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Select item 110037431.

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

Preksha Gaur, Yesheswini Rajendran, Bhagyashree Srivastava, Manasvini Markandey, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Aamir Suhail, Shikha Chaudhary, Shaifali Tyagi, Subhash Chandra Yadav, Amit Kumar Pandey, Yifat Merbl, Avinash Bajaj, Vineet Ahuja, Chittur Srikanth

eLife. 2024; 12: RP89776. Published online 2024 Apr 9. doi: 10.7554/eLife.89776

PMCID:: PMC11003743

Abstract Article PDF–11M

Select item 101516152.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 70504723.

Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement

Kayla N. Berry, Tom J. Brett

Cell Rep. Author manuscript; available in PMC 2020 Mar 2.

Published in final edited form as: Cell Rep. 2020 Jan 28; 30(4): 1141–1151.e3. Published online 2020 Jan 28. doi: 10.1016/j.celrep.2019.12.059

PMCID:: PMC7050472

Abstract Article PDF–2.2M

Select item 68513004.

Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties

Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E. V. Johansson

J Biol Chem. 2019 Nov 8; 294(45): 17075–17089. Published online 2019 Sep 29. doi: 10.1074/jbc.RA119.009940

PMCID:: PMC6851300

Abstract Article PDF–3.1M

Select item 60855405.

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

Elisabeth E.L. Nyström, George M.H. Birchenough, Sjoerd van der Post, Liisa Arike, Achim D. Gruber, Gunnar C. Hansson, Malin E.V. Johansson

EBioMedicine. 2018 Jul; 33: 134–143. Published online 2018 Jun 7. doi: 10.1016/j.ebiom.2018.05.031

PMCID:: PMC6085540

Abstract Article PDF–2.3M

Select item 56274836.

CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway

Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu, Shu Zheng

Cell Commun Signal. 2017; 15: 38. Published online 2017 Oct 3. doi: 10.1186/s12964-017-0192-z

PMCID:: PMC5627483

Abstract Article PDF–2.2M

Select item 54540997.

Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1)

Monica Sala-Rabanal, Zeynep Yurtsever, Kayla N. Berry, Colin G. Nichols, Tom J. Brett

J Biol Chem. 2017 Jun 2; 292(22): 9164–9174. Published online 2017 Apr 18. doi: 10.1074/jbc.M117.788232

PMCID:: PMC5454099

Abstract Article PDF–2.2M

Select item 46543328.

Low Expression of Chloride Channel Accessory 1 Predicts a Poor Prognosis in Colorectal Cancer

Bo Yang, Lin Cao, Jiaen Liu, Yanjie Xu, Gillian Milne, Wanhei Chan, Steven D Heys, Colin D McCaig, Jin Pu

Cancer. 2015 May 15; 121(10): 1570–1580. Published online 2015 Jan 20. doi: 10.1002/cncr.29235

PMCID:: PMC4654332

Abstract Article PDF–542K

Select item 44980619.

Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1)

Natasha Musrap, Alessandra Tuccitto, George S. Karagiannis, Punit Saraon, Ihor Batruch, Eleftherios P. Diamandis

J Biol Chem. 2015 Jul 10; 290(28): 17218–17227. Published online 2015 May 24. doi: 10.1074/jbc.M115.639773

PMCID:: PMC4498061

Abstract Article PDF–1.1M

Select item 436065310.

Secreted CLCA1 modulates TMEM16A to activate Ca²⁺-dependent chloride currents in human cells

Monica Sala-Rabanal, Zeynep Yurtsever, Colin G Nichols, Tom J Brett

eLife. 2015; 4: e05875. Published online 2015 Mar 17. doi: 10.7554/eLife.05875

PMCID:: PMC4360653

Abstract Article PDF–2.8M

Select item 386148211.

Secreted hCLCA1 Is a Signaling Molecule That Activates Airway Macrophages

John C. H. Ching, Liubov Lobanova, Matthew E. Loewen

PLoS One. 2013; 8(12): e83130. Published online 2013 Dec 12. doi: 10.1371/journal.pone.0083130

PMCID:: PMC3861482

Abstract Article PDF–2.8M

Select item 362518612.

The Transition from Proliferation to Differentiation in Colorectal Cancer Is Regulated by the Calcium Activated Chloride Channel A1

Bo Yang, Lin Cao, Bin Liu, Colin D. McCaig, Jin Pu

PLoS One. 2013; 8(4): e60861. Published online 2013 Apr 12. doi: 10.1371/journal.pone.0060861

PMCID:: PMC3625186

Abstract Article PDF–5.3M

Select item 351675913.

Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation

Zeynep Yurtsever, Monica Sala-Rabanal, David T. Randolph, Suzanne M. Scheaffer, William T. Roswit, Yael G. Alevy, Anand C. Patel, Richard F. Heier, Arthur G. Romero, Colin G. Nichols, Michael J. Holtzman, Tom J. Brett

J Biol Chem. 2012 Dec 7; 287(50): 42138–42149. Published online 2012 Oct 30. doi: 10.1074/jbc.M112.410282

PMCID:: PMC3516759

Abstract Article PDF–4.3M

Select item 348969714.

Increased human Ca²⁺-activated Cl^- channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients

Hiroki Iwashita, Keisaku Fujimoto, Shigeru Morita, Atsushi Nakanishi, Keishi Kubo

Respir Res. 2012; 13(1): 55. Published online 2012 Jun 25. doi: 10.1186/1465-9921-13-55

PMCID:: PMC3489697

Abstract Article PDF–1.4M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316916716.

Risk of Meningioma and Common Variation in Genes related to Innate Immunity

Preetha Rajaraman, Alina V. Brenner, Gila Neta, Ruth Pfeiffer, Sophia S. Wang, Meredith Yeager, Gilles Thomas, Howard A. Fine, Martha S. Linet, Nathaniel Rothman, Stephen J. Chanock, Peter D. Inskip

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Sep 7.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5): 1356–1361. Published online 2010 Apr 20. doi: 10.1158/1055-9965.EPI-09-1151

PMCID:: PMC3169167

Abstract Article PDF–61K

Select item 313914717.

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

Mary Ann Checkley, Benjamin G. Luttge, Eric O. Freed

J Mol Biol. Author manuscript; available in PMC 2012 Jul 22.

Published in final edited form as: J Mol Biol. 2011 Jul 22; 410(4): 582–608. doi: 10.1016/j.jmb.2011.04.042

PMCID:: PMC3139147

Abstract Article PDF–2.3M

Select item 296777018.

Polymorphisms in innate immunity genes and risk of childhood leukemia

Sohee Han, Qing Lan, Ae Kyung Park, Kyoung-Mu Lee, Sue K. Park, Hyo Seop Ahn, Hee Young Shin, Hyoung Jin Kang, Hong Hoe Koo, Jong Jin Seo, Ji Eun Choi, Yoon-Ok Ahn, Stephen J. Chanock, Ho Kim, Nathaniel Rothman, Daehee Kang

Hum Immunol. Author manuscript; available in PMC 2010 Nov 2.

Published in final edited form as: Hum Immunol. 2010 Jul; 71(7): 727–730. Published online 2010 May 16. doi: 10.1016/j.humimm.2010.04.004

PMCID:: PMC2967770

Abstract Article PDF–306K

Select item 294516819.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583220.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

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