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Select item 110277931.

Ring domains are essential for GATOR2-dependent mTORC1 activation

Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei

Mol Cell. Author manuscript; available in PMC 2024 Apr 19.

Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021

PMCID:: PMC11027793

Abstract Article PDF–3.0M

Select item 105896732.

Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction

Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120

PMCID:: PMC10589673

Abstract Article PDF–6.8M

Select item 100860333.

LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway

Jung-Hsuan Chang, Chia-Hua Chou, Jui-Ching Wu, Keng-Mao Liao, Wei-Jia Luo, Wei-Lun Hsu, Xuan-Ren Chen, Sung-Liang Yu, Szu-Hua Pan, Pan-Chyr Yang, Kang-Yi Su

Commun Biol. 2023; 6: 389. Published online 2023 Apr 10. doi: 10.1038/s42003-023-04778-2

PMCID:: PMC10086033

Abstract Article PDF–5.9M

Select item 98919564.

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai

J Cachexia Sarcopenia Muscle. 2023 Feb; 14(1): 198–213. Published online 2022 Nov 17. doi: 10.1002/jcsm.13121

PMCID:: PMC9891956

Abstract Article PDF–4.2M

Select item 97581775.

Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice

Seok-Ting J. Ang, Elisa M. Crombie, Han Dong, Kuan-Ting Tan, Adriel Hernando, Dejie Yu, Stuart Adamson, Seonyoung Kim, Dominic J. Withers, Hua Huang, Shih-Yin Tsai

Nat Commun. 2022; 13: 7792. Published online 2022 Dec 17. doi: 10.1038/s41467-022-35547-0

PMCID:: PMC9758177

Abstract Article PDF–11M

Select item 92074136.

The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring’s Muscle Development and Energy Homeostasis

Saeed Ghnaimawi, Shilei Zhang, Jamie I. Baum, Yan Huang

Front Physiol. 2022; 13: 881624. Published online 2022 Jun 6. doi: 10.3389/fphys.2022.881624

PMCID:: PMC9207413

Abstract Article PDF–6.0M

Select item 91692317.

A role for translational regulation by S6 kinase and a downstream target in inflammatory pain

June Bryan de la Peña, Nikesh Kunder, Tzu-Fang Lou, Rebecca Chase, Alexander Stanowick, Paulino Barragan-Iglesias, Joseph J. Pancrazio, Zachary T. Campbell

Br J Pharmacol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Br J Pharmacol. 2021 Dec; 178(23): 4675–4690. Published online 2021 Sep 12. doi: 10.1111/bph.15646

PMCID:: PMC9169231

Abstract Article PDF–2.2M

Select item 91374058.

Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum

Ines Serra, Ana Stravs, Catarina Osório, Maria Roa Oyaga, Martijn Schonewille, Christian Tudorache, Aleksandra Badura

Front Mol Neurosci. 2022; 15: 831687. Published online 2022 May 13. doi: 10.3389/fnmol.2022.831687

PMCID:: PMC9137405

Abstract Article PDF–4.0M

Select item 89799889.

S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2

Sang Ah Yi, Ye Ji Jeon, Min Gyu Lee, Ki Hong Nam, Sora Ann, Jaecheol Lee, Jeung-Whan Han

Exp Mol Med. 2022 Mar; 54(3): 324–333. Published online 2022 Mar 25. doi: 10.1038/s12276-022-00747-7

PMCID:: PMC8979988

Abstract Article PDF–3.9M

Select item 878413310.

GATOR2 complex–mediated amino acid signaling regulates brain myelination

Zongyan Yu, Zhiwen Yang, Guoru Ren, Yingjie Wang, Xiang Luo, Feiyan Zhu, Shouyang Yu, Lanlan Jia, Mina Chen, Paul F. Worley, Bo Xiao

Proc Natl Acad Sci U S A. 2022 Jan 18; 119(3): e2110917119. Published online 2022 Jan 12. doi: 10.1073/pnas.2110917119

PMCID:: PMC8784133

Abstract Article PDF–3.3M

Select item 861731111.

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, Katherine A. Rauen

Dis Model Mech. 2022 Feb 1; 15(2): dmm049166. Published online 2021 Nov 19. doi: 10.1242/dmm.049166

PMCID:: PMC8617311

Abstract Article

Select item 859366412.

p70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice

Florian P. Reiter, Liangtao Ye, Andrea Ofner, Tobias S. Schiergens, Andreas Ziesch, Lydia Brandl, Najib Ben Khaled, Simon Hohenester, Ralf Wimmer, Renate Artmann, Yulong He, Serene M.L. Lee, Doris Mayr, Changhua Zhang, Alexander L. Gerbes, Julia Mayerle, Gerald Denk, Enrico N. De Toni

Cell Mol Gastroenterol Hepatol. 2022; 13(1): 95–112. Published online 2021 Sep 17. doi: 10.1016/j.jcmgh.2021.09.001

PMCID:: PMC8593664

Abstract Article PDF–8.0M

Select item 838660013.

Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation

Mingyu Pan, Yue Yin, Xinxia Wang, Quanyi Wang, Lele Zhang, Haiyang Hu, Chen Wang

Autophagy. 2021; 17(8): 1873–1888. Published online 2020 Aug 2. doi: 10.1080/15548627.2020.1796015

PMCID:: PMC8386600

Abstract Article PDF–8.5M

Select item 835604114.

TLR5 Supports Development of Placental Labyrinthine Zone in Mice

Jensen H. C. Yiu, Samson W. M. Cheung, Jieling Cai, Kam-Suen Chan, Jing Chen, Lai Yee Cheong, Hau-Tak Chau, Aimin Xu, Raymond H. W. Li, Connie W. Woo

Front Cell Dev Biol. 2021; 9: 711253. Published online 2021 Jul 28. doi: 10.3389/fcell.2021.711253

PMCID:: PMC8356041

Abstract Article PDF–4.6M

Select item 834314015.

Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice

Cory Parks, Chris M. Rogers, Pjotr Prins, Robert W. Williams, Hao Chen, Byron C. Jones, Bob M. Moore, II, Megan K. Mulligan

Front Genet. 2021; 12: 659012. Published online 2021 Jul 23. doi: 10.3389/fgene.2021.659012

PMCID:: PMC8343140

Abstract Article PDF–2.0M

Select item 831912316.

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies

Gerald C. Tiu, Craig H. Kerr, Craig M. Forester, Pallavi S. Krishnarao, Hannah D. Rosenblatt, Nitin Raj, Travis C. Lantz, Olena Zhulyn, Margot E. Bowen, Leila Shokat, Laura D. Attardi, Davide Ruggero, Maria Barna

Dev Cell. Author manuscript; available in PMC 2022 Jul 26.

Published in final edited form as: Dev Cell. 2021 Jul 26; 56(14): 2089–2102.e11. Published online 2021 Jul 8. doi: 10.1016/j.devcel.2021.06.013

PMCID:: PMC8319123

Abstract Article PDF–2.5M

Select item 810635217.

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice

Sameer Aryal, Francesco Longo, Eric Klann

Proc Natl Acad Sci U S A. 2021 May 4; 118(18): e2001681118. Published online 2021 Apr 27. doi: 10.1073/pnas.2001681118

PMCID:: PMC8106352

Abstract Article PDF–2.2M

Select item 807377318.

S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux

Aleksandra Hać, Karolina Pierzynowska, Anna Herman-Antosiewicz

Cells. 2021 Apr; 10(4): 929. Published online 2021 Apr 17. doi: 10.3390/cells10040929

PMCID:: PMC8073773

Abstract Article PDF–6.2M

Select item 785452419.

Maternal Immune Activation in Mice Disrupts Proteostasis in the Fetal Brain

Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh

Nat Neurosci. Author manuscript; available in PMC 2021 Jun 23.

Published in final edited form as: Nat Neurosci. 2021 Feb; 24(2): 204–213. Published online 2020 Dec 23. doi: 10.1038/s41593-020-00762-9

PMCID:: PMC7854524

Abstract Article PDF–5.7M

Select item 784655720.

The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization

Andres Ramirez-Martinez, Yichi Zhang, Kenian Chen, Jiwoong Kim, Bercin K. Cenik, John R. McAnally, Chunyu Cai, John M. Shelton, Jian Huang, Ana Brennan, Bret M. Evers, Pradeep P. A. Mammen, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

Nat Commun. 2021; 12: 690. Published online 2021 Jan 29. doi: 10.1038/s41467-021-20987-x