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Select item 112828591.

MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1

Xiao Li, Kai Cheng, Meng-Di Shang, Yong Yang, Bin Hu, Xi Wang, Xiao-Dan Wei, Yan-Chun Han, Xiao-Gang Zhang, Meng-Hua Dong, Zhen-Lin Yang, Jiu-Qiang Wang

BMC Cancer. 2024; 24: 902. Published online 2024 Jul 26. doi: 10.1186/s12885-024-12667-y

PMCID:: PMC11282859

Abstract Article PDF–3.9M

Select item 112168662.

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Bhaskar Saha, Hallvard Olsvik, Geneva L Williams, Seeun Oh, Gry Evjen, Eva Sjøttem, Michael A Mandell

Cell Rep. Author manuscript; available in PMC 2024 Jul 2.

Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114294. Published online 2024 May 29. doi: 10.1016/j.celrep.2024.114294

PMCID:: PMC11216866

Abstract Article PDF–3.2M

Select item 112094743.

cGAS-STING-TBK1 Signaling Promotes Valproic Acid-Responsive Human Cytomegalovirus Immediate-Early Transcription during Infection of Incompletely Differentiated Myeloid Cells

Emily R. Albright, Robert F. Kalejta

Viruses. 2024 Jun; 16(6): 877. Published online 2024 May 30. doi: 10.3390/v16060877

PMCID:: PMC11209474

Abstract Article PDF–2.7M

Select item 111708944.

Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations

Haitian Nan, Yeon-Jeong Kim, Min Chu, Dan Li, Jieying Li, Deming Jiang, Yiming Wu, Toshihisa Ohtsuka, Liyong Wu

Alzheimers Res Ther. 2024; 16: 127. Published online 2024 Jun 13. doi: 10.1186/s13195-024-01493-w

PMCID:: PMC11170894

Abstract Article PDF–3.8M

Select item 111648965.

Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1

Elisabeth Bankell, Li Liu, Jennifer van der Horst, Catarina Rippe, Thomas A. Jepps, Bengt-Olof Nilsson, Karl Swärd

Sci Rep. 2024; 14: 13321. Published online 2024 Jun 10. doi: 10.1038/s41598-024-63901-3

PMCID:: PMC11164896

Abstract Article PDF–7.1M

Select item 111481846.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094837.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 110503678.

TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22

Liang Liu, Mitsuyo Matsumoto, Miki Watanabe-Matsui, Tadashi Nakagawa, Yuko Nagasawa, Jingyao Pang, Bert K. K. Callens, Akihiko Muto, Kyoko Ochiai, Hirotaka Takekawa, Mahabub Alam, Hironari Nishizawa, Mikako Shirouzu, Hiroki Shima, Keiko Nakayama, Kazuhiko Igarashi

Int J Mol Sci. 2024 Apr; 25(8): 4141. Published online 2024 Apr 9. doi: 10.3390/ijms25084141

PMCID:: PMC11050367

Abstract Article PDF–2.4M

Select item 110227039.

Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC

Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu

Adv Sci (Weinh) 2024 Apr; 11(15): 2305541. Published online 2024 Feb 13. doi: 10.1002/advs.202305541

PMCID:: PMC11022703

Abstract Article PDF–6.6M

Select item 1095972410.

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice

David Brenner, Kirsten Sieverding, Jahnavi Srinidhi, Susanne Zellner, Christopher Secker, Rüstem Yilmaz, Julia Dyckow, Shady Amr, Anna Ponomarenko, Esra Tunaboylu, Yasmin Douahem, Joana S. Schlag, Lucía Rodríguez Martínez, Georg Kislinger, Cornelia Niemann, Karsten Nalbach, Wolfgang P. Ruf, Jonathan Uhl, Johanna Hollenbeck, Lucas Schirmer, Alberto Catanese, Christian S. Lobsiger, Karin M. Danzer, Deniz Yilmazer-Hanke, Christian Münch, Philipp Koch, Axel Freischmidt, Martina Fetting, Christian Behrends, Rosanna Parlato, Jochen H. Weishaupt

J Exp Med. 2024 May 6; 221(5): e20221190. Published online 2024 Mar 22. doi: 10.1084/jem.20221190

PMCID:: PMC10959724

Abstract Article PDF–7.3M

Select item 1093663611.

AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer

Syn Kok Yeo, Michael Haas, Kanakaraju Manupati, Mingang Hao, Fuchun Yang, Song Chen, Jun-Lin Guan

Autophagy. 2024; 20(3): 525–540. Published online 2023 Sep 21. doi: 10.1080/15548627.2023.2259775

PMCID:: PMC10936636

Abstract Article PDF–8.4M

Select item 1093326712.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 1090772413.

Optineurin provides a mitophagy contact site for TBK1 activation

Koji Yamano, Momoha Sawada, Reika Kikuchi, Kafu Nagataki, Waka Kojima, Ryu Endo, Hiroki Kinefuchi, Atsushi Sugihara, Tomoshige Fujino, Aiko Watanabe, Keiji Tanaka, Gosuke Hayashi, Hiroshi Murakami, Noriyuki Matsuda

EMBO J. 2024 Mar; 43(5): 754–779. Published online 2024 Jan 29. doi: 10.1038/s44318-024-00036-1

PMCID:: PMC10907724

Abstract Article PDF–10M

Select item 1070236614.

NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis

Swagatika Paul, Shireen A. Sarraf, Ki Hong Nam, Leila Zavar, Nicole DeFoor, Sahitya Ranjan Biswas, Lauren E. Fritsch, Tomer M. Yaron, Jared L. Johnson, Emily M. Huntsman, Lewis C. Cantley, Alban Ordureau, Alicia M. Pickrell

J Cell Biol. 2024 Feb 5; 223(2): e202303082. Published online 2023 Dec 7. doi: 10.1083/jcb.202303082

PMCID:: PMC10702366

Abstract Article PDF–8.5M

Select item 1056587615.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644