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Select item 113884611.

Is There a Functional Role for the Knotted Topology in Protein UCH-L1?

Sara G. F. Ferreira, Manoj K. Sriramoju, Shang-Te Danny Hsu, Patrícia F. N. Faísca, Miguel Machuqueiro

J Chem Inf Model. 2024 Sep 9; 64(17): 6827–6837. Published online 2024 Jul 24. doi: 10.1021/acs.jcim.4c00880

PMCID:: PMC11388461

Abstract Article PDF–3.7M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111481844.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 109902775.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 109332676.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108975217.

UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas

Shiqin Liu, Timothy Chai, Fernando Garcia-Marques, Qingqing Yin, En-Chi Hsu, Michelle Shen, Angus Martin Shaw Toland, Abel Bermudez, Alifiani B. Hartono, Christopher F. Massey, Chung S. Lee, Liwei Zheng, Maya Baron, Caden J. Denning, Merve Aslan, Holly M. Nguyen, Rosalie Nolley, Amina Zoubeidi, Millie Das, Christian A. Kunder, Brooke E. Howitt, H. Tom Soh, Irving L. Weissman, Michael A. Liss, Arnold I. Chin, James D. Brooks, Eva Corey, Sharon J. Pitteri, Jiaoti Huang, Tanya Stoyanova

Cell Rep Med. 2024 Feb 20; 5(2): 101381. Published online 2024 Jan 19. doi: 10.1016/j.xcrm.2023.101381

PMCID:: PMC10897521

Abstract Article PDF–7.7M

Select item 108164768.

Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson’s Disease

Olga Buneeva, Alexei Medvedev

Int J Mol Sci. 2024 Jan; 25(2): 1303. Published online 2024 Jan 21. doi: 10.3390/ijms25021303

PMCID:: PMC10816476

Abstract Article PDF–664K

Select item 108036359.

Elevated Cerebrospinal Fluid Ubiquitin C-terminal Hydrolase-L1 Levels Correlate with Phenotypic Severity and Therapeutic Response in Niemann-Pick Disease, type C1

Niamh X. Cawley, Spencer Giddens, Nicole M. Farhat, Rachel A. Luke, Katelin E. J. Scott, Hibaaq O. Mohamed, An Dang Do, Elizabeth Berry-Kravis, Stephanie M. Cologna, Fang Liu, Forbes D. Porter

Mol Genet Metab. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: Mol Genet Metab. 2023 Nov; 140(3): 107656. Published online 2023 Jul 23. doi: 10.1016/j.ymgme.2023.107656

PMCID:: PMC10803635

Abstract Article PDF–557K

Select item 1059973210.

UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells

Yuhui Zheng, Dongliang Shi, Linlin Chen, Yinghong Yang, Meihong Yao

Aging (Albany NY) 2023 Oct 15; 15(19): 10593–10606. Published online 2023 Oct 9. doi: 10.18632/aging.205097

PMCID:: PMC10599732

Abstract Article PDF–1.6M

Select item 1038250511.

UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

Lu Ding, Weiwei Chu, Yu Xia, Ming Shi, Tian Li, Feng-Quan Zhou, David Y. B. Deng

Cell Death Dis. 2023 Jul; 14(7): 479. Published online 2023 Jul 28. doi: 10.1038/s41419-023-06003-8

PMCID:: PMC10382505

Abstract Article PDF–18M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1020218313.

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan

Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091

PMCID:: PMC10202183

Abstract Article PDF–18M

Select item 1017416914.

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2

Joseph S. Bednash, Finny Johns, Daniela Farkas, Ajit Elhance, Jessica Adair, Kirstin Cress, Jacob S. Yount, Adam D. Kenney, James D. Londino, Rama K. Mallampalli

Am J Respir Cell Mol Biol. 2023 May 1; 68(5): 566–576. Published online 2023 Feb 2. doi: 10.1165/rcmb.2022-0331OC

PMCID:: PMC10174169

Abstract Article PDF–1.5M

Select item 1014884315.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 1010202216.

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger

Nat Commun. 2023; 14: 2114. Published online 2023 Apr 13. doi: 10.1038/s41467-023-37836-8