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Select item 108640211.

GCN2 is required to maintain core body temperature in mice during acute cold

Jordan L. Levy, Emily T. Mirek, Esther M. Rodriguez, Brian Zalma, Jeffrey Burns, William O. Jonsson, Harini Sampath, Kirk A. Staschke, Ronald C. Wek, Tracy G. Anthony

Am J Physiol Endocrinol Metab. 2023 Nov 1; 325(5): E624–E637. Published online 2023 Oct 4. doi: 10.1152/ajpendo.00181.2023

PMCID:: PMC10864021

Abstract Article

Select item 94363092.

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages

Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho, Soroush Tahmasebi

Proc Natl Acad Sci U S A. 2022 Aug 30; 119(35): e2121251119. Published online 2022 Aug 22. doi: 10.1073/pnas.2121251119

PMCID:: PMC9436309

Abstract Article PDF–2.3M

Select item 93964073.

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R. Dufour, Duckgue Lee, Negar Tabatabaei, Phoenix Toboz, Ernest Radovani, Jack F. Greenblatt, Jalees Rehman, Jacob Class, Arkady Khoutorsky, Bruno D. Fonseca, Justin M. Richner, Eloi Mercier, Guillaume Bourque, Vincent Giguère, Arvind R. Subramaniam, Jaeseok Han, Soroush Tahmasebi

J Biol Chem. 2022 Sep; 298(9): 102277. Published online 2022 Jul 19. doi: 10.1016/j.jbc.2022.102277

PMCID:: PMC9396407

Abstract Article PDF–2.9M

Select item 92049504.

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific

William O. Jonsson, Emily T. Mirek, Ronald C. Wek, Tracy G. Anthony

FASEB J. 2022 Jul; 36(7): e22396. Published online 2022 Jun 12. doi: 10.1096/fj.202200204RR

PMCID:: PMC9204950

Abstract Article PDF–704K

Select item 91122885.

PERK is a critical metabolic hub for immunosuppressive function in macrophages

Lydia N. Raines, Haoxin Zhao, Yuzhu Wang, Heng-Yi Chen, Hector Gallart-Ayala, Pei-Chun Hsueh, Wei Cao, Yeojung Koh, Ana Alamonte-Loya, Pu-Ste Liu, Julijana Ivanisevic, Chan-Wang Jerry Lio, Ping-Chih Ho, Stanley Ching-Cheng Huang

Nat Immunol. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Nat Immunol. 2022 Mar; 23(3): 431–445. Published online 2022 Feb 28. doi: 10.1038/s41590-022-01145-x

PMCID:: PMC9112288

Abstract Article PDF–2.4M

Select item 90156996.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Abstract Article PDF–3.3M

Select item 89617227.

GCN2 adapts protein synthesis to scavenging-dependent growth

Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz

Cell Syst. Author manuscript; available in PMC 2022 Aug 16.

Published in final edited form as: Cell Syst. 2022 Feb 16; 13(2): 158–172.e9. Published online 2021 Oct 26. doi: 10.1016/j.cels.2021.09.014

PMCID:: PMC8961722

Abstract Article PDF–2.6M

Select item 89085468.

The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy

E. L. Spaulding, T. J. Hines, P. Bais, A. L. D. Tadenev, R. Schneider, D. Jewett, B. Pattavina, S. L. Pratt, K. H. Morelli, M. G. Stum, D. P. Hill, C. Gobet, M. Pipis, M. M. Reilly, M. J. Jennings, R. Horvath, Y. Bai, M. E. Shy, B. Alvarez-Castelao, E. M. Schuman, L. P. Bogdanik, E. Storkebaum, R. W. Burgess

Science. Author manuscript; available in PMC 2022 Sep 3.

Published in final edited form as: Science. 2021 Sep 3; 373(6559): 1156–1161. Published online 2021 Sep 1. doi: 10.1126/science.abb3414

PMCID:: PMC8908546

Abstract Article PDF–1.4M

Select item 87186699.

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu

Redox Biol. 2022 Feb; 49: 102224. Published online 2021 Dec 22. doi: 10.1016/j.redox.2021.102224

PMCID:: PMC8718669

Abstract Article PDF–17M

Select item 855453310.

The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids

Rebecca R. Miles, Parth H. Amin, Miguel Barriera Diaz, Jagannath Misra, Erica Aukerman, Amitava Das, Nandini Ghosh, Tanner Guith, Michael D. Knierman, Sashwati Roy, Dan F Spandau, Ronald C. Wek

J Biol Chem. 2021 Nov; 297(5): 101257. Published online 2021 Sep 29. doi: 10.1016/j.jbc.2021.101257

PMCID:: PMC8554533

Abstract Article PDF–4.0M

Select item 853388411.

The Role of Indoleamine 2,3-Dioxygenase in Renal Tubular Epithelial Cells Senescence under Anoxia or Reoxygenation

Theodoros Eleftheriadis, Georgios Pissas, Georgios Filippidis, Vassilios Liakopoulos, Ioannis Stefanidis

Biomolecules. 2021 Oct; 11(10): 1522. Published online 2021 Oct 15. doi: 10.3390/biom11101522

PMCID:: PMC8533884

Abstract Article PDF–3.5M

Select item 819176312.

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Jagannath Misra, Michael J Holmes, Emily T. Mirek, Michael Langevin, Hyeong-Geug Kim, Kenneth R Carlson, Malcolm Watford, X Charlie Dong, Tracy G Anthony, Ronald C Wek

Nucleic Acids Res. 2021 Jun 4; 49(10): 5726–5742. Published online 2021 May 22. doi: 10.1093/nar/gkab362

PMCID:: PMC8191763

Abstract Article PDF–7.5M

Select item 810236013.

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

Deyang Yu, Nicole E. Richardson, Cara L. Green, Alexandra B. Spicer, Michaela E. Murphy, Victoria Flores, Cholsoon Jang, Ildiko Kasza, Maria Nikodemova, Matthew H. Wakai, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Heidi H. Pak, Jacqueline A. Brinkman, Jennifer M. Rojas, William J. Quinn, III, Eunhae P. Cheng, Elizabeth N. Konon, Lexington R. Haider, Megan Finke, Michelle Sonsalla, Caroline M. Alexander, Joshua D. Rabinowitz, Joseph A. Baur, Kristen C. Malecki, Dudley W. Lamming

Cell Metab. Author manuscript; available in PMC 2022 May 4.

Published in final edited form as: Cell Metab. 2021 May 4; 33(5): 905–922.e6. Published online 2021 Apr 21. doi: 10.1016/j.cmet.2021.03.025

PMCID:: PMC8102360

Abstract Article PDF–3.3M

Select item 785452414.

Maternal Immune Activation in Mice Disrupts Proteostasis in the Fetal Brain

Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh

Nat Neurosci. Author manuscript; available in PMC 2021 Jun 23.

Published in final edited form as: Nat Neurosci. 2021 Feb; 24(2): 204–213. Published online 2020 Dec 23. doi: 10.1038/s41593-020-00762-9

PMCID:: PMC7854524

Abstract Article PDF–5.7M

Select item 770794615.

GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis

Xueting Luo, Xiaowei Shi, Zhongguang Sun, Jing Xiao, Hui Song, Guo Lu, Xin Xu

Biomed Res Int. 2020; 2020: 1454396. Published online 2020 Nov 24. doi: 10.1155/2020/1454396

PMCID:: PMC7707946

Abstract Article PDF–1.0M

Select item 768856316.

The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice

Guoli Hu, Yilin Yu, Yuning J Tang, Colleen Wu, Fanxin Long, Courtney M Karner

J Bone Miner Res. Author manuscript; available in PMC 2020 Dec 9.

Published in final edited form as: J Bone Miner Res. 2020 Oct; 35(10): 2004–2014. Published online 2020 Jul 6. doi: 10.1002/jbmr.4091

PMCID:: PMC7688563

Abstract Article PDF–2.3M

Select item 766588817.

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

Markus Terrey, Scott I Adamson, Alana L Gibson, Tianda Deng, Ryuta Ishimura, Jeffrey H Chuang, Susan L Ackerman

eLife. 2020; 9: e62731. Published online 2020 Nov 13. doi: 10.7554/eLife.62731

Correction in:: eLife. 2021; 10: e70785.

PMCID:: PMC7665888

Abstract Article PDF–5.6M

Select item 757289818.

Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

Mridu Kapur, Archan Ganguly, Gabor Nagy, Scott I. Adamson, Jeffrey H. Chuang, Wayne N. Frankel, Susan L. Ackerman

Neuron. Author manuscript; available in PMC 2021 Oct 14.

Published in final edited form as: Neuron. 2020 Oct 14; 108(1): 193–208.e9. Published online 2020 Aug 26. doi: 10.1016/j.neuron.2020.07.023

PMCID:: PMC7572898

Abstract Article PDF–2.1M

Select item 727507419.

Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation

Feixiang Yuan, Haizhou Jiang, Hanrui Yin, Xiaoxue Jiang, Fuxin Jiao, Shanghai Chen, Hao Ying, Yan Chen, Qiwei Zhai, Feifan Guo

Nat Commun. 2020; 11: 2847. Published online 2020 Jun 5. doi: 10.1038/s41467-020-16662-2

PMCID:: PMC7275074

Abstract Article PDF–2.4M

Select item 725301620.

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels

Ayumi Kanno, Shun-ichiro Asahara, Ayuko Furubayashi, Katsuhisa Masuda, Risa Yoshitomi, Emi Suzuki, Tomoko Takai, Maki Kimura-Koyanagi, Tomokazu Matsuda, Alberto Bartolome, Yushi Hirota, Norihide Yokoi, Yuka Inaba, Hiroshi Inoue, Michihiro Matsumoto, Kenichi Inoue, Takaya Abe, Fan-Yan Wei, Kazuhito Tomizawa, Wataru Ogawa, Susumu Seino, Masato Kasuga, Yoshiaki Kido

JCI Insight. 2020 May 7; 5(9): e128820. Published online 2020 May 7. doi: 10.1172/jci.insight.128820

PMCID:: PMC7253016

Abstract Article PDF–15M

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