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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 96585632.

Short-Term Omega-3 Supplementation Modulates Novel Neurovascular and Fatty Acid Metabolic Proteome Changes in the Retina and Ophthalmic Artery of Mice with Targeted Cyp2c44 Gene Deletion

Natarajan Perumal, Anna Herfurth, Norbert Pfeiffer, Caroline Manicam

Cells. 2022 Nov; 11(21): 3494. Published online 2022 Nov 4. doi: 10.3390/cells11213494

PMCID:: PMC9658563

Abstract Article PDF–4.2M

Select item 84556773.

Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery

Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam

Sci Rep. 2021; 11: 18764. Published online 2021 Sep 21. doi: 10.1038/s41598-021-98236-w

PMCID:: PMC8455677

Abstract Article PDF–1.5M

Select item 71914864.

Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation

Sachindra Raj Joshi, Atsushi Kitagawa, Christina Jacob, Ryota Hashimoto, Vidhi Dhagia, Amrit Ramesh, Connie Zheng, Hui Zhang, Allan Jordan, Ian Waddell, Jane Leopold, Cheng-Jun Hu, Ivan F. McMurtry, Angelo D’Alessandro, Kurt R. Stenmark, Sachin A. Gupte

Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1; 318(4): L773–L786. Published online 2020 Mar 11. doi: 10.1152/ajplung.00001.2020

PMCID:: PMC7191486

Abstract Article

Select item 70841205.

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne, Andreas Weigert, Rüdiger Popp, Ingrid Fleming

Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11): 5923–5930. Published online 2020 Mar 2. doi: 10.1073/pnas.1921381117

PMCID:: PMC7084120

Abstract Article PDF–2.0M

Select item 69579276.

Prostaglandins and Other Lipid Mediators (POLM), Special Issue of the 6th European Workshop on Lipid Mediators: Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis

Jiong Hu, Alexandra Geyer, Sarah Dziumbla, Khader Awwad, Darryl C. Zeldin, Wolf-Hagen Schunck, Rüdiger Popp, Timo Frömel, Ingrid Fleming

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: Prostaglandins Other Lipid Mediat. 2017 Nov; 133: 93–102. Published online 2017 Apr 23. doi: 10.1016/j.prostaglandins.2017.04.002

PMCID:: PMC6957927

Abstract Article PDF–2.4M

Select item 59219307.

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans

Mahesha H. Gangadhariah, Blake W. Dieckmann, Louise Lantier, Li Kang, David H. Wasserman, Manuel Chiusa, Charles F. Caskey, Jaime Dickerson, Pengcheng Luo, Jorge L. Gamboa, Jorge H. Capdevila, John D. Imig, Chang Yu, Ambra Pozzi, James M. Luther

Diabetologia. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Diabetologia. 2017 Jun; 60(6): 1066–1075. Published online 2017 Mar 28. doi: 10.1007/s00125-017-4260-0

PMCID:: PMC5921930

Abstract Article PDF–998K

Select item 59078428.

Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma

Meiyi Li, Chen Li, Wei-Xin Liu, Conghui Liu, Jingru Cui, Qingrun Li, Hong Ni, Yingcheng Yang, Chaochao Wu, Chunlei Chen, Xing Zhen, Tao Zeng, Mujun Zhao, Lei Chen, Jiarui Wu, Rong Zeng, Luonan Chen

J Mol Cell Biol. 2017 Dec; 9(6): 489–503. Published online 2017 Jul 14. doi: 10.1093/jmcb/mjx021

PMCID:: PMC5907842

Abstract Article PDF–1.8M

Select item 55829289.

Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension

Ryota Hashimoto, Sachindra Raj Joshi, Houli Jiang, Jorge H. Capdevila, Ivan F. McMurtry, Michal Laniado Schwartzman, Sachin A. Gupte

Am J Physiol Heart Circ Physiol. 2017 Aug 1; 313(2): H293–H303. Published online 2017 May 26. doi: 10.1152/ajpheart.00785.2016

PMCID:: PMC5582928

Abstract Article

Select item 501908910.

Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice

Sachindra Raj Joshi, Anand Lakhkar, Vidhi Dhagia, Ariadne L. Zias, Vasiliki Soldatos, Kaori Oshima, Houli Jiang, Katherine Gotlinger, Jorge H. Capdevila, Michal L. Schwartzman, Ivan F. McMurtry, Sachin A. Gupte

Pulm Circ. 2016 Sep; 6(3): 360–368. doi: 10.1086/688060

Correction in:: Pulm Circ. 2016 Dec; 6(4): 621.

PMCID:: PMC5019089

Abstract Article PDF–7.8M

Select item 461754011.

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

You Li, Nikolai T. Klena, George C Gabriel, Xiaoqin Liu, Andrew J. Kim, Kristi Lemke, Yu Chen, Bishwanath Chatterjee, William Devine, Rama Rao Damerla, Chien-fu Chang, Hisato Yagi, Jovenal T. San Agustin, Mohamed Thahir, Shane Anderton, Caroline Lawhead, Anita Vescovi, Herbert Pratt, Judy Morgan, Leslie Haynes, Cynthia L. Smith, Janan T. Eppig, Laura Reinholdt, Richard Francis, Linda Leatherbury, Madhavi K. Ganapathiraju, Kimimasa Tobita, Gregory J. Pazour, Cecilia W. Lo

Nature. Author manuscript; available in PMC 2015 Nov 28.

Published in final edited form as: Nature. 2015 May 28; 521(7553): 520–524. Published online 2015 Mar 25. doi: 10.1038/nature14269

PMCID:: PMC4617540

Abstract Article PDF–518K

Select item 413713212.

Cyp2c44 epoxygenase in the collecting duct is essential for the high K⁺ intake-induced antihypertensive effect

Wen-Hui Wang, Chengbiao Zhang, Dao-Hong Lin, Lijun Wang, Joan P. Graves, Darryl C. Zeldin, Jorge H. Capdevila

Am J Physiol Renal Physiol. 2014 Aug 15; 307(4): F453–F460. Published online 2014 Jun 25. doi: 10.1152/ajprenal.00123.2014

PMCID:: PMC4137132

Abstract Article

Select item 396495513.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 392430014.

The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt

Jorge H. Capdevila, Nataliya Pidkovka, Shaojun Mei, Yan Gong, John R. Falck, John D. Imig, Raymond C. Harris, Wenhui Wang

J Biol Chem. 2014 Feb 14; 289(7): 4377–4386. Published online 2013 Dec 24. doi: 10.1074/jbc.M113.508416

PMCID:: PMC3924300

Abstract Article PDF–1.3M

Select item 388245215.

Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney

Ming-Zhi Zhang, Yinqiu Wang, Bing Yao, Leslie Gewin, Shouzuo Wei, Jorge H. Capdevila, Raymond C. Harris

Am J Physiol Renal Physiol. 2013 Dec 15; 305(12): F1680–F1686. Published online 2013 Oct 23. doi: 10.1152/ajprenal.00409.2013

PMCID:: PMC3882452

Abstract Article

Select item 378655516.

The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis

Shiling Yang, Shouzou Wei, Ambra Pozzi, Jorge H. Capdevila

Arch Biochem Biophys. Author manuscript; available in PMC 2013 Sep 30.

Published in final edited form as: Arch Biochem Biophys. 2009 Sep; 489(0): 82–91. Published online 2009 May 21. doi: 10.1016/j.abb.2009.05.006

PMCID:: PMC3786555

Abstract Article PDF–1.9M

Select item 357612617.

Epoxyeicosatrienoic Acids (EETs) Regulate Epithelial Sodium Channel Activity by Extracellular Signal-regulated Kinase 1/2 (ERK1/2)-mediated Phosphorylation

Nataliya Pidkovka, Reena Rao, Shaojun Mei, Yan Gong, Raymond C. Harris, Wen-Hui Wang, Jorge H. Capdevila

J Biol Chem. 2013 Feb 15; 288(7): 5223–5231. Published online 2013 Jan 2. doi: 10.1074/jbc.M112.407981

PMCID:: PMC3576126

Abstract Article PDF–1.0M

Select item 338208618.

Cyp2c44-epoxygenase is essential for preventing the renal sodium absorption during increasing dietary potassium (K)-intake

Peng Sun, Joseph Antoun, Dao-Hong Lin, Peng Yue, Katherine H. Gotlinger, Jorge Capdevila, Wen-Hui Wang

Hypertension. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Hypertension. 2012 Feb; 59(2): 339–347. Published online 2011 Dec 19. doi: 10.1161/HYPERTENSIONAHA.111.178475

PMCID:: PMC3382086

Abstract Article PDF–883K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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