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Select item 110726781.

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

Gimena Fernandez, Agustina Cabral, Pablo N. De Francesco, Maia Uriarte, Mirta Reynaldo, Daniel Castrogiovanni, Guillermina Zubiría, Andrés Giovambattista, Sonia Cantel, Severine Denoyelle, Jean-Alain Fehrentz, Virginie Tolle, Helgi B. Schiöth, Mario Perello

Cell Mol Life Sci. 2022 May; 79(5): 277. Published online 2022 May 4. doi: 10.1007/s00018-022-04302-5

PMCID:: PMC11072678

Abstract Article PDF–9.0M

Select item 109202422.

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation

Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G. Geoffroy, Sunja Kim, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun

Front Immunol. 2024; 15: 1339937. Published online 2024 Feb 23. doi: 10.3389/fimmu.2024.1339937

PMCID:: PMC10920242

Abstract Article PDF–3.2M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108417204.

Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging

Jing Tian, Eric Du, Kun Jia, Tienju Wang, Lan Guo, Jeffrey M. Zigman, Heng Du

J Alzheimers Dis. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: J Alzheimers Dis. 2023; 96(4): 1579–1592. doi: 10.3233/JAD-231002

PMCID:: PMC10841720

Abstract Article PDF–1.9M

Select item 107728245.

Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation

Da Mi Kim, Jong Han Lee, Quan Pan, Hye Won Han, Zheng Shen, Sahar Eshghjoo, Chia-Shan Wu, Wanbao Yang, Ji Yeon Noh, David W. Threadgill, Shaodong Guo, Gus Wright, Robert Alaniz, Yuxiang Sun

Mol Metab. 2024 Jan; 79: 101852. Published online 2023 Dec 12. doi: 10.1016/j.molmet.2023.101852

PMCID:: PMC10772824

Abstract Article PDF–3.7M

Select item 103787566.

Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice

Xiangcang Ye, Zeyu Liu, Hye Won Han, Ji Yeon Noh, Zheng Shen, Da Mi Kim, Hongying Wang, Huiping Guo, Johnathan Ballard, Andrei Golovko, Benjamin Morpurgo, Yuxiang Sun

Genes (Basel) 2023 Jul; 14(7): 1455. Published online 2023 Jul 16. doi: 10.3390/genes14071455

PMCID:: PMC10378756

Abstract Article PDF–3.1M

Select item 103226947.

Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

Jing Tian, Lan Guo, Tienju Wang, Kun Jia, Russell H. Swerdlow, Jeffrey M. Zigman, Heng Du

JCI Insight. 2023 May 22; 8(10): e166175. Published online 2023 May 22. doi: 10.1172/jci.insight.166175

PMCID:: PMC10322694

Abstract Article PDF–8.6M

Select item 96683368.

Molecular and anatomical characterization of parabrachial neurons and their axonal projections

Jordan L Pauli, Jane Y Chen, Marcus L Basiri, Sekun Park, Matthew E Carter, Elisenda Sanz, G Stanley McKnight, Garret D Stuber, Richard D Palmiter

eLife. 2022; 11: e81868. Published online 2022 Nov 1. doi: 10.7554/eLife.81868

PMCID:: PMC9668336

Abstract Article PDF–6.0M

Select item 95998229.

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity

Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J. Degroat, Yuxiang Sun, Troy A. Roepke

Biomolecules. 2022 Oct; 12(10): 1370. Published online 2022 Sep 25. doi: 10.3390/biom12101370

PMCID:: PMC9599822

Abstract Article PDF–4.6M

Select item 940720810.

Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle

Colleen O’Reilly, Ligen Lin, Hongying Wang, James Fluckey, Yuxiang Sun

Genes (Basel) 2022 Aug; 13(8): 1368. Published online 2022 Jul 30. doi: 10.3390/genes13081368

PMCID:: PMC9407208

Abstract Article PDF–1.8M

Select item 929703511.

Molecularly defined circuits for cardiovascular and cardiopulmonary control

Avin Veerakumar, Andrea R. Yung, Yin Liu, Mark A. Krasnow

Nature. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Nature. 2022 Jun; 606(7915): 739–746. Published online 2022 Jun 1. doi: 10.1038/s41586-022-04760-8

PMCID:: PMC9297035

Abstract Article PDF–7.2M

Select item 896177612.

Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions

Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Sun

Biomolecules. 2022 Feb; 12(2): 293. Published online 2022 Feb 11. doi: 10.3390/biom12020293

PMCID:: PMC8961776

Abstract Article PDF–1.0M

Select item 894599813.

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets

Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun

Biomolecules. 2022 Mar; 12(3): 407. Published online 2022 Mar 6. doi: 10.3390/biom12030407

PMCID:: PMC8945998

Abstract Article PDF–1.6M

Select item 891583014.

Discovery of a functionally selective ghrelin receptor (GHSR_1a) ligand for modulating brain dopamine

J. D. Gross, D. W. Kim, Y. Zhou, D. Jansen, L. M. Slosky, N. B. Clark, C. R. Ray, X. Hu, N. Southall, A. Wang, X. Xu, E. Barnaeva, W. C. Wetsel, M. Ferrer, J. J. Marugan, M. G. Caron, L. S. Barak, K. Toth

Proc Natl Acad Sci U S A. 2022 Mar 8; 119(10): e2112397119. Published online 2022 Mar 3. doi: 10.1073/pnas.2112397119

PMCID:: PMC8915830

Abstract Article PDF–2.2M

Select item 883407715.

LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner

Javier Lugilde, Sabela Casado, Daniel Beiroa, Juan Cuñarro, Montserrat Garcia-Lavandeira, Clara V. Álvarez, Rubén Nogueiras, Carlos Diéguez, Sulay Tovar

Cells. 2022 Feb; 11(3): 324. Published online 2022 Jan 19. doi: 10.3390/cells11030324

PMCID:: PMC8834077

Abstract Article PDF–1.4M

Select item 878260816.

FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth

Caitlin E Stallings, Jyoti Kapali, Brian W Evans, Stacey R McGee, Buffy S Ellsworth

Endocrinology. 2022 Feb; 163(2): bqab263. Published online 2021 Dec 31. doi: 10.1210/endocr/bqab263

PMCID:: PMC8782608

Abstract Article

Select item 851735817.

Growth hormone secretagogue receptor‐1a mediates ghrelin's effects on attenuating tumour‐induced loss of muscle strength but not muscle mass

Haiming Liu, Pu Zang, Ian (In‐gi) Lee, Barbara Anderson, Anthony Christiani, Lena Strait‐Bodey, Beatrice A. Breckheimer, Mackenzie Storie, Alison Tewnion, Kora Krumm, Theresa Li, Brynn Irwin, Jose M. Garcia

J Cachexia Sarcopenia Muscle. 2021 Oct; 12(5): 1280–1295. Published online 2021 Jul 15. doi: 10.1002/jcsm.12743

PMCID:: PMC8517358

Abstract Article PDF–12M

Select item 851328118.

Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding

Nan Li, Na Li, Fenghua Xu, Ming Yu, Zichen Qiao, Yu Zhou

Mol Brain. 2021; 14: 157. Published online 2021 Oct 12. doi: 10.1186/s13041-021-00866-8

PMCID:: PMC8513281

Abstract Article PDF–2.5M

Select item 837990119.

High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets

Deepali Gupta, Georgina K C Dowsett, Bharath K Mani, Kripa Shankar, Sherri Osborne-Lawrence, Nathan P Metzger, Brian Y H Lam, Giles S H Yeo, Jeffrey M Zigman

Endocrinology. 2021 Oct; 162(10): bqab148. Published online 2021 Jul 21. doi: 10.1210/endocr/bqab148

PMCID:: PMC8379901

Abstract Article

Select item 820384620.

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman

Mol Metab. 2021 Nov; 53: 101258. Published online 2021 May 21. doi: 10.1016/j.molmet.2021.101258

PMCID:: PMC8203846

Abstract Article PDF–2.6M

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