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Select item 109656611.

TIGIT regulates CD4⁺ T cell immunity against polymicrobial sepsis

Xuexin Zhong, Haiping Xie, Shuang Wang, Tingting Ren, Junlin Chen, Yuefang Huang, Niansheng Yang

Front Immunol. 2024; 15: 1290564. Published online 2024 Mar 13. doi: 10.3389/fimmu.2024.1290564

PMCID:: PMC10965661

Abstract Article PDF–15M

Select item 109644792.

TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes

Prerak Trivedi, Gaurang Jhala, David J. De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W. Kay, Helen E. Thomas, Balasubramanian Krishnamurthy

Front Immunol. 2024; 15: 1370907. Published online 2024 Mar 12. doi: 10.3389/fimmu.2024.1370907

PMCID:: PMC10964479

Abstract Article PDF–4.2M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107291314.

Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies

Md Faqrul Hasan, Amanda R Campbell, Tayler J Croom-Perez, Jeremiah L Oyer, Thomas A Dieffenthaller, Liza D Robles-Carrillo, Catherine A Cash, Jonathan E Eloriaga, Sanjana Kumar, Brendan W Andersen, Meisam Naeimi Kararoudi, Brian P Tullius, Dean A Lee, Alicja J Copik

J Immunother Cancer. 2023; 11(12): e007502. Published online 2023 Dec 11. doi: 10.1136/jitc-2023-007502

PMCID:: PMC10729131

Abstract Article PDF–5.2M

Select item 102284075.

Studying TIGIT activity against tumors through the generation of knockout mice

Ahmed Rishiq, Reem Bsoul, Ophir Pick, Ofer Mandelboim

Oncoimmunology. 2023; 12(1): 2217735. Published online 2023 May 29. doi: 10.1080/2162402X.2023.2217735

PMCID:: PMC10228407

Abstract Article PDF–4.2M

Select item 101700766.

Anti-human-TIGIT agonistic antibody ameliorates autoimmune diseases by inhibiting Tfh and Tph cells and enhancing Treg cells

Marenori Kojima, Katsuya Suzuki, Masaru Takeshita, Masaki Ohyagi, Mana Iizuka, Humitsugu Yamane, Keiko Koga, Taku Kouro, Yoshiaki Kassai, Tomoki Yoshihara, Ryutaro Adachi, Kentarou Hashikami, Yuichiro Ota, Keiko Yoshimoto, Yuko Kaneko, Rimpei Morita, Akihiko Yoshimura, Tsutomu Takeuchi

Commun Biol. 2023; 6: 500. Published online 2023 May 9. doi: 10.1038/s42003-023-04874-3

PMCID:: PMC10170076

Abstract Article PDF–2.7M

Select item 100981427.

TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy

Toshiki Yamada, Megumi Tatematsu, Shunsuke Takasuga, Akane Fuchimukai, Kenki Yamagata, Shinsuke Seki, Keiji Kuba, Hideyuki Yoshida, Ichiro Taniuchi, Günter Bernhardt, Kazuko Shibuya, Akira Shibuya, Takechiyo Yamada, Takashi Ebihara

J Exp Med. 2023 Jul 3; 220(7): e20222005. Published online 2023 Apr 10. doi: 10.1084/jem.20222005

PMCID:: PMC10098142

Abstract Article PDF–4.2M

Select item 100227998.

Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis

Yuan Gao, Xiaocheng Zhang, Tingting Jiang, Hao Zhou, Hua Liu, Yuan Hu, Jianping Cao

PLoS Pathog. 2023 Mar; 19(3): e1011242. Published online 2023 Mar 17. doi: 10.1371/journal.ppat.1011242

PMCID:: PMC10022799

Abstract Article PDF–2.9M

Select item 92835749.

TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A–Producing CD4⁺ Tissue-Resident Memory T Cells

Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke, Hui Zhang

Front Immunol. 2022; 13: 931761. Published online 2022 Jul 1. doi: 10.3389/fimmu.2022.931761

PMCID:: PMC9283574

Abstract Article PDF–13M

Select item 851140410.

TIGIT Induces (CD3+) T Cell Dysfunction in Colorectal Cancer by Inhibiting Glucose Metabolism

Qi Shao, Lei Wang, Maoling Yuan, Xiaohong Jin, Zhiming Chen, Changping Wu

Front Immunol. 2021; 12: 688961. Published online 2021 Sep 29. doi: 10.3389/fimmu.2021.688961

PMCID:: PMC8511404

Abstract Article PDF–7.7M

Select item 826227911.

TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy

Wenxiao Zhang, Jerome C. Anyalebechi, Kimberly M. Ramonell, Ching-wen Chen, Jianfeng Xie, Zhe Liang, Deena B. Chihade, Shunsuke Otani, Craig M. Coopersmith, Mandy L. Ford

JCI Insight. 2021 Jun 8; 6(11): e139823. Published online 2021 Jun 8. doi: 10.1172/jci.insight.139823

PMCID:: PMC8262279

Abstract Article PDF–6.1M

Select item 816610512.

DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions

Kazuki Sato, Yumi Yamashita-Kanemaru, Fumie Abe, Rikito Murata, Yuho Nakamura-Shinya, Kazumasa Kanemaru, Masafumi Muratani, André Veillette, Motohito Goto, Mamoru Ito, Akira Shibuya, Kazuko Shibuya

Proc Natl Acad Sci U S A. 2021 May 25; 118(21): e2021309118. Published online 2021 May 19. doi: 10.1073/pnas.2021309118

PMCID:: PMC8166105

Abstract Article PDF–1.9M

Select item 757711813.

Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

Jin-Hwan Han, Mingmei Cai, Jeffery Grein, Samanthi Perera, Hongmei Wang, Mike Bigler, Roenna Ueda, Thomas W. Rosahl, Elaine Pinheiro, Drake LaFace, Wolfgang Seghezzi, Sybil M. Genther Williams

Front Immunol. 2020; 11: 573405. Published online 2020 Oct 7. doi: 10.3389/fimmu.2020.573405

Correction in:: Front Immunol. 2020; 11: 615755.

PMCID:: PMC7577118

Abstract Article PDF–2.5M

Select item 749622014.

Checkpoint Receptor TIGIT Expressed on Tim-1⁺ B Cells Regulates Tissue Inflammation

Sheng Xiao, Lloyd Bod, Nathalie Pochet, Savithri Balasubramanian Kota, Dan Hu, Asaf Madi, Jessica Kilpatrick, Jingwen Shi, Allen Ho, Huiyuan Zhang, Raymond Sobel, Howard L. Weiner, Terry B. Strom, Francisco J. Quintana, Nicole Joller, Vijay K. Kuchroo

Cell Rep. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Cell Rep. 2020 Jul 14; 32(2): 107892. doi: 10.1016/j.celrep.2020.107892

PMCID:: PMC7496220

Abstract Article PDF–2.2M

Select item 722143815.

TIGIT enhances CD4⁺ regulatory T‐cell response and mediates immune suppression in a murine ovarian cancer model

Fengzhen Chen, Yanying Xu, Yulong Chen, Shu Shan

Cancer Med. 2020 May; 9(10): 3584–3591. Published online 2020 Mar 25. doi: 10.1002/cam4.2976

PMCID:: PMC7221438

Abstract Article PDF–1.3M

Select item 706290316.

TIGIT limits immune pathology during viral infections

Michelle Schorer, Nikolas Rakebrandt, Katharina Lambert, Annika Hunziker, Katharina Pallmer, Annette Oxenius, Anja Kipar, Silke Stertz, Nicole Joller

Nat Commun. 2020; 11: 1288. Published online 2020 Mar 9. doi: 10.1038/s41467-020-15025-1

PMCID:: PMC7062903

Abstract Article PDF–1.7M

Select item 644575117.

CD96 is an immune checkpoint that regulates CD8⁺ T-cell antitumor function

Deepak Mittal, Ailin Lepletier, Jason Madore, Amelia Roman Aguilera, Kimberley Stannard, Stephen J. Blake, Vicki L. J. Whitehall, Cheng Liu, Mark L. Bettington, Kazuyoshi Takeda, Georgina V. Long, Richard A. Scolyer, Ruth Lan, Nathan Siemers, Alan Korman, Michele W. L. Teng, Robert Johnston, William C Dougall, Mark J. Smyth

Cancer Immunol Res. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Cancer Immunol Res. 2019 Apr; 7(4): 559–571. Published online 2019 Mar 20. doi: 10.1158/2326-6066.CIR-18-0637

PMCID:: PMC6445751

Abstract Article PDF–2.5M

Select item 633380618.

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice

Lu Zong, Hui Peng, Cheng Sun, Fenglei Li, Meijuan Zheng, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian

Nat Commun. 2019; 10: 221. Published online 2019 Jan 15. doi: 10.1038/s41467-018-08096-8

PMCID:: PMC6333806

Abstract Article PDF–3.9M

Select item 546110519.

TIGIT signalling pathway negatively regulates CD4⁺ T‐cell responses in systemic lupus erythematosus

Lie Mao, Hongyan Hou, Shiji Wu, Yu Zhou, Juan Wang, Jing Yu, Xiaohui Wu, Yanfang Lu, Liyan Mao, Munyemana Jean Bosco, Feng Wang, Ziyong Sun

Immunology. 2017 Jul; 151(3): 280–290. Published online 2017 Feb 20. doi: 10.1111/imm.12715

PMCID:: PMC5461105

Abstract Article PDF–1.1M

Select item 515970620.

DR3 signaling modulates the function of Foxp3⁺ regulatory T cells and the severity of acute graft-versus-host disease

Hidekazu Nishikii, Byung-Su Kim, Yasuhisa Yokoyama, Yan Chen, Jeanette Baker, Antonio Pierini, Maite Alvarez, Melissa Mavers, Kristina Maas-Bauer, Yuqiong Pan, Shigeru Chiba, Robert S. Negrin

Blood. 2016 Dec 15; 128(24): 2846–2858. Prepublished online 2016 Oct 19. doi: 10.1182/blood-2016-06-723783

PMCID:: PMC5159706

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