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Select item 104827491.

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

Ivan Bradić, Laura Liesinger, Katharina B. Kuentzel, Nemanja Vujić, Michael Trauner, Ruth Birner-Gruenberger, Dagmar Kratky

J Lipid Res. 2023 Sep; 64(9): 100427. Published online 2023 Aug 16. doi: 10.1016/j.jlr.2023.100427

PMCID:: PMC10482749

Abstract Article PDF–2.9M

Select item 104036402.

Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth

Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima

Life Sci Alliance. 2023 Oct; 6(10): e202301916. Published online 2023 Aug 4. doi: 10.26508/lsa.202301916

PMCID:: PMC10403640

Abstract Article PDF–2.1M

Select item 95362793.

Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c⁺ myeloid-derived suppressor cells

Ting Zhao, Sheng Liu, Xinchun Ding, Erica M. Johnson, Nasser H. Hanna, Kanhaiya Singh, Chandan K. Sen, Jun Wan, Hong Du, Cong Yan

JCI Insight. 2022 Sep 8; 7(17): e156623. Published online 2022 Sep 8. doi: 10.1172/jci.insight.156623

PMCID:: PMC9536279

Abstract Article PDF–6.5M

Select item 91184734.

Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases

Ivan Bradić, Katharina B. Kuentzel, Sophie Honeder, Gernot F. Grabner, Nemanja Vujić, Robert Zimmermann, Ruth Birner-Gruenberger, Dagmar Kratky

Mol Metab. 2022 Jul; 61: 101510. Published online 2022 Apr 30. doi: 10.1016/j.molmet.2022.101510

PMCID:: PMC9118473

Abstract Article PDF–2.5M

Select item 85565255.

Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet

Michael W. Lopresti, Wenqi Cui, Breann E. Abernathy, Gavin Fredrickson, Fanta Barrow, Arnav S. Desai, Xavier S. Revelo, Douglas G. Mashek

J Lipid Res. 2021; 62: 100133. Published online 2021 Oct 5. doi: 10.1016/j.jlr.2021.100133

PMCID:: PMC8556525

Abstract Article PDF–4.6M

Select item 85338086.

Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase

Vinay Sachdev, Madalina Duta-Mare, Melanie Korbelius, Nemanja Vujić, Christina Leopold, Jan Freark de Boer, Silvia Rainer, Peter Fickert, Dagmar Kolb, Folkert Kuipers, Branislav Radovic, Gregor Gorkiewicz, Dagmar Kratky

Cells. 2021 Oct; 10(10): 2619. Published online 2021 Oct 1. doi: 10.3390/cells10102619

PMCID:: PMC8533808

Abstract Article PDF–14M

Select item 85089857.

Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth

Katharina B. Kuentzel, Ivan Bradić, Alena Akhmetshina, Melanie Korbelius, Silvia Rainer, Dagmar Kolb, Martin Gauster, Nemanja Vujić, Dagmar Kratky

Int J Mol Sci. 2021 Oct; 22(19): 10416. Published online 2021 Sep 27. doi: 10.3390/ijms221910416

PMCID:: PMC8508985

Abstract Article PDF–7.3M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78631369.

Lysosomal Acid Lipase Deficiency Controls T- and B-Regulatory Cell Homeostasis in the Lymph Nodes of Mice with Human Cancer Xenotransplants

Xinchun Ding, Ting Zhao, Chih-Chun Lee, Cong Yan, Hong Du

Am J Pathol. 2021 Feb; 191(2): 353–367. doi: 10.1016/j.ajpath.2020.10.007

PMCID:: PMC7863136

Abstract Article PDF–1.7M

Select item 770635210.

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease

Hung D. Nguyen, Taylor Ticer, David Bastian, Sandeepkumar Kuril, Hong Li, Hong Du, Cong Yan, Xue-Zhong Yu

Cell Rep. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Cell Rep. 2020 Oct 27; 33(4): 108316. doi: 10.1016/j.celrep.2020.108316

PMCID:: PMC7706352

Abstract Article PDF–1.2M

Select item 761581011.

Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase

Valentina Bianco, Monika Svecla, Giovanni Battista Vingiani, Dagmar Kolb, Birgit Schwarz, Martin Buerger, Giangiacomo Beretta, Giuseppe Danilo Norata, Dagmar Kratky

J Proteome Res. 2024 Apr 5; 23(4): 1506–1518. Published online 2024 Feb 29. doi: 10.1021/acs.jproteome.4c00082

PMCID:: PMC7615810

Abstract Article PDF–7.9M

Select item 761552612.

Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice

Alena Akhmetshina, Valentina Bianco, Ivan Bradić, Melanie Korbelius, Anita Pirchheim, Katharina B. Kuentzel, Thomas O. Eichmann, Helga Hinteregger, Dagmar Kolb, Hansjoerg Habisch, Laura Liesinger, Tobias Madl, Wolfgang Sattler, Branislav Radović, Simon Sedej, Ruth Birner-Gruenberger, Nemanja Vujić, Dagmar Kratky

Mol Metab. 2024 Jan; 79: 101869. Published online 2023 Dec 30. doi: 10.1016/j.molmet.2023.101869

PMCID:: PMC7615526

Abstract Article PDF–3.7M

Select item 727995713.

Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation

Carina Wagner, Victoria Hois, Laura Pajed, Lisa-Maria Pusch, Heimo Wolinski, Michael Trauner, Robert Zimmermann, Ulrike Taschler, Achim Lass

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Jun 8.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May 1; 1865(8): 158730. Published online 2020 May 1. doi: 10.1016/j.bbalip.2020.158730

PMCID:: PMC7279957

Abstract Article PDF–2.4M

Select item 655657414.

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Laura Pajed, Carina Wagner, Ulrike Taschler, Renate Schreiber, Stephanie Kolleritsch, Nermeen Fawzy, Isabella Pototschnig, Gabriele Schoiswohl, Lisa-Maria Pusch, Beatrix I. Wieser, Paul Vesely, Gerald Hoefler, Thomas O. Eichmann, Robert Zimmermann, Achim Lass

J Biol Chem. 2019 Jun 7; 294(23): 9118–9133. Published online 2019 Apr 25. doi: 10.1074/jbc.RA118.007201

PMCID:: PMC6556574

Abstract Article PDF–3.3M

Select item 637207715.

Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation

Christina Leopold, Madalina Duta-Mare, Vinay Sachdev, Madeleine Goeritzer, Lisa Katharina Maresch, Dagmar Kolb, Helga Reicher, Bettina Wagner, Tatjana Stojakovic, Thomas Ruelicke, Guenter Haemmerle, Gerald Hoefler, Wolfgang Sattler, Dagmar Kratky

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr; 1864(4): 500–511. Published online 2019 Jan 9. doi: 10.1016/j.bbalip.2019.01.007

PMCID:: PMC6372077

Abstract Article PDF–2.8M

Select item 592071616.

Lysosomal acid lipase promotes reverse cholesterol transport in vitro and in vivo

Kristin L. Bowden, Joshua A. Dubland, Teddy Chan, You-Hai Xu, Gregory A. Grabowski, Hong Du, Gordon A. Francis

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 May; 38(5): 1191–1201. Published online 2018 Mar 29. doi: 10.1161/ATVBAHA.117.310507

PMCID:: PMC5920716

Abstract Article PDF–991K

Select item 583946417.

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

Madalina Duta-Mare, Vinay Sachdev, Christina Leopold, Dagmar Kolb, Nemanja Vujic, Melanie Korbelius, Dina C. Hofer, Wenmin Xia, Katharina Huber, Martina Auer, Benjamin Gottschalk, Christoph Magnes, Wolfgang F. Graier, Andreas Prokesch, Branislav Radovic, Juliane G. Bogner-Strauss, Dagmar Kratky

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2018 Apr; 1863(4): 467–478. Published online 2018 Jan 31. doi: 10.1016/j.bbalip.2018.01.011

PMCID:: PMC5839464

Abstract Article PDF–2.4M

Select item 570266218.

Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase–deficient mice

Ting Zhao, Xinchun Ding, Cong Yan, Hong Du

J Biol Chem. 2017 Nov 24; 292(47): 19198–19208. Published online 2017 Sep 18. doi: 10.1074/jbc.M116.773093

PMCID:: PMC5702662

Abstract Article PDF–1.8M

Select item 552232519.

Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages

Stefanie Schlager, Nemanja Vujic, Melanie Korbelius, Madalina Duta-Mare, Juliane Dorow, Christina Leopold, Silvia Rainer, Martin Wegscheider, Helga Reicher, Uta Ceglarek, Wolfgang Sattler, Branislav Radovic, Dagmar Kratky

Oncotarget. 2017 Jun 20; 8(25): 40037–40051. Published online 2017 Mar 29. doi: 10.18632/oncotarget.16673

PMCID:: PMC5522325

Abstract Article PDF–5.3M

Select item 517336620.

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

Fahd O. Ismael, Tessa J. Barrett, Diba Sheipouri, Bronwyn E. Brown, Michael J. Davies, Clare L. Hawkins

PLoS One. 2016; 11(12): e0168844. Published online 2016 Dec 20. doi: 10.1371/journal.pone.0168844

PMCID:: PMC5173366

Abstract Article PDF–1.7M

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