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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 112062212.

CRL4^DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development

Xiao-Ran Han, Naoya Sasaki, Sarah C. Jackson, Pu Wang, Zhijun Li, Matthew D. Smith, Ling Xie, Xian Chen, Yanping Zhang, William F. Marzluff, Yue Xiong

Sci Adv. 2020 Dec; 6(51): eabd6078. Published online 2020 Dec 18. doi: 10.1126/sciadv.abd6078

PMCID:: PMC11206221

Abstract Article PDF–2.7M

Select item 110558683.

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer

Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao

Nat Commun. 2024; 15: 3581. Published online 2024 Apr 27. doi: 10.1038/s41467-024-47987-x

PMCID:: PMC11055868

Abstract Article PDF–4.0M

Select item 109856674.

NEDD8在不同病理类型慢性鼻窦炎伴鼻息肉中的表达差异

孟琛, 闫冰, 黄雨晴, 王成硕, 张罗

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Nov 3; 37(11): 897–901. Chinese. doi: 10.13201/j.issn.2096-7993.2023.11.008

PMCID:: PMC10985667

Abstract Article PDF–2.3M

Select item 109197585.

Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review)

Tianyu Wang, Xiaobing Li, Ruijie Ma, Jian Sun, Shuhong Huang, Zhigang Sun, Meng Wang

Int J Oncol. 2024 Apr; 64(4): 39. Published online 2024 Feb 21. doi: 10.3892/ijo.2024.5627

PMCID:: PMC10919758

Abstract Article PDF–2.4M

Select item 104762816.

The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs

Anna Stier, Samuel Gilberto, Weaam I Mohamed, Lars N Royall, Jonne Helenius, Ivan Mikicic, Tatjana Sajic, Petra Beli, Daniel J Müller, Sebastian Jessberger, Matthias Peter

EMBO J. 2023 Sep; 42(17): e112847. Published online 2023 Jun 27. doi: 10.15252/embj.2022112847

PMCID:: PMC10476281

Abstract Article PDF–2.6M

Select item 103719877.

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development

Anthony J. Asmar, Shaun R. Abrams, Jenny Hsin, Jason C. Collins, Rita M. Yazejian, Youmei Wu, Jean Cho, Andrew D. Doyle, Samhitha Cinthala, Marleen Simon, Richard H. van Jaarsveld, David B. Beck, Laura Kerosuo, Achim Werner

Nat Commun. 2023; 14: 4499. Published online 2023 Jul 26. doi: 10.1038/s41467-023-40223-y

PMCID:: PMC10371987

Abstract Article PDF–3.9M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100807269.

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity

Daniel C. Scott, Moeko T. King, Kheewoong Baek, Clifford T. Gee, Ravi Kalathur, Jerry Li, Nicholas Purser, Amanda Nourse, Sergio C. Chai, Sivaraja Vaithiyalingam, Taosheng Chen, Richard E. Lee, Stephen J. Elledge, Gary Kleiger, Brenda A. Schulman

Mol Cell. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 770–786.e9. Published online 2023 Feb 16. doi: 10.1016/j.molcel.2023.01.019

PMCID:: PMC10080726

Abstract Article PDF–3.0M

Select item 1007290610.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 983051511.

Neddylation of HER2 Inhibits its Protein Degradation and promotes Breast Cancer Progression

Xiaohong Xia, Tumei Hu, Xiaoyue He, Yuan Liu, Cuifu Yu, Weiyao Kong, Yuning Liao, Daolin Tang, Jinbao Liu, Hongbiao Huang

Int J Biol Sci. 2023; 19(2): 377–392. Published online 2023 Jan 1. doi: 10.7150/ijbs.75852

PMCID:: PMC9830515

Abstract Article PDF–11M

Select item 976969812.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 954034513.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 951327114.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 945097915.

HYPK coordinates degradation of polyneddylated proteins by autophagy

Debasish Kumar Ghosh, Akash Ranjan

Autophagy. 2022; 18(8): 1763–1784. Published online 2021 Nov 26. doi: 10.1080/15548627.2021.1997053

PMCID:: PMC9450979

Abstract Article PDF–6.3M

Select item 927928516.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 917141117.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973618.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523519.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 902051720.

Structural and functional consequences of NEDD8 phosphorylation

Katrin Stuber, Tobias Schneider, Jill Werner, Michael Kovermann, Andreas Marx, Martin Scheffner

Nat Commun. 2021; 12: 5939. Published online 2021 Oct 12. doi: 10.1038/s41467-021-26189-9

PMCID:: PMC9020517

Abstract Article PDF–2.8M

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