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Items: 1 to 20 of 86

1.
NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6–driven pyroptosis and inflammation
Mingwei Sheng, Shuhan Huo, Lili Jia, Yiqi Weng, Weihua Liu, Yuanbang Lin, Wenli Yu
Hepatol Commun. 2024 Jul; 8(7): e0479. Published online 2024 Jul 5. doi: 10.1097/HC9.0000000000000479
PMCID:
PMC11227355
AbstractArticlePDF–1.8M
2.
Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation
Yuanbang Lin, Mingwei Sheng, Hua Qin, Peng Zhang, Chunli Wang, Wei Fu, Xiangjun Meng, Duowei Wang, Yachao Hou
Cell Commun Signal. 2023; 21: 282. Published online 2023 Oct 12. doi: 10.1186/s12964-023-01287-x
PMCID:
PMC10568785
AbstractArticlePDF–12M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making
Jun Zhu, Yanlong Shi, Sheng Lan, Jingyan Wang, Fei Jiang, Caiping Tang, Yuan Cai, Ziyuan Pan, Haokun Jian, Hanlu Fang, Yewei Zhang, Fei Zhong
Apoptosis. 2023; 28(5-6): 769–782. Published online 2023 Mar 7. doi: 10.1007/s10495-023-01823-7
PMCID:
PMC10232623
AbstractArticlePDF–8.3M
5.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
6.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
7.
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
Libin Zhou, Kwangsik Nho, Maria G. Haddad, Nicole Cherepacha, Agne Tubeleviciute-Aydin, Andy P. Tsai, Andrew J. Saykin, P. Jesper Sjöström, Andrea C. LeBlanc
Sci Rep. 2021; 11: 12695. Published online 2021 Jun 16. doi: 10.1038/s41598-021-91367-0
Correction in:
Sci Rep. 2021; 11: 16151.
PMCID:
PMC8209045
AbstractArticlePDF–4.1M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Peng Zhao, Xiaoli Sun, Cynthia Chaggan, Zhongji Liao, Kai in Wong, Feng He, Seema Singh, Rohit Loomba, Michael Karin, Joseph L. Witztum, Alan R. Saltiel
Science. Author manuscript; available in PMC 2021 Mar 31.
Published in final edited form as: Science. 2020 Feb 7; 367(6478): 652–660. doi: 10.1126/science.aay0542
PMCID:
PMC8012106
AbstractArticlePDF–2.5M
10.
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits
Anastasia Noël, Bénédicte Foveau, Andréa C. LeBlanc
Cell Death Dis. 2021 Mar; 12(3): 227. Published online 2021 Mar 1. doi: 10.1038/s41419-021-03506-0
PMCID:
PMC7921451
AbstractArticlePDF–3.6M
11.
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti
Cell. Author manuscript; available in PMC 2021 Apr 30.
Published in final edited form as: Cell. 2020 Apr 30; 181(3): 674–687.e13. Published online 2020 Apr 15. doi: 10.1016/j.cell.2020.03.040
PMCID:
PMC7425208
AbstractArticlePDF–2.7M
12.
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation
Todd Douglas, Maya Saleh
J Biol Chem. 2020 Apr 17; 295(16): 5216–5228. Published online 2020 Mar 2. doi: 10.1074/jbc.RA119.011622
PMCID:
PMC7170516
AbstractArticlePDF–4.0M
13.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
14.
Proteomic analysis on structural proteins of Severe Acute Respiratory Syndrome coronavirus
Wantao Ying, Yunwei Hao, Yangjun Zhang, Wenming Peng, Ede Qin, Yun Cai, Kaihua Wei, Jie Wang, Guohui Chang, Wei Sun, Shujia Dai, Xiaohai Li, Yunping Zhu, Jianqi Li, Songfeng Wu, Lihai Guo, Jingquan Dai, Jinglan Wang, Ping Wan, Tinggui Chen, Chunjuan Du, Dong Li, Jia Wan, Xuezhang Kuai, Weihua Li, Rong Shi, Handong Wei, Cheng Cao, Man Yu, Hong Liu, Fangting Dong, Donggen Wang, Xuemin Zhang, Xiaohong Qian, Qingyu Zhu, Fuchu He
Proteomics. 2004 Feb; 4(2): 492–504. Published online 2004 Jan 15. doi: 10.1002/pmic.200300676
PMCID:
PMC7168022
AbstractArticlePDF–191K
15.
Cell Type-Specific Cleavage of Nucleocapsid Protein by Effector Caspases during SARS Coronavirus Infection
Claudia Diemer, Martha Schneider, Judith Seebach, Janine Quaas, Gert Frösner, Hermann M. Schätzl, Sabine Gilch
J Mol Biol. 2008 Feb 8; 376(1): 23–34. Published online 2007 Dec 4. doi: 10.1016/j.jmb.2007.11.081
PMCID:
PMC7094231
AbstractArticlePDF–1.1M
16.
De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance
Zi-Yuan Nie, Min Yao, Zhan Yang, Lin Yang, Xiao-Jun Liu, Jing Yu, Ying Ma, Nan Zhang, Xiao-Yan Zhang, Meng-Han Liu, Ling-Ling Jiang, Jian-Min Luo
J Exp Clin Cancer Res. 2020; 39: 17. Published online 2020 Jan 17. doi: 10.1186/s13046-019-1502-7
PMCID:
PMC6969434
AbstractArticlePDF–2.4M
17.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
18.
Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease
Peleg M. Horowitz, Kristina R. Patterson, Angela L. Guillozet-Bongaarts, Matthew R. Reynolds, Christopher A. Carroll, Susan T. Weintraub, David A. Bennett, Vincent L. Cryns, Robert W. Berry, Lester I. Binder
J Neurosci. 2004 Sep 8; 24(36): 7895–7902. doi: 10.1523/JNEUROSCI.1988-04.2004
PMCID:
PMC6729917
AbstractArticlePDF–553K
19.
Specificity for latent C-termini links the E3 ubiquitin ligase CHIP to caspases
Matthew Ravalin, Panagiotis Theofilas, Koli Basu, Kwadwo A. Opoku-Nsiah, Victoria A. Assimon, Daniel Medina-Cleghorn, Yi-Fan Chen, Markus F. Bohn, Michelle Arkin, Lea T. Grinberg, Charles S. Craik, Jason E. Gestwicki
Nat Chem Biol. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: Nat Chem Biol. 2019 Aug; 15(8): 786–794. Published online 2019 Jul 18. doi: 10.1038/s41589-019-0322-6
PMCID:
PMC6693490
AbstractArticlePDF–1.6M
20.
Identification of Allosteric Inhibitors against Active Caspase-6
Agne Tubeleviciute-Aydin, Alexandre Beautrait, Jeffrey Lynham, Gyanesh Sharma, Alexei Gorelik, Ludovic J. Deny, Naoto Soya, Gergely L. Lukacs, Bhushan Nagar, Anne Marinier, Andrea C. LeBlanc
Sci Rep. 2019; 9: 5504. Published online 2019 Apr 2. doi: 10.1038/s41598-019-41930-7
PMCID:
PMC6445123
AbstractArticlePDF–7.2M

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