendeman, Yuquan Xiong, Anna Cantalupo, Hui Yuan, Nathalie Burg, Yu Hisano, Andreane Cartier, Catherine H. Liu, Eric Engelbrecht, Victoria Blaho, Yi Zhang, Keisuke Yanagida, Sylvain Galvani, Hideru Obinata, Jane E. Salmon, Teresa Sanchez, Annarita Di Lorenzo, Timothy Hla

Sci Signal. Author manuscript; available in PMC 2017 Nov 10.

Published in final edited form as: Sci Signal. 2017 Aug 15; 10(492): eaal2722. Published online 2017 Aug 15. doi: 10.1126/scisignal.aal2722

PMCID:: PMC5680089

Abstract Article PDF–2.1M

Select item 487179818.

Impaired endothelial barrier function in apolipoprotein M–deficient mice is dependent on sphingosine-1-phosphate receptor 1

Pernille M. Christensen, Catherine H. Liu, Steven L. Swendeman, Hideru Obinata, Klaus Qvortrup, Lars B. Nielsen, Timothy Hla, Annarita Di Lorenzo, Christina Christoffersen

FASEB J. 2016 Jun; 30(6): 2351–2359. Published online 2016 Mar 8. doi: 10.1096/fj.201500064

PMCID:: PMC4871798

Abstract Article

Select item 476881319.

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P₁ to limit vascular inflammation

Sylvain Galvani, Marie Sanson, Victoria A. Blaho, Steven L. Swendeman, Hideru Obinata, Heather Conger, Björn Dahlbäck, Mari Kono, Richard L. Proia, Jonathan D. Smith, Timothy Hla

Sci Signal. Author manuscript; available in PMC 2016 Feb 26.

Published in final edited form as: Sci Signal. 2015 Aug 11; 8(389): ra79. Published online 2015 Aug 11. doi: 10.1126/scisignal.aaa2581

Correction in:: volume 8 on page er8

PMCID:: PMC4768813

Abstract Article PDF–3.2M

Select item 475204420.

Sphingosine-1-phosphate reduces ischaemia–reperfusion injury by phosphorylating the gap junction protein Connexin43

Sandrine Morel, Christina Christoffersen, Lene N. Axelsen, Fabrizio Montecucco, Viviane Rochemont, Miguel A. Frias, Francois Mach, Richard W. James, Christian C. Naus, Marc Chanson, Paul D. Lampe, Morten S. Nielsen, Lars B. Nielsen, Brenda R. Kwak

Cardiovasc Res. 2016 Mar 1; 109(3): 385–396. Published online 2016 Jan 13. doi: 10.1093/cvr/cvw004

PMCID:: PMC4752044

Abstract Article PDF–831K

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