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Items: 1 to 20 of 63

1.
Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle‐aged mouse brains
Zhihui Zhu, Timothy S. McClintock, Erhard Bieberich
Genes Brain Behav. 2024 Aug; 23(4): e12911. Published online 2024 Aug 22. doi: 10.1111/gbb.12911
PMCID:
PMC11339599
AbstractArticlePDF–42M
2.
Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
Yacine Touahri, Joseph Hanna, Nobuhiko Tachibana, Satoshi Okawa, Hedy Liu, Luke Ajay David, Thomas Olender, Lakshmy Vasan, Alissa Pak, Dhruv Nimesh Mehta, Vorapin Chinchalongporn, Anjali Balakrishnan, Robert Cantrup, Rajiv Dixit, Pierre Mattar, Fermisk Saleh, Yaroslav Ilnytskyy, Monzur Murshed, Paul E. Mains, Igor Kovalchuk, Julie L. Lefebvre, Hon S. Leong, Michel Cayouette, Chao Wang, Antonio del Sol, Marjorie Brand, Benjamin E. Reese, Carol Schuurmans
Cell Rep. Author manuscript; available in PMC 2024 Jul 31.
Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114005. Published online 2024 Mar 27. doi: 10.1016/j.celrep.2024.114005
PMCID:
PMC11290456
AbstractArticlePDF–2.2M
3.
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders
Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz
Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700
PMCID:
PMC10769350
AbstractArticlePDF–11M
4.
Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of Ceramides
Qingping Li, Jieyuan Li, Kai Wang, Leyi Liao, Yiyi Li, Hanbiao Liang, Can Huang, Jian Gan, Xiaoyu Dong, Yaowen Hu, Jiaxin Cheng, Hongli Ji, Cuiting Liu, Minghui Zeng, Sheng Yu, Biao Wang, Jianping Qian, Zhongshun Tang, Yonghong Peng, Shanhua Tang, Mengxuan Li, Jie Zhou, Jun Yan, Chuanjiang Li
Cell Mol Gastroenterol Hepatol. 2023; 16(3): 385–410. Published online 2023 May 26. doi: 10.1016/j.jcmgh.2023.05.007
PMCID:
PMC10372907
AbstractArticlePDF–11M
5.
ZFP750 affects the cutaneous barrier through regulating lipid metabolism
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D’Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Sci Adv. 2023 Apr; 9(17): eadg5423. Published online 2023 Apr 28. doi: 10.1126/sciadv.adg5423
PMCID:
PMC10146900
AbstractArticlePDF–2.3M
6.
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x
PMCID:
PMC9938216
AbstractArticlePDF–5.3M
7.
Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy
Anne Montfort, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, Caroline Imbert, Joëlle Riond, Marie Tosolini, Christopher J. Clarke, Florent Dufour, Andrei A. Constantinescu, Nilton De França Junior, Virginie Garcia, Michel Record, Pierre Cordelier, Pierre Brousset, Philippe Rochaix, Sandrine Silvente-Poirot, Nicole Therville, Nathalie Andrieu-Abadie, Thierry Levade, Yusuf A. Hannun, Hervé Benoist, Nicolas Meyer, Olivier Micheau, Céline Colacios, Bruno Ségui
Cancer Immunol Res. Author manuscript; available in PMC 2022 Nov 3.
Published in final edited form as: Cancer Immunol Res. 2021 May; 9(5): 568–582. Published online 2021 Mar 16. doi: 10.1158/2326-6066.CIR-20-0342
PMCID:
PMC9631340
AbstractArticlePDF–1.7M
8.
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
Fabian Schumacher, Alexander Carpinteiro, Michael J. Edwards, Gregory C. Wilson, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Burkhard Kleuser, Katrin Anne Becker, Christian P. Müller, Johannes Kornhuber, Erich Gulbins
J Mol Med (Berl) 2022; 100(10): 1493–1508. Published online 2022 Aug 31. doi: 10.1007/s00109-022-02250-y
PMCID:
PMC9470690
AbstractArticlePDF–1.2M
9.
Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis
Junjun Jing, Jifan Feng, Yuan Yuan, Tingwei Guo, Jie Lei, Fei Pei, Thach-Vu Ho, Yang Chai
Nat Commun. 2022; 13: 4803. Published online 2022 Aug 16. doi: 10.1038/s41467-022-32490-y
PMCID:
PMC9381504
AbstractArticlePDF–6.6M
10.
Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells
Matthieu Lecuyer, Praneeti Pathipati, Joel Faustino, Zinaida S. Vexler
Neurobiol Dis. Author manuscript; available in PMC 2022 May 4.
Published in final edited form as: Neurobiol Dis. 2021 Sep; 157: 105431. Published online 2021 Jun 19. doi: 10.1016/j.nbd.2021.105431
PMCID:
PMC9068249
AbstractArticlePDF–1.2M
11.
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
Liubov S. Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E. Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina Tesch, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J. Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P. Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B. Ekici, Lena M. Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M. Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N. Mitroi, André M. Miranda, Tiago G. Oliveira, Erich Gulbins, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P. Müller
Mol Psychiatry. 2021; 26(12): 7403–7416. Published online 2021 Sep 28. doi: 10.1038/s41380-021-01304-w
PMCID:
PMC8872992
AbstractArticlePDF–3.0M
12.
Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides
Andreas Zietzer, Alina Lisann Jahnel, Marko Bulic, Katharina Gutbrod, Philip Düsing, Mohammed Rabiul Hosen, Peter Dörmann, Nikos Werner, Georg Nickenig, Felix Jansen
Cell Mol Life Sci. 2022 Jan; 79(1): 48. Published online 2021 Dec 24. doi: 10.1007/s00018-021-04049-5
PMCID:
PMC8739297
AbstractArticlePDF–11M
13.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
14.
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis
Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara, Shaofei Zhang, Guangyi Zeng, Chuyu Yun, Yu Yan, Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez, Changtao Jiang
J Clin Invest. 2021 May 3; 131(9): e142865. Published online 2021 May 3. doi: 10.1172/JCI142865
PMCID:
PMC8087211
AbstractArticlePDF–13M
15.
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John
Mol Brain. 2021; 14: 70. Published online 2021 Apr 19. doi: 10.1186/s13041-021-00776-9
Correction in:
Mol Brain. 2021; 14: 108.
PMCID:
PMC8056538
AbstractArticlePDF–1005K
16.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
17.
Inhibition of neutral sphingomyelinase 2 promotes remyelination
Seung-Wan Yoo, Amit Agarwal, Matthew D. Smith, Saja S. Khuder, Emily G. Baxi, Ajit G. Thomas, Camilo Rojas, Mohammed Moniruzzaman, Barbara S. Slusher, Dwight E. Bergles, Peter A. Calabresi, Norman J. Haughey
Sci Adv. 2020 Oct; 6(40): eaba5210. Published online 2020 Oct 2. doi: 10.1126/sciadv.aba5210
PMCID:
PMC7852391
AbstractArticlePDF–10M
18.
Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech
Cell Rep. 2020 Oct 6; 33(1): 108225. Published online 2020 Oct 6. doi: 10.1016/j.celrep.2020.108225
PMCID:
PMC7539531
AbstractArticle
19.
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons
Wenshuo Zhou, Michael Woodson, Michael B. Sherman, Girish Neelakanta, Hameeda Sultana
Emerg Microbes Infect. 2019; 8(1): 307–326. Published online 2019 Mar 1. doi: 10.1080/22221751.2019.1578188
PMCID:
PMC6455149
AbstractArticlePDF–3.1M
20.
Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression
Garthiga Manickam, Pierre Moffatt, Monzur Murshed
Mol Cell Biol. 2019 Feb 15; 39(4): e00370-18. Prepublished online 2018 Dec 10. Published online 2019 Feb 4. doi: 10.1128/MCB.00370-18
PMCID:
PMC6362318
AbstractArticlePDF–4.6M

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