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Items: 1 to 20 of 128

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model
Shen Zhong, Jürgen Borlak
eBioMedicine. 2023 Sep; 95: 104763. Published online 2023 Aug 23. doi: 10.1016/j.ebiom.2023.104763
PMCID:
PMC10470261
AbstractArticlePDF–8.0M
3.
SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus
Wenwen Geng, Meiling Cao, Ke Dong, Junhua An, Haidong Gao
Cancer Biol Ther. 2023; 24(1): 2206362. Published online 2023 May 11. doi: 10.1080/15384047.2023.2206362
PMCID:
PMC10177683
AbstractArticlePDF–2.5M
4.
COMPLETE REGRESSION OF ADVANCED PANCREATIC DUCTAL ADENOCARCINOMAS UPON COMBINED INHIBITION OF EGFR AND C-RAF
María Teresa Blasco, Carolina Navas, Guillermo Martín-Serrano, Osvaldo Graña-Castro, Carmen G. Lechuga, Laura Martín-Díaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Patón, Emilie Bousquet-Mur, Eva Castellano, Harrys K.C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno Sainz, Jr., Nelson Dusetti, Juan Iovanna, Francisco Sánchez-Bueno, Manuel Hidalgo, Hossein Khiabanian, Raul Rabadán, Fátima Al-Shahrour, Carmen Guerra, Mariano Barbacid
Cancer Cell. Author manuscript; available in PMC 2023 Apr 26.
Published in final edited form as: Cancer Cell. 2019 Apr 15; 35(4): 573–587.e6. Published online 2019 Apr 8. doi: 10.1016/j.ccell.2019.03.002
PMCID:
PMC10132447
AbstractArticlePDF–1.2M
5.
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells
Xin Wang, Xiaoxiao Wang, Xinbao Zhang, Yan Zhang, Zhenhua Zhu, Yuting Li, Meng Zhang, Junxiang Ji, Yang Yu, Shou-Dong Ye
J Biol Chem. 2021 Nov; 297(5): 101332. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101332
PMCID:
PMC8577099
AbstractArticlePDF–6.0M
6.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
7.
Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó
Cell Rep. Author manuscript; available in PMC 2021 Mar 17.
Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729
PMCID:
PMC7968144
AbstractArticlePDF–1.7M
8.
MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells
Mary P LaPierre, Svenja Godbersen, Mònica Torres Esteban, Anaïs Nura Schad, Mathias Treier, Umesh Ghoshdastider, Markus Stoffel
Endocrinology. 2021 Feb; 162(2): bqaa220. Published online 2020 Nov 28. doi: 10.1210/endocr/bqaa220
PMCID:
PMC7774778
AbstractArticle
9.
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas
Laura Esteban-Burgos, Haiyun Wang, Patricia Nieto, Jie Zheng, Carmen Blanco-Aparicio, Carmen Varela, Gonzalo Gómez-López, Fernando Fernández-García, Manuel Sanclemente, Carmen Guerra, Matthias Drosten, Javier Galán, Eduardo Caleiras, Jorge Martínez-Torrecuadrada, Lluis Fajas, Sheng-Bin Peng, David Santamaría, Monica Musteanu, Mariano Barbacid
Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24415–24426. Published online 2020 Sep 10. doi: 10.1073/pnas.2002520117
PMCID:
PMC7533841
AbstractArticlePDF–2.0M
10.
A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations
Yoshiro Niitsu, Yasushi Sato, Kunihiro Takanashi, Tsuyoshi Hayashi, Naoko Kubo-Birukawa, Fumiko Shimizu, Naoki Fujitani, Rai Shimoyama, Takehiro Kukitsu, Wataru Kurata, Yasuyuki Tashiro, Irving Listowsky
Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19435–19445. Published online 2020 Jul 27. doi: 10.1073/pnas.2000361117
PMCID:
PMC7430992
AbstractArticlePDF–1.9M
11.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
12.
p21 Ras and Phosphatidylinositol-3 Kinase Are Required for Survival of Wild-Type and NF1 Mutant Sensory Neurons
Laura J. Klesse, Luis F. Parada
J Neurosci. 1998 Dec 15; 18(24): 10420–10428. doi: 10.1523/JNEUROSCI.18-24-10420.1998
PMCID:
PMC6793354
AbstractArticlePDF–677K
13.
Raf Kinase Inhibitory Protein is Required for Cerebellar Long-Term Synaptic Depression by Mediating PKC-Dependent MAPK Activation
Yukio Yamamoto, Dongwon Lee, Yoonhee Kim, Bokyoung Lee, Changwoo Seo, Hiroshi Kawasaki, Shinya Kuroda, Keiko Tanaka-Yamamoto
J Neurosci. 2012 Oct 10; 32(41): 14254–14264. doi: 10.1523/JNEUROSCI.2812-12.2012
PMCID:
PMC6622382
AbstractArticlePDF–3.7M
14.
The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning
Michael C. Holter, Lauren. T. Hewitt, Stephanie V. Koebele, Jessica M. Judd, Lei Xing, Heather A. Bimonte-Nelson, Cheryl D. Conrad, Toshiyuki Araki, Benjamin G. Neel, William D. Snider, Jason M. Newbern
PLoS Genet. 2019 Apr; 15(4): e1008108. Published online 2019 Apr 24. doi: 10.1371/journal.pgen.1008108
PMCID:
PMC6502435
AbstractArticlePDF–8.7M
15.
Inhibition of Raf1 ameliorates bleomycin-induced pulmonary fibrosis through attenuation of TGF-β1 signaling
Shuang Li, Jia Liu, Jiangning Tan, Lian Li, Mary J. Kaltreider, Jing Zhao, Daniel J. Kass, Dong Shang, Yutong Zhao
Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1; 315(2): L241–L247. Published online 2018 May 3. doi: 10.1152/ajplung.00093.2018
PMCID:
PMC6139655
AbstractArticle
16.
Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43
Chen Yuan Kam, Adi D. Dubash, Elisa Magistrati, Simona Polo, Karla J.F. Satchell, Farah Sheikh, Paul D. Lampe, Kathleen J. Green
J Cell Biol. 2018 Sep 3; 217(9): 3219–3235. doi: 10.1083/jcb.201710161
PMCID:
PMC6123000
AbstractArticlePDF–3.0M
17.
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway
Bhanu Kanth Manne, Patrick Münzer, Rachit Badolia, Britta Walker-Allgaier, Robert A Campbell, Elizabeth Middleton, Andrew S Weyrich, Satya P Kunapuli, Oliver Borst, Matthew T. Rondina
J Thromb Haemost. Author manuscript; available in PMC 2019 Jun 1.
Published in final edited form as: J Thromb Haemost. 2018 Jun; 16(6): 1211–1225. Published online 2018 May 8. doi: 10.1111/jth.14005
PMCID:
PMC5984143
AbstractArticlePDF–1.0M
18.
Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF
Verena Pfeiffer, Rudolf Götz, Guadelupe Camarero, Helmut Heinsen, Robert Blum, Ulf Rüdiger Rapp
PLoS One. 2018; 13(3): e0192067. Published online 2018 Mar 28. doi: 10.1371/journal.pone.0192067
PMCID:
PMC5873938
AbstractArticlePDF–34M
19.
Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
Jiani C. Yin, Mathew J. Platt, Xixi Tian, Xue Wu, Peter H. Backx, Jeremy A. Simpson, Toshiyuki Araki, Benjamin G. Neel
Nat Commun. 2017; 8: 15518. Published online 2017 May 26. doi: 10.1038/ncomms15518
PMCID:
PMC5458545
AbstractArticlePDF–2.1M
20.
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
Tim Wang, Haiyan Yu, Nicholas W. Hughes, Bingxu Liu, Arek Kendirli, Klara Klein, Walter W. Chen, Eric S. Lander, David M. Sabatini
Cell. Author manuscript; available in PMC 2018 Feb 23.
Published in final edited form as: Cell. 2017 Feb 23; 168(5): 890–903.e15. Published online 2017 Feb 2. doi: 10.1016/j.cell.2017.01.013
PMCID:
PMC5445660
AbstractArticlePDF–2.2M

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