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Select item 114285691.

CD9 promotes TβR2–TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia

Wanqi Huang, Ze Zhang, Xin Li, Qingqing Zheng, Chao Wu, Luojia Liu, Ying Chen, Jiaping Zhang, Xupin Jiang

Mol Med. 2024; 30: 162. Published online 2024 Sep 27. doi: 10.1186/s10020-024-00925-5

PMCID:: PMC11428569

Abstract Article PDF–8.4M

Select item 114258682.

Stabilization of TGF‐β Receptor 1 by a Receptor‐Associated Adaptor Dictates Feedback Activation of the TGF‐β Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance

Kewei Liu, Fanxuan Tian, Xu Chen, Biyin Liu, Shuoran Tian, Yongying Hou, Lei Wang, Mengyi Han, Shiying Peng, Yuting Tan, Yuwei Pan, Zhaole Chu, Jinyang Li, Linrong Che, Dongfeng Chen, Liangzhi Wen, Zhongyi Qin, Xianfeng Li, Junyu Xiang, Xiu‐wu Bian, Qin Liu, Xiaoli Ye, Tao Wang, Bin Wang

Adv Sci (Weinh) 2024 Sep; 11(34): 2402327. Published online 2024 Jul 9. doi: 10.1002/advs.202402327

PMCID:: PMC11425868

Abstract Article PDF–6.6M

Select item 113030713.

ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation

Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen

Theranostics. 2024; 14(11): 4536–4553. Published online 2024 Jul 22. doi: 10.7150/thno.95796

PMCID:: PMC11303071

Abstract Article PDF–15M

Select item 111510764.

TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2

Huiqi Tan, Mia Xinfang Miao, Rylee Xu Luo, Joan So, Lei Peng, Xiaoxuan Zhu, Eva Hin Wa Leung, Lina Zhu, Kui Ming Chan, Martin Cheung, Siu Yuen Chan

Adv Sci (Weinh) 2024 Jun; 11(21): 2306486. Published online 2024 Apr 8. doi: 10.1002/advs.202306486

PMCID:: PMC11151076

Abstract Article PDF–6.4M

Select item 102722775.

USP33 promotes pancreatic cancer malignant phenotype through the regulation of TGFBR2/TGFβ signaling pathway

Xinyuan Liu, Jian Xu, Bingbing shen, Jichuan Xu, Jianxin Jiang

Cell Death Dis. 2023 Jun; 14(6): 362. Published online 2023 Jun 15. doi: 10.1038/s41419-023-05871-4

PMCID:: PMC10272277

Abstract Article PDF–9.4M

Select item 101838276.

LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation

Chuannan Fan, Qian Wang, Thomas B Kuipers, Davy Cats, Prasanna Vasudevan Iyengar, Sophie C Hagenaars, Wilma E Mesker, Peter Devilee, Rob A E M Tollenaar, Hailiang Mei, Peter ten Dijke

EMBO J. 2023 May; 42(10): e112806. Published online 2023 Mar 30. doi: 10.15252/embj.2022112806

PMCID:: PMC10183827

Abstract Article PDF–5.6M

Select item 101721887.

Truncating variants in the penultimate exon of TGFBR1 escaping nonsense-mediated mRNA decay cause Loeys-Dietz syndrome

Paola Fortugno, Rosanna Monetta, Valeria Cinquina, Chiara Rigon, Francesca Boaretto, Chiara De Luca, Nicoletta Zoppi, Luana Di Leandro, Emanuela De Domenico, Arianna Di Daniele, Rodolfo Ippoliti, Francesco Angelucci, Ernesto Di Cesare, Ruggero De Paulis, Leonardo Salviati, Marina Colombi, Francesco Brancati, Marco Ritelli

Eur J Hum Genet. 2023 May; 31(5): 596–601. Published online 2023 Jan 4. doi: 10.1038/s41431-022-01279-4

PMCID:: PMC10172188

Abstract Article PDF–5.0M

Select item 100729068.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100653259.

Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis

Karina Colombera Peres, Larissa Teodoro, Laís Helena Pereira Amaral, Elisângela Souza Teixeira, Icléia Siqueira Barreto, Leandro Luiz Lopes de Freitas, Valdemar Maximo, Lígia V. Montalli Assumpção, Natassia Elena Bufalo, Laura Sterian Ward

Arch Endocrinol Metab. 2021 Mar-Apr; 65(2): 172–184. Published online 2021 Feb 25. doi: 10.20945/2359-3997000000330

PMCID:: PMC10065325

Abstract Article PDF–421K

Select item 1003667010.

Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells

Xinyue Li, Navneet Kaur, Mustafa Albahrani, Adam R. Karpf, Adrian R. Black, Jennifer D. Black

J Biol Chem. 2023 Apr; 299(4): 103017. Published online 2023 Feb 13. doi: 10.1016/j.jbc.2023.103017

PMCID:: PMC10036670

Abstract Article PDF–1.6M

Select item 999017811.

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Zhi-yuan Zhang, Cui-yu Ju, Liu-zheng Wu, Han Yan, Wen-bin Hong, Hang-zi Chen, Peng-bo Yang, Bao-Rui Wang, Tong Gou, Xiao-yan Chen, Zhi-hong Jiang, Wei-jia Wang, Tianwei Lin, Fu-nan Li, Qiao Wu

Cell Chem Biol. 2023 Mar 16; 30(3): 261–277.e8. Published online 2023 Mar 7. doi: 10.1016/j.chembiol.2023.02.004

PMCID:: PMC9990178

Abstract Article PDF–6.9M

Select item 988875612.

Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes

Alanna Strong, Cara Skraban, Kevin Meyers, Sandra Amaral, Susan Furth, Stacey Drant, Wendy Hsiao, Lauren Galea, Jessica Gold, Nina B. Gold, Jacqueline Leonard, Sonya Lopez, Elaine H. Zackai, Reed E. Pyeritz

Am J Med Genet A. Author manuscript; available in PMC 2023 Jan 31.

Published in final edited form as: Am J Med Genet A. 2021 Dec; 185(12): 3762–3769. Published online 2021 Aug 6. doi: 10.1002/ajmg.a.62449

PMCID:: PMC9888756

Abstract Article PDF–1.0M

Select item 984259113.

Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial–mesenchymal transition of breast cancer cells

Jing Zhang, Maarten van Dinther, Midory Thorikay, Babak Mousavi Gourabi, Boudewijn P. T. Kruithof, Peter ten Dijke

Cell Mol Life Sci. 2023 Feb; 80(2): 43. Published online 2023 Jan 17. doi: 10.1007/s00018-022-04672-w

PMCID:: PMC9842591

Abstract Article PDF–14M

Select item 952876014.

GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/β‐catenin and ALK5/SMAD2/3 pathways

Jan Frohlich, Kristina Kovacovicova, Marco Raffaele, Tereza Virglova, Eliska Cizkova, Jan Kucera, Julie Bienertova‐Vasku, Martin Wabitsch, Marion Peyrou, Francesca Bonomini, Rita Rezzani, George N. Chaldakov, Anton B. Tonchev, Michelino Di Rosa, Nicolas Blavet, Vaclav Hejret, Manlio Vinciguerra

Cell Prolif. 2022 Oct; 55(10): e13310. Published online 2022 Aug 3. doi: 10.1111/cpr.13310

PMCID:: PMC9528760

Abstract Article PDF–3.7M

Select item 938672615.

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Jie Song, Yang Zhou, Ihor Yakymovych, Alexej Schmidt, Chunyan Li, Carl-Henrik Heldin, Maréne Landström

eBioMedicine. 2022 Aug; 82: 104155. Published online 2022 Jul 16. doi: 10.1016/j.ebiom.2022.104155

PMCID:: PMC9386726

Abstract Article PDF–5.3M

Select item 923162316.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 920157217.

Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction

Junju Zou, Xiaotao Zhou, Xian Chen, Yuerong Ma, Rong Yu

Front Pharmacol. 2022; 13: 849832. Published online 2022 Jun 2. doi: 10.3389/fphar.2022.849832

PMCID:: PMC9201572

Abstract Article PDF–7.1M

Select item 917141118.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973619.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 900518720.

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Michèle MG Hillege, Andi Shi, Ricardo A Galli, Gang Wu, Philippe Bertolino, Willem MH Hoogaars, Richard T Jaspers

eLife. 2022; 11: e77610. Published online 2022 Mar 24. doi: 10.7554/eLife.77610

PMCID:: PMC9005187

Abstract Article PDF–8.5M

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