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Select item 111148941.

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

Isabel F. Fernández, Luis G. Pérez-Rivas, Sandra Blanco, Adrián A. Castillo-Dominguez, José Lozano, Pedro A. Lazo

Cell Mol Life Sci. 2012 Nov; 69(22): 3881–3893. Published online 2012 Jul 4. doi: 10.1007/s00018-012-1056-8

PMCID:: PMC11114894

Abstract Article PDF–1.1M

Select item 110638212.

KSR1 Knockout Mouse Model Demonstrates MAPK Pathway’s Key Role in Cisplatin- and Noise-induced Hearing Loss

Matthew A. Ingersoll, Richard D. Lutze, Regina G. Kelmann, Daniel F. Kresock, Jordan D. Marsh, Rene V. Quevedo, Jian Zuo, Tal Teitz

J Neurosci. 2024 May 1; 44(18): e2174232024. Prepublished online 2024 Mar 28. doi: 10.1523/JNEUROSCI.2174-23.2024

PMCID:: PMC11063821

Abstract Article PDF–4.3M

Select item 80792743.

Calmodulin influences MAPK signaling by binding KSR1

Swetha Parvathaneni, Zhigang Li, David B. Sacks

J Biol Chem. 2021 Jan-Jun; 296: 100577. Published online 2021 Mar 23. doi: 10.1016/j.jbc.2021.100577

PMCID:: PMC8079274

Abstract Article PDF–2.9M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 58757955.

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

Elizabeth A. Germino, Joseph P. Miller, Lauri Diehl, Carter J. Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H. Miner, Andrey S. Shaw

PLoS One. 2018; 13(3): e0194998. Published online 2018 Mar 29. doi: 10.1371/journal.pone.0194998

PMCID:: PMC5875795

Abstract Article PDF–15M

Select item 58159006.

Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets

Sandip K. Basu, Sook Lee, Jacqueline Salotti, Srikanta Basu, Krisada Sakchaisri, Zhen Xiao, Vijay Walia, Christopher J. Westlake, Deborah K. Morrison, Peter F. Johnson

Cancer Res. Author manuscript; available in PMC 2019 Feb 15.

Published in final edited form as: Cancer Res. 2018 Feb 15; 78(4): 891–908. Published online 2017 Dec 19. doi: 10.1158/0008-5472.CAN-17-2353

PMCID:: PMC5815900

Abstract Article PDF–1.4M

Select item 52799127.

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Lili Guo, Diane L. Costanzo-Garvey, Deandra R. Smith, Beth K. Neilsen, Richard G. MacDonald, Robert E. Lewis

Mol Metab. 2017 Feb; 6(2): 194–205. Published online 2016 Dec 18. doi: 10.1016/j.molmet.2016.12.004

PMCID:: PMC5279912

Abstract Article PDF–3.8M

Select item 52704878.

Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP

Maho Takahashi, Yanping Li, Tara J. Dillon, Philip J. S. Stork

J Biol Chem. 2017 Jan 27; 292(4): 1449–1461. Published online 2016 Dec 21. doi: 10.1074/jbc.M116.768986

PMCID:: PMC5270487

Abstract Article PDF–1.9M

Select item 49176489.

praja2 regulates KSR1 stability and mitogenic signaling

L Rinaldi, R Delle Donne, M Sepe, M Porpora, C Garbi, F Chiuso, A Gallo, S Parisi, L Russo, V Bachmann, R G Huber, E Stefan, T Russo, A Feliciello

Cell Death Dis. 2016 May; 7(5): e2230. Published online 2016 May 19. doi: 10.1038/cddis.2016.109

PMCID:: PMC4917648

Abstract Article PDF–1.5M

Select item 486124910.

The Scaffold Protein KSR1, A Novel Therapeutic Target for the Treatment of Merlin-Deficient Tumors

Lu Zhou, Jade Lyons-Rimmer, Sylwia Ammoun, Jürgen Müller, Edwin Lasonder, Vikram Sharma, Emanuela Ercolano, David Hilton, Ifeoluwatola Taiwo, Magdalena Barczyk, C. Oliver Hanemann

Oncogene. Author manuscript; available in PMC 2016 Dec 30.

Published in final edited form as: Oncogene. 2016 Jun 30; 35(26): 3443–3453. Published online 2015 Nov 9. doi: 10.1038/onc.2015.404

PMCID:: PMC4861249

Abstract Article PDF–2.5M

Select item 413561311.

Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-Ras^V12-Induced Senescence, and Transformation

Robert L. Kortum, Mario R. Fernandez, Diane L. Costanzo-Garvey, Heidi J. Johnson, Kurt W. Fisher, Deanna J. Volle, Robert E. Lewis

Mol Cell Biol. 2014 Sep; 34(18): 3461–3472. doi: 10.1128/MCB.01633-13

PMCID:: PMC4135613

Abstract Article PDF–3.1M

Select item 403850312.

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE)

E. Giurisato, A. Gamberucci, C. Ulivieri, S. Marruganti, E. Rossi, E. Giacomello, D. Randazzo, V. Sorrentino

Mol Biol Cell. 2014 Jun 1; 25(11): 1769–1781. doi: 10.1091/mbc.E13-05-0292

PMCID:: PMC4038503

Abstract Article PDF–5.2M

Select item 389289513.

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation

Che-Hung Shen, Ping Yuan, Rolando Perez-Lorenzo, Yaqing Zhang, Sze Xian Lee, Yang Ou, John M. Asara, Lewis C. Cantley, Bin Zheng

Mol Cell. Author manuscript; available in PMC 2014 Oct 24.

Published in final edited form as: Mol Cell. 2013 Oct 24; 52(2): 161–172. Published online 2013 Oct 3. doi: 10.1016/j.molcel.2013.08.044

PMCID:: PMC3892895

Abstract Article PDF–879K

Select item 385327314.

Tyr⁷²⁸ in the Kinase Domain of the Murine Kinase Suppressor of RAS 1 Regulates Binding and Activation of the Mitogen-activated Protein Kinase Kinase

Claudia Sibilski, Thomas Mueller, Laxmikanth Kollipara, René P. Zahedi, Ulf R. Rapp, Thomas Rudel, Angela Baljuls

J Biol Chem. 2013 Dec 6; 288(49): 35237–35252. Published online 2013 Oct 24. doi: 10.1074/jbc.M113.490235

PMCID:: PMC3853273

Abstract Article PDF–5.1M

Select item 375874915.

Role of Kinase Suppressor of Ras-1 in Lipopolysaccharide-Induced Acute Lung Injury

Xiang Li, Erich Gulbins, Yang Zhang

Cell Physiol Biochem. Author manuscript; available in PMC 2013 Aug 31.

Published in final edited form as: Cell Physiol Biochem. 2012; 30(4): 905–914. Published online 2012 Aug 28. doi: 10.1159/000341468

PMCID:: PMC3758749

Abstract Article PDF–2.8M

Select item 374034916.

A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane

Dorothy Koveal, Natasha Schuh-Nuhfer, Daniel Ritt, Rebecca Page, Deborah K. Morrison, Wolfgang Peti

Sci Signal. Author manuscript; available in PMC 2013 Dec 18.

Published in final edited form as: Sci Signal. 2012 Dec 18; 5(255): ra94. Published online 2012 Dec 18. doi: 10.1126/scisignal.2003289

PMCID:: PMC3740349

Abstract Article PDF–5.1M

Select item 371804317.

Spatially-dependent Dynamic MAPK Modulation by the Nde1-Lis1-Brap Complex Patterns Mammalian CNS

Alison A. Lanctot, Chian-Yu Peng, Ashley S. Pawlisz, Milan Joksimovic, Yuanyi Feng

Dev Cell. Author manuscript; available in PMC 2014 May 13.

Published in final edited form as: Dev Cell. 2013 May 13; 25(3): 241–255. doi: 10.1016/j.devcel.2013.04.006

PMCID:: PMC3718043

Abstract Article PDF–2.9M

Select item 357634818.

Kinase Suppressor of Ras 1 Is Not Required for the Generation of Regulatory and Memory T Cells

Marie Le Borgne, Erin L. Filbert, Andrey S. Shaw

PLoS One. 2013; 8(2): e57137. Published online 2013 Feb 19. doi: 10.1371/journal.pone.0057137

PMCID:: PMC3576348

Abstract Article PDF–1.1M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 343019920.

Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK

Mario R. Fernandez, MaLinda D. Henry, Robert E. Lewis

Mol Cell Biol. 2012 Sep; 32(18): 3718–3731. doi: 10.1128/MCB.06754-11

PMCID:: PMC3430199

Abstract Article PDF–2.1M

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