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Select item 104717041.

Targeted inhibition of eIF5A^hpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer

Jincheng Zeng, Ziyu Ye, Shihong Shi, Yanfang Liang, Qingyu Meng, Qunzhou Zhang, Anh D. Le

Cell Death Dis. 2023 Aug; 14(8): 579. Published online 2023 Aug 31. doi: 10.1038/s41419-023-06109-z

PMCID:: PMC10471704

Abstract Article PDF–7.7M

Select item 102757252.

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis

Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci

HGG Adv. 2023 Jul 13; 4(3): 100206. Published online 2023 May 18. doi: 10.1016/j.xhgg.2023.100206

PMCID:: PMC10275725

Abstract Article PDF–3.6M

Select item 100848583.

New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

Chad R. Schultz, Ryan D. Sheldon, Huirong Xie, Elena Y. Demireva, Katie L. Uhl, Dalen W. Agnew, Dirk Geerts, André S. Bachmann

Biol Open. 2023 Mar 15; 12(3): bio059647. Published online 2023 Mar 21. doi: 10.1242/bio.059647

PMCID:: PMC10084858

Abstract Article PDF–3.8M

Select item 94819334.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 86052485.

Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice

Rajesh Kumar Kar, Ashleigh S. Hanner, Matthew F. Starost, Danielle Springer, Teresa L. Mastracci, Raghavendra G. Mirmira, Myung Hee Park

J Biol Chem. 2021 Nov; 297(5): 101333. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101333

PMCID:: PMC8605248

Abstract Article PDF–3.6M

Select item 82666176.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 80344187.

Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development

Leah R. Padgett, Morgan A. Robertson, Emily K. Anderson‐Baucum, Craig T. Connors, Wenting Wu, Raghavendra G. Mirmira, Teresa L. Mastracci

FASEB J. 2021 May; 35(5): e21473. Published online 2021 Apr 3. doi: 10.1096/fj.201903177R

PMCID:: PMC8034418

Abstract Article PDF–1.5M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74623049.

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

Dong Ma, Bin Zheng, He-liang Liu, Yong-bo Zhao, Xiao Liu, Xin-hua Zhang, Qiang Li, Wei-bo Shi, Toru Suzuki, Jin-kun Wen

PLoS Biol. 2020 Aug; 18(8): e3000808. Published online 2020 Aug 20. doi: 10.1371/journal.pbio.3000808

PMCID:: PMC7462304

Abstract Article PDF–4.9M

Select item 741599110.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 668882811.

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Daniel J. Puleston, Michael D. Buck, Ramon I. Klein Geltink, Ryan L. Kyle, George Caputa, David O’Sullivan, Alanna M. Cameron, Angela Castoldi, Yaarub Musa, Agnieszka M. Kabat, Ying Zhang, Lea J. Flachsmann, Cameron S. Field, Annette E. Patterson, Stefanie Scherer, Francesca Alfei, Francesc Baixauli, S. Kyle Austin, Beth Kelly, Mai Matsushita, Jonathan D. Curtis, Katarzyna M. Grzes, Matteo Villa, Mauro Corrado, David E. Sanin, Jing Qiu, Nora Pällman, Katelyn Paz, Maria Elena Maccari, Bruce R. Blazar, Gerhard Mittler, Joerg M. Buescher, Dietmar Zehn, Sabine Rospert, Edward J. Pearce, Stefan Balabanov, Erika L. Pearce

Cell Metab. 2019 Aug 6; 30(2): 352–363.e8. doi: 10.1016/j.cmet.2019.05.003

PMCID:: PMC6688828

Abstract Article PDF–4.1M

Select item 634668512.

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells

Farzad Asadi, Savita Dhanvantari

Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792

PMCID:: PMC6346685

Abstract Article PDF–3.6M

Select item 633346013.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 626277714.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 624418315.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 451309616.

Biological Relevance and Therapeutic Potential of the Hypusine Modification System

Nora Pällmann, Melanie Braig, Henning Sievert, Michael Preukschas, Irm Hermans-Borgmeyer, Michaela Schweizer, Claus Henning Nagel, Melanie Neumann, Peter Wild, Eugenia Haralambieva, Christian Hagel, Carsten Bokemeyer, Joachim Hauber, Stefan Balabanov

J Biol Chem. 2015 Jul 24; 290(30): 18343–18360. Published online 2015 Jun 2. doi: 10.1074/jbc.M115.664490

PMCID:: PMC4513096

Abstract Article PDF–4.7M

Select item 407349417.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 395920918.

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress

Liyong Zhang, Xin Chen, Parveen Sharma, Mark Moon, Alex D. Sheftel, Fayez Dawood, Mai P. Nghiem, Jun Wu, Ren-Ke Li, Anthony O. Gramolini, Poul H. Sorensen, Josef M. Penninger, John H. Brumell, Peter P. Liu

Nat Commun. 2014 Mar 11; 5: 3430. Published online 2014 Mar 11. doi: 10.1038/ncomms4430

PMCID:: PMC3959209

Abstract Article PDF–3.6M

Select item 390295419.

Evaluation of TRAP-sequencing technology with a versatile conditional mouse model

Mike Hupe, Minerva Xueting Li, Karin Gertow Gillner, Ralf H. Adams, Jan M. Stenman

Nucleic Acids Res. 2014 Jan; 42(2): e14. Published online 2013 Oct 26. doi: 10.1093/nar/gkt995

PMCID:: PMC3902954

Abstract Article PDF–18M

Select item 373458120.

Phosphoinositide-specific Phospholipase C β 1b (PI-PLCβ1b) Interactome: Affinity Purification-Mass Spectrometry Analysis of PI-PLCβ1b with Nuclear Protein

Manuela Piazzi, William L. Blalock, Alberto Bavelloni, Irene Faenza, Antonietta D'Angelo, Nadir M. Maraldi, Lucio Cocco

Mol Cell Proteomics. 2013 Aug; 12(8): 2220–2235. Published online 2013 May 9. doi: 10.1074/mcp.M113.029686

PMCID:: PMC3734581

Abstract Article PDF–1.9M

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