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Items: 1 to 20 of 71

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2
Sophie Broadway-Stringer, He Jiang, Kirsty Wadmore, Charlotte Hooper, Gillian Douglas, Violetta Steeples, Amar J. Azad, Evie Singer, Jasmeet S. Reyat, Frantisek Galatik, Elisabeth Ehler, Pauline Bennett, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Benjamin Davies, Kristina Djinovic-Carugo, Mathias Gautel, Hugh Watkins, Katja Gehmlich
Cells. 2023 Mar; 12(5): 721. Published online 2023 Feb 24. doi: 10.3390/cells12050721
PMCID:
PMC10001372
AbstractArticlePDF–2.7M
3.
DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
Chiyeol Choi, Hyerin Kim, Jiyoung Oh, Chanho Park, Min Kim, Chu-Sook Kim, Jiyoung Park
Life Sci Alliance. 2023 Feb; 6(2): e202201556. Published online 2022 Nov 30. doi: 10.26508/lsa.202201556
PMCID:
PMC9713304
AbstractArticlePDF–2.3M
4.
Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK/Mff signaling pathway
Jing-Jie Xiao, Qing Liu, Ying Li, Fang-Fang Peng, Shan Wang, Zhihan Zhang, Hui Liu, Hong Yu, Shengxiang Tao, Bai-Fang Zhang
Cell Death Dis. 2022 Sep; 13(9): 774. Published online 2022 Sep 7. doi: 10.1038/s41419-022-05220-x
PMCID:
PMC9452577
AbstractArticlePDF–8.3M
5.
Upregulation of RCAN1.4 by HIF1α alleviates OGD‐induced inflammatory response in astrocytes
Xiaxin Yang, Yan Yun, Pin Wang, Juan Zhao, Xiulian Sun
Ann Clin Transl Neurol. 2022 Aug; 9(8): 1224–1240. Published online 2022 Jul 14. doi: 10.1002/acn3.51624
PMCID:
PMC9380140
AbstractArticlePDF–4.5M
6.
Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells
Chen Chen, Pengfei Cui, Kevin Zhao, Gengming Niu, Shiqiang Hou, Dezheng Zhao, Huiyan Zeng
Microvasc Res. Author manuscript; available in PMC 2023 Mar 1.
Published in final edited form as: Microvasc Res. 2022 Mar; 140: 104305. Published online 2021 Dec 24. doi: 10.1016/j.mvr.2021.104305
PMCID:
PMC9295909
AbstractArticlePDF–1.6M
7.
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer’s disease, and normative aging
Helen Wong, Jordan M. Buck, Curtis Borski, Jessica T. Pafford, Bailey N. Keller, Ryan A. Milstead, Jessica L. Hanson, Jerry A. Stitzel, Charles A. Hoeffer
J Neurodev Disord. 2022; 14: 33. Published online 2022 May 24. doi: 10.1186/s11689-022-09444-y
PMCID:
PMC9128232
AbstractArticlePDF–12M
8.
Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background
Masashi Muramatsu, Tsuyoshi Osawa, Yuri Miyamura, Suguru Nakagawa, Toshiya Tanaka, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai, Sandra Ryeom, Takashi Minami
J Biol Chem. 2021 Jan-Jun; 296: 100697. Published online 2021 Apr 23. doi: 10.1016/j.jbc.2021.100697
PMCID:
PMC8142255
AbstractArticlePDF–4.9M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression
Wang Shuo, Haicong Li, Nishijo Muneko, Nishino Yoshikazu, Nobuo Kato, Yuji Kasamaki, Tadashi Ueda, Tsugiyasu Kanda
J Int Med Res. 2020 Nov; 48(11): 0300060520964016. Published online 2020 Nov 29. doi: 10.1177/0300060520964016
PMCID:
PMC7708711
AbstractArticlePDF–533K
11.
A Calcineurin-Hoxb13 Axis Regulates Growth Mode of Mammalian Cardiomyocytes
Ngoc Uyen Nhi Nguyen, Diana Canseco, Feng Xiao, Yuji Nakada, Shujuan Li, Nicholas Lam, Shalini A. Muralidhar, Jainy Savla, Joseph A. Hill, Victor Le, Kareem A. Zidan, Hamed W. El-Feky, Zhaoning Wang, Mahmoud Salama Ahmed, Maimon Hubbi, Ivan Menendez-Montes, Jesung Moon, Shah R. Ali, Victoria Le, Elisa Villalobos, Magid S. Mohamed, Waleed M. Elhelaly, Suwannee Thet, Chukwuemeka George Anene-Nzelu, Wilson Lek Wen Tan, Roger Foo, Xun Meng, Mohammed Kanchwala, Chao Xing, Jagoree Roy, Martha S. Cyert, Beverly A. Rothermel, Hesham A. Sadek
Nature. Author manuscript; available in PMC 2020 Nov 17.
Published in final edited form as: Nature. 2020 Jun; 582(7811): 271–276. Published online 2020 Apr 22. doi: 10.1038/s41586-020-2228-6
PMCID:
PMC7670845
AbstractArticlePDF–6.5M
12.
Neuronal activity regulates alternative exon usage
Johanna Denkena, Andrea Zaisser, Barbara Merz, Bertram Klinger, Dietmar Kuhl, Nils Blüthgen, Guido Hermey
Mol Brain. 2020; 13: 148. Published online 2020 Nov 10. doi: 10.1186/s13041-020-00685-3
PMCID:
PMC7656758
AbstractArticlePDF–3.9M
13.
Down Syndrome Critical Region 1 Reduces Oxidative Stress–Induced Retinal Ganglion Cells Apoptosis via CREB–Bcl-2 Pathway
Yuxun Shi, Dan Ye, Rong Huang, Yue Xu, Peng Lu, Hailiu Chen, Jingjing Huang
Invest Ophthalmol Vis Sci. 2020 Oct; 61(12): 23. Published online 2020 Oct 26. doi: 10.1167/iovs.61.12.23
PMCID:
PMC7594594
AbstractArticlePDF–5.2M
14.
Loss of Down syndrome critical region-1 mediated hypercholesterolemia accelerates corneal opacity via pathological neo-vessel formation
Masashi Muramatsu, Suguru Nakagawa, Tsuyoshi Osawa, Tetsuya Toyono, Akiyoshi Uemura, Hiroyasu Kidoya, Nobuyuki Takakura, Tomohiko Usui, Sandra Ryeom, Takashi Minami
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Oct; 40(10): 2425–2439. Published online 2020 Aug 13. doi: 10.1161/ATVBAHA.120.315003
PMCID:
PMC7518298
AbstractArticlePDF–1001K
15.
The Down Syndrome Critical Region Protein RCAN1 Regulates Long-Term Potentiation and Memory via Inhibition of Phosphatase Signaling
Charles A. Hoeffer, Asim Dey, Nita Sachan, Helen Wong, Richard J. Patterson, John M. Shelton, James A. Richardson, Eric Klann, Beverly A. Rothermel
J Neurosci. 2007 Nov 28; 27(48): 13161–13172. doi: 10.1523/JNEUROSCI.3974-07.2007
PMCID:
PMC6673398
AbstractArticlePDF–838K
16.
Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling
Xue-yin Pan, Hong-mei You, Ling Wang, Yi-hui Bi, Yang Yang, Hong-wu Meng, Xiao-ming Meng, Tao-tao Ma, Cheng Huang, Jun Li
Theranostics. 2019; 9(15): 4308–4323. Published online 2019 Jun 9. doi: 10.7150/thno.32710
PMCID:
PMC6599664
AbstractArticlePDF–3.2M
17.
DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA
Ji-Young Seo, Youngseob Jung, Do-Yeon Kim, Hye Guk Ryu, Juhyun Lee, Sung Wook Kim, Kyong-Tai Kim
Cell Death Dis. 2019 Feb; 10(2): 49. Published online 2019 Jan 18. doi: 10.1038/s41419-018-1299-x
PMCID:
PMC6362140
AbstractArticlePDF–2.1M
18.
Regulator of Calcineurin 1 helps coordinate whole‐body metabolism and thermogenesis
David Rotter, Heshan Peiris, D Bennett Grinsfelder, Alyce M Martin, Jana Burchfield, Valentina Parra, Christi Hull, Cyndi R Morales, Claire F Jessup, Dusan Matusica, Brian W Parks, Aldons J Lusis, Ngoc Uyen Nhi Nguyen, Misook Oh, Israel Iyoke, Tanvi Jakkampudi, D Randy McMillan, Hesham A Sadek, Matthew J Watt, Rana K Gupta, Melanie A Pritchard, Damien J Keating, Beverly A Rothermel
EMBO Rep. 2018 Dec; 19(12): e44706. Published online 2018 Nov 2. doi: 10.15252/embr.201744706
PMCID:
PMC6280800
AbstractArticlePDF–2.0M
19.
Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Silvia Villahoz, Paula Sofía Yunes-Leites, Nerea Méndez-Barbero, Katia Urso, Elena Bonzon-Kulichenko, Sagrario Ortega, J. Francisco Nistal, Jesus Vazquez, Stefan Offermanns, Juan Miguel Redondo, Miguel R. Campanero
Nat Commun. 2018; 9: 4795. Published online 2018 Nov 15. doi: 10.1038/s41467-018-07071-7
PMCID:
PMC6237779
AbstractArticlePDF–3.8M
20.
Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome
Samantha D McElyea, John M Starbuck, Danika M Tumbleson-Brink, Emily Harrington, Joshua D Blazek, Ahmed Ghoneima, Katherine Kula, Randall J Roper
Hum Mol Genet. 2016 Nov 15; 25(22): 4856–4869. Published online 2016 Sep 5. doi: 10.1093/hmg/ddw309
PMCID:
PMC6049609
AbstractArticlePDF–558K

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