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Items: 1 to 20 of 86

1.
In vivo validation of late‐onset Alzheimer's disease genetic risk factors
Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter
Alzheimers Dement. 2024 Jul; 20(7): 4970–4984. Published online 2024 Apr 30. doi: 10.1002/alz.13840
PMCID:
PMC11247676
AbstractArticlePDF–3.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng
Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2
PMCID:
PMC10864363
AbstractArticlePDF–9.9M
4.
Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development
Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang
iScience. 2024 Jan 19; 27(1): 108722. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108722
PMCID:
PMC10788269
AbstractArticlePDF–11M
5.
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Alzheimers Dement. 2022 Oct; 18(10): 1765–1778. Published online 2022 Feb 9. doi: 10.1002/alz.12577
PMCID:
PMC9360195
AbstractArticlePDF–4.7M
6.
Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice
Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia Ingraham, Bridget Perkins, Christopher Lloyd, Deborah Baker, Peter B. Lin, Disha M. Soni, Andy P. Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Jill A. Meyer, Johnathan S. Peters, Lucas L. Figueiredo, Michael Sasner, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory W. Carter, Bruce T. Lamb, Gareth R. Howell
Front Aging Neurosci. 2022; 14: 886575. Published online 2022 Jun 24. doi: 10.3389/fnagi.2022.886575
PMCID:
PMC9263289
AbstractArticlePDF–6.8M
7.
PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel, Kwangsik Nho
Genome Med. 2022; 14: 17. Published online 2022 Feb 18. doi: 10.1186/s13073-022-01022-0
PMCID:
PMC8857783
AbstractArticlePDF–3.0M
8.
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522
Emily Maguire, Georgina E Menzies, Thomas Phillips, Michael Sasner, Harriet M Williams, Magdalena A Czubala, Neil Evans, Emma L Cope, Rebecca Sims, Gareth R Howell, Emyr Lloyd‐Evans, Julie Williams, Nicholas D Allen, Philip R Taylor
EMBO J. 2021 Sep 1; 40(17): e105603. Published online 2021 Jul 13. doi: 10.15252/embj.2020105603
PMCID:
PMC8408593
AbstractArticlePDF–3.1M
9.
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin
Christopher Hoover, Yuji Kondo, Bojing Shao, Michael J. McDaniel, Robert Lee, Samuel McGee, Sidney Whiteheart, Wolfgang Bergmeier, Rodger P. McEver, Lijun Xia
Blood. 2021 May 20; 137(20): 2756–2769. Prepublished online 2021 Feb 22. doi: 10.1182/blood.2020010310
PMCID:
PMC8138551
AbstractArticle
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation
Shuchi Gupta, Christoph Konradt, Adam Corken, Jerry Ware, Bernhard Nieswandt, Jorge Di Paola, Mei Yu, Demin Wang, Marvin T. Nieman, Sidney W. Whiteheart, Lawrence F. Brass
Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24316–24325. Published online 2020 Sep 14. doi: 10.1073/pnas.2007642117
PMCID:
PMC7533880
AbstractArticlePDF–2.4M
12.
The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass
Mol Neurodegener. 2020; 15: 52. Published online 2020 Sep 11. doi: 10.1186/s13024-020-00402-7
PMCID:
PMC7488484
AbstractArticlePDF–4.6M
13.
Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome
Sahil Mahajan, Corinne E. Decker, Zhengfeng Yang, Deborah Veis, Elizabeth D. Mellins, Roberta Faccio
J Autoimmun. Author manuscript; available in PMC 2020 Apr 2.
Published in final edited form as: J Autoimmun. 2019 Jun; 100: 62–74. Published online 2019 Mar 15. doi: 10.1016/j.jaut.2019.02.005
PMCID:
PMC7117784
AbstractArticlePDF–2.5M
14.
Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels
László Bálint, Zsombor Ocskay, Bálint András Deák, Petra Aradi, Zoltán Jakus
Front Immunol. 2019; 10: 3043. Published online 2020 Jan 14. doi: 10.3389/fimmu.2019.03043
PMCID:
PMC6970982
AbstractArticlePDF–18M
15.
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
Alzheimers Res Ther. 2019; 11: 16. Published online 2019 Feb 2. doi: 10.1186/s13195-019-0469-0
PMCID:
PMC6359863
AbstractArticlePDF–2.1M
16.
ATG5 is required for B cell polarization and presentation of particulate antigens
Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros
Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327
PMCID:
PMC6333460
AbstractArticlePDF–2.7M
17.
LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow
Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher
J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214
PMCID:
PMC6262777
AbstractArticle
18.
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development
Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang
Nat Commun. 2017; 8: 1457. Published online 2017 Nov 13. doi: 10.1038/s41467-017-01388-5
PMCID:
PMC5684131
AbstractArticlePDF–2.1M
19.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
20.
TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
Kevin Reppschläger, Jeanne Gosselin, Carol A. Dangelmaier, Dafydd H. Thomas, Nick Carpino, Steven E. McKenzie, Satya P. Kunapuli, Alexander Y. Tsygankov
J Biol Chem. 2016 Oct 21; 291(43): 22427–22441. Published online 2016 Sep 8. doi: 10.1074/jbc.M116.743732
Correction in:
J Biol Chem. 2017 Mar 10; 292(10): 4360.
PMCID:
PMC5077183
AbstractArticlePDF–3.2M

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