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Select item 107212611.

Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis

Vladimir S. Ermakov, Jeffry C. Granados, Sanjay K. Nigam

JCI Insight. 2023 Nov 8; 8(21): e172341. Published online 2023 Nov 8. doi: 10.1172/jci.insight.172341

PMCID:: PMC10721261

Abstract Article PDF–1.2M

Select item 99773162.

The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism

Jeffry C. Granados, Vladimir Ermakov, Koustav Maity, David R. Vera, Geoffrey Chang, Sanjay K. Nigam

JCI Insight. 2023 Jan 24; 8(2): e160437. Published online 2023 Jan 24. doi: 10.1172/jci.insight.160437

PMCID:: PMC9977316

Abstract Article PDF–5.9M

Select item 88475653.

Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice

Christian Litke, Anna M. Hagenston, Ann-Kristin Kenkel, Eszter Paldy, Jianning Lu, Rohini Kuner, Daniela Mauceri

Nat Commun. 2022; 13: 875. Published online 2022 Feb 15. doi: 10.1038/s41467-022-28357-x

PMCID:: PMC8847565

Abstract Article PDF–1.8M

Select item 84463384.

ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1

Wesley Wang, Dolena Ledee

Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073

PMCID:: PMC8446338

Abstract Article PDF–830K

Select item 81264795.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

Dis Model Mech. 2021 May 1; 14(5): dmm047498. Published online 2021 May 4. doi: 10.1242/dmm.047498

PMCID:: PMC8126479

Abstract Article

Select item 81024106.

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3

Jeffry C. Granados, Anne Richelle, Jahir M. Gutierrez, Patrick Zhang, Xinlian Zhang, Vibha Bhatnagar, Nathan E. Lewis, Sanjay K. Nigam

J Biol Chem. 2021 Jan-Jun; 296: 100575. Published online 2021 Mar 21. doi: 10.1016/j.jbc.2021.100575

PMCID:: PMC8102410

Abstract Article PDF–2.5M

Select item 81024047.

A key role for the transporter OAT1 in systemic lipid metabolism

Jeffry C. Granados, Anisha K. Nigam, Kevin T. Bush, Neema Jamshidi, Sanjay K. Nigam

J Biol Chem. 2021 Jan-Jun; 296: 100603. Published online 2021 Mar 27. doi: 10.1016/j.jbc.2021.100603

PMCID:: PMC8102404

Abstract Article PDF–1.6M

Select item 72052568.

Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease

Kevin T. Bush, Prabhleen Singh, Sanjay K. Nigam

JCI Insight. 2020 Apr 9; 5(7): e133817. Published online 2020 Apr 9. doi: 10.1172/jci.insight.133817

PMCID:: PMC7205256

Abstract Article PDF–1.9M

Select item 70291109.

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning

Anisha K. Nigam, Julia G. Li, Kaustubh Lall, Da Shi, Kevin T. Bush, Vibha Bhatnagar, Ruben Abagyan, Sanjay K. Nigam

J Biol Chem. 2020 Feb 14; 295(7): 1829–1842. Published online 2020 Jan 2. doi: 10.1074/jbc.RA119.010729

PMCID:: PMC7029110

Abstract Article PDF–3.1M

Select item 622262110.

Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD

Tianqiao Yong, Dan Li, Muxia Li, Danling Liang, Xue Diao, Chenling Deng, Shaodan Chen, Yizhen Xie, Diling Chen, Dan Zuo

Molecules. 2018 Oct; 23(10): 2671. Published online 2018 Oct 17. doi: 10.3390/molecules23102671

PMCID:: PMC6222621

Abstract Article PDF–4.1M

Select item 613952811.

Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin

Yiling Fu, Davorka Breljak, Akira Onishi, Falk Batz, Rohit Patel, Winnie Huang, Panai Song, Brent Freeman, Eric Mayoux, Hermann Koepsell, Naohiko Anzai, Sanjay K. Nigam, Ivan Sabolic, Volker Vallon

Am J Physiol Renal Physiol. 2018 Aug 1; 315(2): F386–F394. Published online 2018 Feb 7. doi: 10.1152/ajprenal.00503.2017

PMCID:: PMC6139528

Abstract Article

Select item 559316812.

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity

S Hu, AF Leblanc, AA Gibson, KW Hong, JY Kim, LJ Janke, L Li, A Vasilyeva, DB Finkelstein, JA Sprowl, DH Sweet, E Schlatter, G Ciarimboli, JHM Schellens, SD Baker, N Pabla, A Sparreboom

Clin Transl Sci. 2017 Sep; 10(5): 412–420. Published online 2017 Jul 8. doi: 10.1111/cts.12480

PMCID:: PMC5593168

Abstract Article PDF–1.2M

Select item 501668513.

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network

Henry C. Liu, Neema Jamshidi, Yuchen Chen, Satish A. Eraly, Sai Yee Cho, Vibha Bhatnagar, Wei Wu, Kevin T. Bush, Ruben Abagyan, Bernhard O. Palsson, Sanjay K. Nigam

J Biol Chem. 2016 Sep 9; 291(37): 19474–19486. Published online 2016 Jul 20. doi: 10.1074/jbc.M116.745216

PMCID:: PMC5016685

Abstract Article PDF–2.3M

Select item 475128614.

Generation and Characterisation of a Pax8-CreER^T2 Transgenic Line and a Slc22a6-CreER^T2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

Judit Espana-Agusti, Xiangang Zou, Kim Wong, Beiyuan Fu, Fengtang Yang, David A. Tuveson, David J. Adams, Athena Matakidou

PLoS One. 2016; 11(2): e0148055. Published online 2016 Feb 11. doi: 10.1371/journal.pone.0148055

PMCID:: PMC4751286

Abstract Article PDF–23M

Select item 469566215.

Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice

Wen-Hao Yu, Na Zhang, Jin-Feng Qi, Chen Sun, Yong-Hui Wang, Mei Lin

Biomed Res Int. 2015; 2015: 863971. Published online 2015 Dec 16. doi: 10.1155/2015/863971

PMCID:: PMC4695662

Abstract Article PDF–779K

Select item 381243516.

STRUCTURAL VARIATION GOVERNS SUBSTRATE SPECIFICITY FOR ORGANIC ANION TRANSPORTERS (OAT) HOMOLOGS: POTENTIAL REMOTE SENSING BY OAT FAMILY MEMBERS

Gregory Kaler, David M. Truong, Akash Khandelwal, Megha Nagle, Satish A. Eraly, Peter W. Swaan, Sanjay K. Nigam

J Biol Chem. Author manuscript; available in PMC 2013 Oct 30.

Published in final edited form as: J Biol Chem. 2007 Aug 17; 282(33): 10.1074/jbc.M703467200. Published online 2007 Jun 5. doi: 10.1074/jbc.M703467200

PMCID:: PMC3812435

Abstract Article PDF–2.5M

Select item 362583717.

Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys

Davorka Breljak, Hrvoje Brzica, Douglas H. Sweet, Naohiko Anzai, Ivan Sabolic

Am J Physiol Renal Physiol. 2013 Apr 15; 304(8): F1114–F1126. Published online 2013 Feb 6. doi: 10.1152/ajprenal.00201.2012

PMCID:: PMC3625837

Abstract Article

Select item 359149018.

Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue

Megha A. Nagle, Wei Wu, Satish A. Eraly, Sanjay K. Nigam

Neurosci Lett. Author manuscript; available in PMC 2014 Feb 8.

Published in final edited form as: Neurosci Lett. 2013 Feb 8; 534: 133–138. Published online 2012 Nov 27. doi: 10.1016/j.neulet.2012.11.027

PMCID:: PMC3591490

Abstract Article PDF–3.3M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 336206620.

A role for the organic anion transporter OAT3 in renal creatinine secretion in mice

Volker Vallon, Satish A. Eraly, Satish Ramachandra Rao, Maria Gerasimova, Michael Rose, Megha Nagle, Naohiko Anzai, Travis Smith, Kumar Sharma, Sanjay K. Nigam, Timo Rieg

Am J Physiol Renal Physiol. 2012 May 15; 302(10): F1293–F1299. Published online 2012 Feb 15. doi: 10.1152/ajprenal.00013.2012