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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 97906752.

PRDM16 expression and function in mammalian cochlear development

Michael Ebeid, Kathy Barnas, Hongji Zhang, Amal Yaghmour, Gabriele Noreikaite, Bryan C. Bjork

Dev Dyn. 2022 Oct; 251(10): 1666–1683. Published online 2022 May 7. doi: 10.1002/dvdy.480

PMCID:: PMC9790675

Abstract Article PDF–17M

Select item 88451313.

Regulator of Cell Cycle Protein (RGCC/RGC-32) Protects against Pulmonary Fibrosis

Irina G. Luzina, Violeta Rus, Virginia Lockatell, Jean-Paul Courneya, Brian S. Hampton, Rita Fishelevich, Alexander V. Misharin, Nevins W. Todd, Tudor C. Badea, Horea Rus, Sergei P. Atamas

Am J Respir Cell Mol Biol. 2022 Feb; 66(2): 146–157. Published online 2021 Oct 20. doi: 10.1165/rcmb.2021-0022OC

PMCID:: PMC8845131

Abstract Article PDF–1.7M

Select item 83586714.

RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis

Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Jean-Paul Courneya, Dallas Boodhoo, Cornelia Cudrici, Dafin F. Muresanu, Violeta Rus, Tudor C. Badea, Horea Rus

Front Immunol. 2021; 12: 705308. Published online 2021 Jul 29. doi: 10.3389/fimmu.2021.705308

PMCID:: PMC8358671

Abstract Article PDF–15M

Select item 83132395.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 78683326.

RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis

Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Dallas Boodhoo, Armugam Mekala, Cornelia Cudrici, Tudor C. Badea, Dafin F. Muresanu, Violeta Rus, Horea Rus

Front Immunol. 2020; 11: 608294. Published online 2021 Jan 25. doi: 10.3389/fimmu.2020.608294

PMCID:: PMC7868332

Abstract Article PDF–8.1M

Select item 64595107.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 63584858.

An atlas of genetic influences on osteoporosis in humans and mice

John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan C. Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian Quinn, Loan Nguyen-Yamamoto, Aimee-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, Albena Pramatarova, Carolina Medina-Gomez, Katerina Trajanoska, Elena J. Ghirardello, Natalie C. Butterfield, Katharine F. Curry, Victoria D. Leitch, Penny C. Sparkes, Anne-Tounsia Adoum, Naila S. Mannan, Davide S.K. Komla-Ebri, Andrea S. Pollard, Hannah F. Dewhurst, Thomas A.D. Hassall, Michael-John G. Beltejar, 23andMe Research Team, Douglas J. Adams, Suzanne M. Vaillancourt, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia E. Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Jonathan H. Tobias, Celia L. Gregson, Nicholas C. Harvey, Elin Grundberg, David Goltzman, David J. Adams, Christopher J. Lelliott, David A. Hinds, Cheryl L. Ackert-Bicknell, Yi-Hsiang Hsu, Matthew T. Maurano, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett, David M. Evans, J. Brent Richards

Nat Genet. Author manuscript; available in PMC 2019 Jun 30.

Published in final edited form as: Nat Genet. 2019 Feb; 51(2): 258–266. Published online 2018 Dec 31. doi: 10.1038/s41588-018-0302-x

PMCID:: PMC6358485

Abstract Article PDF–1.8M

Select item 63302599.

RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis

Alexandru Tatomir, Cosmin A. Tegla, Alvaro Martin, Dallas Boodhoo, Vinh Nguyen, Adam J. Sugarman, Armugam Mekala, Freidrich Anselmo, Anamaria Talpos-Caia, Cornelia Cudrici, Tudor C. Badea, Violeta Rus, Horea Rus

Immunol Res. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Immunol Res. 2018 Aug; 66(4): 445–461. doi: 10.1007/s12026-018-9011-x

PMCID:: PMC6330259

Abstract Article PDF–4.7M

Select item 627508410.

Loss of Response Gene to Complement 32 (RGC-32) in Diabetic Mouse Retina Is Involved in Retinopathy Development

Wen-Ling Liao, Jane-Ming Lin, Shih-Ping Liu, Shih-Yin Chen, Hui-Ju Lin, Yeh-Han Wang, Yu-Jie Lei, Yu-Chuen Huang, Fuu-Jen Tsai

Int J Mol Sci. 2018 Nov; 19(11): 3629. Published online 2018 Nov 17. doi: 10.3390/ijms19113629

PMCID:: PMC6275084

Abstract Article PDF–3.9M

Select item 621465911.

Response Gene to Complement 32 Maintains Blood Pressure Homeostasis by Regulating α-Adrenergic Receptor Expression

Jun-Ming Tang, Ning Shi, Kun Dong, Scott A. Brown, Amanda E. Coleman, Matthew A. Boegehold, Shi-You Chen

Circ Res. Author manuscript; available in PMC 2019 Oct 12.

Published in final edited form as: Circ Res. 2018 Oct 12; 123(9): 1080–1090. doi: 10.1161/CIRCRESAHA.118.313266

PMCID:: PMC6214659

Abstract Article PDF–1.0M

Select item 619707012.

RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis

Violeta Rus, Vinh Nguyen, Alexandru Tatomir, Jason R. Lees, Armugam P. Mekala, Dallas Boodhoo, Cosmin A. Tegla, Irina G. Luzina, Paul A. Antony, Cornelia D. Cudrici, Tudor C. Badea, Horea G. Rus

J Immunol. Author manuscript; available in PMC 2018 Oct 22.

Published in final edited form as: J Immunol. 2017 May 15; 198(10): 3869–3877. Published online 2017 Mar 29. doi: 10.4049/jimmunol.1602158

PMCID:: PMC6197070

Abstract Article PDF–820K

Select item 610316813.

Response gene to complement 32 suppresses adipose tissue thermogenic genes through inhibiting β3-adrenergic receptor/mTORC1 signaling

Sisi Chen, Xiaohan Mei, Amelia Yin, Hang Yin, Xiao-Bing Cui, Shi-You Chen

FASEB J. 2018 Sep; 32(9): 4836–4847. Published online 2018 Mar 26. doi: 10.1096/fj.201701508R

PMCID:: PMC6103168

Abstract Article

Select item 590138914.

Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia

Jennifer L. Sones, Audrey A. Merriam, Angelina Seffens, Dex-Ann Brown-Grant, Scott D. Butler, Anna M. Zhao, Xinjing Xu, Carrie J. Shawber, Jennifer K. Grenier, Nataki C. Douglas

FASEB J. 2018 May; 32(5): 2574–2586. Published online 2018 Jan 8. doi: 10.1096/fj.201701008R

PMCID:: PMC5901389

Abstract Article

Select item 589335115.

RGC32 promotes bleomycin-induced systemic sclerosis in a murine disease model by modulating classically activated macrophage function

Chenming Sun, Shi-You Chen

J Immunol. Author manuscript; available in PMC 2019 Apr 15.

Published in final edited form as: J Immunol. 2018 Apr 15; 200(8): 2777–2785. Published online 2018 Mar 5. doi: 10.4049/jimmunol.1701542

PMCID:: PMC5893351

Abstract Article PDF–2.8M

Select item 588312516.

Renal proteomic analysis of RGC-32 knockout mice reveals the potential mechanism of RGC-32 in regulating cell cycle

Yu-Jie Hu, Qian Zhou, Zhu-Yin Li, Dan Feng, Lei Sun, Yun-Lin Shen, Wen-Yan Huang

Am J Transl Res. 2018; 10(3): 847–856. Published online 2018 Mar 15.

PMCID:: PMC5883125

Abstract Article PDF–1.0M

Select item 586454417.

RGC-32 deficiency protects endothelial cell from inflammation and attenuates atherosclerosis

Xiao-Bing Cui, Jun-Na Luan, Kun Dong, Sisi Chen, Yongyi Wang, Wendy T. Watford, Shi-You Chen

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Apr; 38(4): e36–e47. Published online 2018 Feb 15. doi: 10.1161/ATVBAHA.117.310656

PMCID:: PMC5864544

Abstract Article PDF–1.0M

Select item 529582118.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 506155519.

RGC-32 is a novel regulator of the T-lymphocyte cell cycle

Cosmin A. Tegla, Cornelia D. Cudrici, Vinh Nguyen, Jacob Danoff, Adam M. Kruszewski, Dallas Boodhoo, Armugam P. Mekala, Sonia I. Vlaicu, Ching Chen, Violeta Rus, Tudor C. Badea, Horea Rus

Exp Mol Pathol. Author manuscript; available in PMC 2016 Oct 12.

Published in final edited form as: Exp Mol Pathol. 2015 Jun; 98(3): 328–337. Published online 2015 Mar 11. doi: 10.1016/j.yexmp.2015.03.011

PMCID:: PMC5061555

Abstract Article PDF–1011K

Select item 473971920.

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression

David B. West, Eric K. Engelhard, Michael Adkisson, A. J. Nava, Julia V. Kirov, Andreanna Cipollone, Brandon Willis, Jared Rapp, Pieter J. de Jong, Kent C. Lloyd

PLoS Genet. 2016 Feb; 12(2): e1005691. Published online 2016 Feb 3. doi: 10.1371/journal.pgen.1005691

PMCID:: PMC4739719

Abstract Article PDF–1.5M

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