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Select item 107620351.

Molecular basis of human trace amine-associated receptor 1 activation

Gregory Zilberg, Alexandra K. Parpounas, Audrey L. Warren, Shifan Yang, Daniel Wacker

Nat Commun. 2024; 15: 108. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44601-4

PMCID:: PMC10762035

Abstract Article PDF–2.6M

Select item 103809172.

T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line

Beatrice Polini, Caterina Ricardi, Andrea Bertolini, Vittoria Carnicelli, Grazia Rutigliano, Federica Saponaro, Riccardo Zucchi, Grazia Chiellini

Int J Mol Sci. 2023 Jul; 24(14): 11569. Published online 2023 Jul 17. doi: 10.3390/ijms241411569

PMCID:: PMC10380917

Abstract Article PDF–2.8M

Select item 96303863.

TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT_1A receptor agonist SEP-363856

Marcus Saarinen, Ioannis Mantas, Ivana Flais, Richard Ågren, Kristoffer Sahlholm, Mark J. Millan, Per Svenningsson

Neuropsychopharmacology. 2022 Dec; 47(13): 2319–2329. Published online 2022 Sep 13. doi: 10.1038/s41386-022-01421-2

Correction in:: Neuropsychopharmacology. 2023 Apr; 48(5): 846.

PMCID:: PMC9630386

Abstract Article PDF–2.1M

Select item 87457184.

Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors

Anna V. Glyakina, Constantine D. Pavlov, Julia V. Sopova, Raul R. Gainetdinov, Elena I. Leonova, Oxana V. Galzitskaya

Int J Mol Sci. 2022 Jan; 23(1): 209. Published online 2021 Dec 25. doi: 10.3390/ijms23010209

PMCID:: PMC8745718

Abstract Article PDF–5.1M

Select item 85840015.

TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation

David A. Barnes, Dylan A. Galloway, Marius C. Hoener, Mark D. Berry, Craig S. Moore

Int J Mol Sci. 2021 Nov; 22(21): 11576. Published online 2021 Oct 27. doi: 10.3390/ijms222111576

PMCID:: PMC8584001

Abstract Article PDF–1.4M

Select item 83951826.

Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer

Tilman L. R. Vogelsang, Aurelia Vattai, Elisa Schmoeckel, Till Kaltofen, Anca Chelariu-Raicu, Mingjun Zheng, Sven Mahner, Doris Mayr, Udo Jeschke, Fabian Trillsch

Int J Mol Sci. 2021 Aug; 22(16): 8479. Published online 2021 Aug 6. doi: 10.3390/ijms22168479

PMCID:: PMC8395182

Abstract Article PDF–4.8M

Select item 70385767.

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα₁₃ and Gα_S in discrete subcellular domains

Suzanne M. Underhill, Patrick D. Hullihen, Jingshan Chen, Cristina Fenollar-Ferrer, M. A. Rizzo, Susan L. Ingram, Susan G. Amara

Mol Psychiatry. 2021; 26(4): 1208–1223. Published online 2019 Aug 9. doi: 10.1038/s41380-019-0469-2

PMCID:: PMC7038576

Abstract Article PDF–2.5M

Select item 67865818.

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence

Jennifer M. Loftis, Michael Lasarev, Xiao Shi, Jodi Lapidus, Aaron Janowsky, William F. Hoffman, Marilyn Huckans

PLoS One. 2019; 14(10): e0220270. Published online 2019 Oct 10. doi: 10.1371/journal.pone.0220270

PMCID:: PMC6786581

Abstract Article PDF–814K

Select item 67443919.

Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2

Xiao Shi, Tracy L. Swanson, Nicholas B. Miner, Amy J. Eshleman, Aaron Janowsky

Mol Pharmacol. 2019 Oct; 96(4): 493–504. Published online 2019 Oct. doi: 10.1124/mol.119.116798

PMCID:: PMC6744391

Abstract Article PDF–1.3M

Select item 662386110.

Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)

Benjamin Di Cara, Roberto Maggio, Gabriella Aloisi, Jean-Michel Rivet, Ebba Gregorsson Lundius, Takashi Yoshitake, Per Svenningsson, Mauricette Brocco, Alain Gobert, Lotte De Groote, Laetitia Cistarelli, Sylvie Veiga, Catherine De Montrion, Marianne Rodriguez, Jean-Pierre Galizzi, Brian P. Lockhart, Francis Cogé, Jean A. Boutin, Philippe Vayer, P. Monika Verdouw, Lucianne Groenink, Mark J. Millan

J Neurosci. 2011 Nov 23; 31(47): 16928–16940. doi: 10.1523/JNEUROSCI.2502-11.2011

PMCID:: PMC6623861

Abstract Article PDF–1.2M

Select item 629936811.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 556900212.

Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia

Jibin John, Prachi Kukshal, Triptish Bhatia, K.V. Chowdari, V.L. Nimgaonkar, S.N. Deshpande, B.K. Thelma

Schizophr Res. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Schizophr Res. 2017 Nov; 189: 190–195. Published online 2017 Feb 24. doi: 10.1016/j.schres.2017.02.020

PMCID:: PMC5569002

Abstract Article PDF–364K

Select item 537173013.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 481655714.

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function

Xiao Shi, Nicole A. R. Walter, John H. Harkness, Kim A. Neve, Robert W. Williams, Lu Lu, John K. Belknap, Amy J. Eshleman, Tamara J. Phillips, Aaron Janowsky

PLoS One. 2016; 11(3): e0152581. Published online 2016 Mar 31. doi: 10.1371/journal.pone.0152581