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Items: 1 to 20 of 159

1.
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells
Yu Liu, Yinyan Yu, Suguang Yang, Bin Zeng, Zhuohan Zhang, Guohui Jiao, Yuan Zhang, Limin Cai, Rongcun Yang
Cancer Immunol Immunother. 2009 May; 58(5): 687–697. Published online 2008 Oct 1. doi: 10.1007/s00262-008-0591-5
PMCID:
PMC11030939
AbstractArticlePDF–581K
2.
PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice
Elselien Frijlink, Douwe M.T. Bosma, Julia Busselaar, Thomas W. Battaglia, Mo D. Staal, Inge Verbrugge, Jannie Borst
J Clin Invest. 2024 Mar 15; 134(6): e171154. Published online 2024 Feb 13. doi: 10.1172/JCI171154
PMCID:
PMC10940086
AbstractArticlePDF–8.0M
3.
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency
Cynthia Turnbull, Josiah Bones, Maurice Stanley, Arti Medhavy, Hao Wang, Ayla May D. Lorenzo, Jean Cappello, Somasundhari Shanmuganandam, Abhimanu Pandey, Sandali Seneviratne, Grant J Brown, Xiangpeng Meng, David Fulcher, Gaetan Burgio, Si Ming Man, Carmen de Lucas Collantes, Mercedes Gasior, Eduardo López Granados, Pilar Martin, Simon H. Jiang, Matthew C. Cook, Julia I. Ellyard, Vicki Athanasopoulos, Ben Corry, Pablo F. Canete, Carola G. Vinuesa
Sci Adv. 2023 Dec 8; 9(49): eadi9566. Published online 2023 Dec 6. doi: 10.1126/sciadv.adi9566
PMCID:
PMC10699772
AbstractArticlePDF–1.8M
4.
Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
Christopher Bailey, Yuanyi Wei, Jinsong Yan, Dan Huang, Peng Zhang, Chong Qi, Christopher Lazarski, JuanJuan Su, Fei Tang, Chun-shu Wong, Pan Zheng, Yan Liu, Yang Liu, Yin Wang
Cell Rep Med. 2023 Nov 21; 4(11): 101236. Published online 2023 Oct 11. doi: 10.1016/j.xcrm.2023.101236
PMCID:
PMC10694596
AbstractArticlePDF–8.5M
5.
IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice
Daria Krzikalla, Alena Laschtowitz, Lisa Leypoldt, Cornelia Gottwick, Pia Averhoff, Sören Weidemann, Ansgar W. Lohse, Samuel Huber, Christoph Schramm, Dorothee Schwinge, Johannes Herkel, Antonella Carambia
Cell Mol Gastroenterol Hepatol. 2024; 17(1): 79–91. Published online 2023 Sep 19. doi: 10.1016/j.jcmgh.2023.09.006
PMCID:
PMC10665921
AbstractArticlePDF–3.4M
6.
Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
Mengdi Guo, Diala Abd-Rabbo, Bruna C. Bertol, Madeleine Carew, Sabelo Lukhele, Laura M. Snell, Wenxi Xu, Giselle M. Boukhaled, Heidi Elsaesser, Marie Jo Halaby, Naoto Hirano, Tracy L. McGaha, David G. Brooks
Cell Rep. Author manuscript; available in PMC 2023 Oct 16.
Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113047. Published online 2023 Aug 30. doi: 10.1016/j.celrep.2023.113047
PMCID:
PMC10578141
AbstractArticlePDF–3.5M
7.
CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice
Hiroe Tetsu, Kanako Nakayama, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Sci Rep. 2023; 13: 7936. Published online 2023 May 16. doi: 10.1038/s41598-023-35139-y
Correction in:
Sci Rep. 2023; 13: 10552.
PMCID:
PMC10188484
AbstractArticlePDF–3.0M
8.
T cells specific for α-myosin drive immunotherapy related myocarditis
Margaret L. Axelrod, Wouter C. Meijers, Elles M. Screever, Juan Qin, Mary Grace Carroll, Xiaopeng Sun, Elie Tannous, Yueli Zhang, Ayaka Sugiura, Brandie C. Taylor, Ann Hanna, Shaoyi Zhang, Kaushik Amancherla, Warren Tai, Jordan J. Wright, Spencer C. Wei, Susan R. Opalenik, Abigail L. Toren, Jeffrey C. Rathmell, P. Brent Ferrell, Elizabeth J. Phillips, Simon Mallal, Douglas B. Johnson, James P. Allison, Javid J. Moslehi, Justin M. Balko
Nature. Author manuscript; available in PMC 2023 Nov 16.
Published in final edited form as: Nature. 2022 Nov; 611(7937): 818–826. Published online 2022 Nov 16. doi: 10.1038/s41586-022-05432-3
PMCID:
PMC9930174
AbstractArticlePDF–2.9M
9.
CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
Daniel A. Michelson, Christophe Benoist, Diane Mathis
Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48): e2215474119. Published online 2022 Nov 21. doi: 10.1073/pnas.2215474119
PMCID:
PMC9860321
AbstractArticlePDF–2.9M
10.
Hormonal Therapies Upregulate MANF and Overcome Female Susceptibility to Immune Checkpoint Inhibitor-Myocarditis
Yaohua Zhang, Chengcao Sun, Yajuan Li, Juan Qin, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Zilong Zhao, Andrew Wu, Yutao Xi, Jun Yao, Mien-Chie Hung, George A. Calin, Jie Cheng, Bora Lim, Lorenz H. Lehmann, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang, Javid J. Moslehi, Chunru Lin
Sci Transl Med. Author manuscript; available in PMC 2023 Jan 3.
Published in final edited form as: Sci Transl Med. 2022 Nov 2; 14(669): eabo1981. Published online 2022 Nov 2. doi: 10.1126/scitranslmed.abo1981
PMCID:
PMC9809130
AbstractArticlePDF–4.8M
11.
A Mouse Model of the “LEAP” Study Reveals a Role for CTLA-4 in Preventing Peanut Allergy Induced by Environmental Peanut Exposure
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
J Allergy Clin Immunol. Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2022 Aug; 150(2): 425–439.e3. Published online 2022 Mar 12. doi: 10.1016/j.jaci.2022.02.024
PMCID:
PMC9378358
AbstractArticlePDF–2.1M
12.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Francesco Marangoni, Ademi Zhakyp, Michela Corsini, Shannon N. Geels, Esteban Carrizosa, Martin Thelen, Vinidhra Mani, Jasper N. Prüßmann, Ross D. Warner, Aleksandra J. Ozga, Mauro Di Pilato, Shivashankar Othy, Thorsten R. Mempel
Cell. Author manuscript; available in PMC 2022 Jul 22.
Published in final edited form as: Cell. 2021 Jul 22; 184(15): 3998–4015.e19. Published online 2021 Jun 21. doi: 10.1016/j.cell.2021.05.027
PMCID:
PMC8664158
AbstractArticlePDF–2.6M
13.
Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation
Harry H. Matundan, Ujjaldeep Jaggi, Jack Yu, Omid Akbari, Homayon Ghiasi
mBio. 2021 Jul-Aug; 12(4): e01176-21. Published online 2021 Jul 20. doi: 10.1128/mBio.01176-21
PMCID:
PMC8406230
AbstractArticlePDF–3.5M
14.
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumors
Roberta Zappasodi, Inna Serganova, Ivan J. Cohen, Masatomo Maeda, Masahiro Shindo, Yasin Senbabaoglu, McLane J. Watson, Avigdor Leftin, Rachana Maniyar, Svena Verma, Matthew Lubin, Myat Ko, Mayuresh M. Mane, Hong Zhong, Cailian Liu, Arnab Ghosh, Mohsen Abu-Akeel, Ellen Ackerstaff, Jason A. Koutcher, Ping-Chih Ho, Greg M. Delgoffe, Ronald Blasberg, Jedd D. Wolchok, Taha Merghoub
Nature. Author manuscript; available in PMC 2021 Aug 15.
Published in final edited form as: Nature. 2021 Mar; 591(7851): 652–658. Published online 2021 Feb 15. doi: 10.1038/s41586-021-03326-4
PMCID:
PMC8057670
AbstractArticlePDF–6.3M
15.
A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention
Spencer C. Wei, Wouter C. Meijers, Margaret L. Axelrod, Nana-Ama A.S. Anang, Elles M. Screever, Elizabeth C. Wescott, Douglas B. Johnson, Elizabeth Whitley, Lorenz Lehmann, Pierre-Yves Courand, James J. Mancuso, Lauren E. Himmel, Benedicte Lebrun-Vignes, Matthew J. Wleklinski, Bjorn C. Knollmann, Jayashree Srinivasan, Yu Li, Oluwatomisin T. Atolagbe, Xiayu Rao, Yang Zhao, Jing Wang, Lauren I.R. Ehrlich, Padmanee Sharma, Joe-Elie Salem, Justin M. Balko, Javid J. Moslehi, James P. Allison
Cancer Discov. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Cancer Discov. 2021 Mar; 11(3): 614–625. Published online 2020 Nov 30. doi: 10.1158/2159-8290.CD-20-0856
PMCID:
PMC8041233
AbstractArticlePDF–1.9M
16.
CTLA-4 expression by B-1a B cells is essential for immune tolerance
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V. Youngyunpipatkul, James B. Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G. Vilches-Moure, Denong Wang, Michael P. Snyder, Ji-Yang Wang, Jian Han, Leonore A. Herzenberg
Nat Commun. 2021; 12: 525. Published online 2021 Jan 22. doi: 10.1038/s41467-020-20874-x
PMCID:
PMC7822855
AbstractArticlePDF–6.5M
17.
The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription
Jing Guo, Zhonghui Xue, Ruoyu Ma, Weiwei Yi, Zhaoyuan Hui, Yixin Guo, Yuxi Yao, Wenqiang Cao, Jianli Wang, Zhenyu Ju, Linrong Lu, Lie Wang
Cell Mol Immunol. 2020 Dec; 17(12): 1222–1232. Published online 2019 Sep 11. doi: 10.1038/s41423-019-0289-y
PMCID:
PMC7784856
AbstractArticlePDF–3.0M
18.
Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4-dependent and T follicular helper cell-specific
G. Michael La Muraglia, II, Susan Zeng, Emma S. Crichton, Maylene E. Wagener, Mandy L. Ford, I. Raul Badell
Am J Transplant. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Am J Transplant. 2021 Jan; 21(1): 73–86. Published online 2020 Jun 11. doi: 10.1111/ajt.16004
PMCID:
PMC7665991
AbstractArticlePDF–2.0M
19.
Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice
Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens
Cells. 2020 Sep; 9(9): 1987. Published online 2020 Aug 29. doi: 10.3390/cells9091987
PMCID:
PMC7565685
AbstractArticlePDF–1.5M
20.
TIM3 comes of age as an inhibitory receptor
Yochai Wolf, Ana C. Anderson, Vijay K. Kuchroo
Nat Rev Immunol. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Nat Rev Immunol. 2020 Mar; 20(3): 173–185. Published online 2019 Nov 1. doi: 10.1038/s41577-019-0224-6
PMCID:
PMC7327798
AbstractArticlePDF–1.1M

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