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Items: 1 to 20 of 44

1.
SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space
M. Beter, A. Abdollahzadeh, H. H. Pulkkinen, H. Huang, F. Orsenigo, P. U. Magnusson, S. Ylä-Herttuala, J. Tohka, J. P. Laakkonen
Sci Rep. 2023; 13: 7279. Published online 2023 May 4. doi: 10.1038/s41598-023-33090-6
PMCID:
PMC10160097
AbstractArticlePDF–9.9M
2.
Circulating plasma miRNA homologs in mice and humans reflect familial cerebral cavernous malformation disease
Sharbel G. Romanos, Abhinav Srinath, Ying Li, Bingqing Xie, Chang Chen, Yan Li, Thomas Moore, Dehua Bi, Je Yeong Sone, Rhonda Lightle, Nick Hobson, Dongdong Zhang, Janne Koskimäki, Le Shen, Sara McCurdy, Catherine Chinhchu Lai, Agnieszka Stadnik, Kristina Piedad, Julián Carrión-Penagos, Abdallah Shkoukani, Daniel Snellings, Robert Shenkar, Dinanath Sulakhe, Yuan Ji, Miguel A. Lopez-Ramirez, Mark L. Kahn, Douglas A. Marchuk, Mark H. Ginsberg, Romuald Girard, Issam A. Awad
Transl Stroke Res. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Transl Stroke Res. 2023 Aug; 14(4): 513–529. Published online 2022 Jun 17. doi: 10.1007/s12975-022-01050-3
PMCID:
PMC9758276
AbstractArticlePDF–1.3M
3.
Transcriptome Analysis Reveals Altered Expression of Genes Involved in Hypoxia, Inflammation and Immune Regulation in Pdcd10-Depleted Mouse Endothelial Cells
Carmela Fusco, Grazia Nardella, Lucio Di Filippo, Elisabetta Dejana, Davide Cacchiarelli, Antonio Petracca, Lucia Micale, Matteo Malinverno, Marco Castori
Genes (Basel) 2022 Jun; 13(6): 961. Published online 2022 May 27. doi: 10.3390/genes13060961
PMCID:
PMC9222422
AbstractArticlePDF–2.4M
4.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
5.
CCM3 loss-induced lymphatic defect is mediated by the augmented VEGFR3-ERK1/2 signaling
Lingfeng Qin, Haifeng Zhang, Busu Li, Quan Jiang, Francesc Lopez, Wang Min, Jenny Huanjiao Zhou
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Dec; 41(12): 2943–2960. Published online 2021 Oct 21. doi: 10.1161/ATVBAHA.121.316707
PMCID:
PMC8613000
AbstractArticlePDF–2.8M
6.
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng
JCI Insight. 2021 Jun 22; 6(12): e142838. Published online 2021 Jun 22. doi: 10.1172/jci.insight.142838
PMCID:
PMC8262504
AbstractArticlePDF–6.9M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min
Nat Commun. 2021; 12: 504. Published online 2021 Jan 25. doi: 10.1038/s41467-020-20774-0
PMCID:
PMC7835246
AbstractArticlePDF–9.7M
9.
Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution
Fabrizio Orsenigo, Lei Liu Conze, Suvi Jauhiainen, Monica Corada, Francesca Lazzaroni, Matteo Malinverno, Veronica Sundell, Sara Isabel Cunha, Johan Brännström, Maria Ascención Globisch, Claudio Maderna, Maria Grazia Lampugnani, Peetra Ulrica Magnusson, Elisabetta Dejana
eLife. 2020; 9: e61413. Published online 2020 Nov 3. doi: 10.7554/eLife.61413
PMCID:
PMC7609066
AbstractArticlePDF–11M
10.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn
J Exp Med. 2020 Oct 5; 217(10): e20200140. Published online 2020 Jul 10. doi: 10.1084/jem.20200140
PMCID:
PMC7537394
AbstractArticlePDF–7.2M
11.
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
Alan T. Tang, Katie R. Sullivan, Courtney C. Hong, Lauren M. Goddard, Aparna Mahadevan, Aileen Ren, Heidy Pardo, Amy Peiper, Erin Griffin, Ceylan Tanes, Lisa M. Mattei, Jisheng Yang, Li Li, Patricia Mericko-Ishizuka, Le Shen, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Claudia J. Roedel, Ning Li, Qin Zhu, Kevin J. Whitehead, Xiangjian Zheng, Amy Akers, Leslie Morrison, Helen Kim, Kyle Bittinger, Christopher J. Lengner, Markus Schwaninger, Anna Velcich, Leonard Augenlicht, Salim Abdelilah-Seyfried, Wang Min, Douglas A. Marchuk, Issam A. Awad, Mark L. Kahn
Sci Transl Med. Author manuscript; available in PMC 2019 Dec 31.
Published in final edited form as: Sci Transl Med. 2019 Nov 27; 11(520): eaaw3521. doi: 10.1126/scitranslmed.aaw3521
PMCID:
PMC6937779
AbstractArticlePDF–3.6M
12.
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad
Acta Neuropathol Commun. 2019; 7: 132. Published online 2019 Aug 19. doi: 10.1186/s40478-019-0789-0
PMCID:
PMC6699077
AbstractArticlePDF–4.5M
13.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
14.
Endothelial cell clonal expansion in the development of cerebral cavernous malformations
Matteo Malinverno, Claudio Maderna, Abdallah Abu Taha, Monica Corada, Fabrizio Orsenigo, Mariaelena Valentino, Federica Pisati, Carmela Fusco, Paolo Graziano, Monica Giannotta, Qing Cissy Yu, Yi Arial Zeng, Maria Grazia Lampugnani, Peetra U. Magnusson, Elisabetta Dejana
Nat Commun. 2019; 10: 2761. Published online 2019 Jun 24. doi: 10.1038/s41467-019-10707-x
PMCID:
PMC6591323
AbstractArticlePDF–17M
15.
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes
Janne Koskimäki, Romuald Girard, Yan Li, Laleh Saadat, Hussein A. Zeineddine, Rhonda Lightle, Thomas Moore, Seán Lyne, Kenneth Avner, Robert Shenkar, Ying Cao, Changbin Shi, Sean P. Polster, Dongdong Zhang, Julián Carrión-Penagos, Sharbel Romanos, Gregory Fonseca, Miguel A. Lopez-Ramirez, Eric M. Chapman, Evelyn Popiel, Alan T. Tang, Amy Akers, Pieter Faber, Jorge Andrade, Mark Ginsberg, W. Brent Derry, Mark L. Kahn, Douglas A. Marchuk, Issam A. Awad
JCI Insight. 2019 Feb 7; 4(3): e126167. Published online 2019 Feb 7. doi: 10.1172/jci.insight.126167
PMCID:
PMC6413775
AbstractArticlePDF–4.6M
16.
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimäki, Sean Polster, Laleh Saadat, Ignacio A. Romero, Charles T. Esmon, Frederic Lagarrigue, Issam A. Awad, Laurent O. Mosnier, Mark H. Ginsberg
Blood. 2019 Jan 17; 133(3): 193–204. Prepublished online 2018 Nov 15. doi: 10.1182/blood-2018-06-856062
PMCID:
PMC6337879
AbstractArticle
17.
Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure
Allison M. Johnson, James P. Roach, Anna Hu, Svetlana M. Stamatovic, Michal R. Zochowski, Richard F. Keep, Anuska V. Andjelkovic
FASEB J. 2018 May; 32(5): 2615–2629. Published online 2018 Jan 8. doi: 10.1096/fj.201700699R
PMCID:
PMC5901390
AbstractArticle
18.
Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
Sayoko Nishimura, Ketu Mishra-Gorur, JinSeok Park, Yulia V. Surovtseva, Said M. Sebti, Andre Levchenko, Angeliki Louvi, Murat Gunel
Proc Natl Acad Sci U S A. 2017 May 23; 114(21): 5503–5508. Published online 2017 May 12. doi: 10.1073/pnas.1702942114
PMCID:
PMC5448170
AbstractArticlePDF–1.6M
19.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase
Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong
EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500
PMCID:
PMC5341520
AbstractArticlePDF–1.1M
20.
Augmented endothelial exocytosis of angiopoietin-2 resulting from CCM3-deficiency contributes to the progression of cerebral cavernous malformation
Huanjiao Jenny Zhou, Lingfeng Qin, Haifeng Zhang, Wenwen Tang, Weidong Ji, Yun He, Xiaoling Liang, Zongren Wang, Qianying Yuan, Alexander Vortmeyer, Derek Toomre, Germaine Fuh, Minghong Yan, Martin S. Kluger, Dianqing Wu, Wang Min
Nat Med. Author manuscript; available in PMC 2017 Mar 1.
Published in final edited form as: Nat Med. 2016 Sep; 22(9): 1033–1042. Published online 2016 Aug 22. doi: 10.1038/nm.4169
PMCID:
PMC5014607
AbstractArticlePDF–2.2M

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