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Select item 111535341.

Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging

Takeru Odawara, Shota Yamauchi, Hidenori Ichijo

Commun Biol. 2024; 7: 691. Published online 2024 Jun 5. doi: 10.1038/s42003-024-06386-0

PMCID:: PMC11153534

Abstract Article PDF–2.1M

Select item 108969142.

Apoptosis signal-regulating kinase 1 (Ask1) deficiency alleviates MPP⁺-induced impairment of evoked dopamine release in the mouse hippocampus

Fang Zhao, Chuhan Li, Yinghan Zhuang, Yan Yan, Yanqin Gao, Thomas Behnisch

Front Cell Neurosci. 2024; 18: 1288991. Published online 2024 Feb 13. doi: 10.3389/fncel.2024.1288991

PMCID:: PMC10896914

Abstract Article PDF–19M

Select item 97348053.

ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis

Ri Tang, Shuya Mei, Qiaoyi Xu, Jinhua Feng, Yang Zhou, Shunpeng Xing, Zhengyu He, Yuan Gao

Exp Mol Med. 2022 Dec; 54(12): 2162–2174. Published online 2022 Dec 6. doi: 10.1038/s12276-022-00901-1

PMCID:: PMC9734805

Abstract Article PDF–30M

Select item 96227264.

Thioredoxin-interacting protein deficiency protects against severe acute pancreatitis by suppressing apoptosis signal-regulating kinase 1

Yanna Liu, Mengke Li, Chaopeng Mei, Huning Cui, Qiaofang Wang, Dejian Li, Yaodong Song, Mengwei Cui, Qianqian He, Sanyang Chen, Changju Zhu

Cell Death Dis. 2022 Oct; 13(10): 914. Published online 2022 Oct 31. doi: 10.1038/s41419-022-05355-x

PMCID:: PMC9622726

Abstract Article PDF–12M

Select item 93151265.

Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target

Vaibhav Singh, Emily Huang, Vai Pathak, Belinda B. Willard, Daniela S. Allende, Laura E. Nagy

Hepatol Commun. 2022 Aug; 6(8): 2022–2041. Published online 2022 Apr 19. doi: 10.1002/hep4.1956

PMCID:: PMC9315126

Abstract Article PDF–11M

Select item 91105056.

ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death

Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David J. Nikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart

J Mol Med (Berl) 2022; 100(5): 797–813. Published online 2022 Apr 26. doi: 10.1007/s00109-022-02188-1

Correction in:: J Mol Med (Berl). 2022; 100(5): 815.

PMCID:: PMC9110505

Abstract Article PDF–3.6M

Select item 88329697.

ASK1 signaling regulates phase-specific glial interactions during neuroinflammation

Xiaoli Guo, Atsuko Kimura, Kazuhiko Namekata, Chikako Harada, Nobutaka Arai, Kohsuke Takeda, Hidenori Ichijo, Takayuki Harada

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2103812119. Published online 2022 Jan 31. doi: 10.1073/pnas.2103812119

PMCID:: PMC8832969

Abstract Article PDF–3.0M

Select item 87467648.

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith, Julie A. Jonassen, Kenley M. Preval, Roger J. Davis, Gregory J. Pazour

PLoS Genet. 2021 Dec; 17(12): e1009711. Published online 2021 Dec 28. doi: 10.1371/journal.pgen.1009711

PMCID:: PMC8746764

Abstract Article PDF–7.1M

Select item 85810499.

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

Saki Takayanagi, Kengo Watanabe, Takeshi Maruyama, Motoyuki Ogawa, Kazuhiro Morishita, Mayumi Soga, Tomohisa Hatta, Tohru Natsume, Tomoya Hirano, Hiroyuki Kagechika, Kazuki Hattori, Isao Naguro, Hidenori Ichijo

Sci Rep. 2021; 11: 22009. Published online 2021 Nov 10. doi: 10.1038/s41598-021-01123-7

PMCID:: PMC8581049

Abstract Article PDF–3.9M

Select item 801921410.

ASK1 suppresses NK cell‐mediated intravascular tumor cell clearance in lung metastasis

Makoto Fujimoto, Miki Kamiyama, Kosuke Fuse, Hiroki Ryuno, Takeru Odawara, Natsuki Furukawa, Yasuhiro Yoshimatsu, Tetsuro Watabe, Michaela Prchal‐Murphy, Veronika Sexl, Hideaki Tahara, Yoshihiro Hayakawa, Takehiro Sato, Kohsuke Takeda, Isao Naguro, Hidenori Ichijo

Cancer Sci. 2021 Apr; 112(4): 1633–1643. Published online 2021 Mar 6. doi: 10.1111/cas.14842

PMCID:: PMC8019214

Abstract Article PDF–1.2M

Select item 794896011.

Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity

Andrea Iorga, Katherine Donovan, Layla Shojaie, Heather Johnson, Janet Kwok, Jo Suda, Brian T. Lee, Mariam Aghajan, Ling Shao, Zhang-Xu Liu, Lily Dara

J Biol Chem. 2021 Jan-Jun; 296: 100300. Published online 2021 Jan 16. doi: 10.1016/j.jbc.2021.100300

PMCID:: PMC7948960

Abstract Article PDF–2.4M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 783197513.

ASK1 Regulates Immune-Mediated Thrombocytopenia, Thrombosis, and Systemic Shock

Pravin Patel, Noor F. Shaik, Yuhang Zhou, Kalyan Golla, Steven E. McKenzie, Ulhas P. Naik

J Thromb Haemost. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Thromb Haemost. 2020 Nov; 18(11): 3013–3028. Published online 2020 Sep 9. doi: 10.1111/jth.15049

PMCID:: PMC7831975

Abstract Article PDF–2.9M

Select item 779743414.

ASK1/p38-mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy

Wenjun Zou, Shasha Luo, Zhengwei Zhang, Libo Cheng, Xiaoli Huang, Nannan Ding, Ying Pan, Zhifeng Wu

Int J Mol Med. 2021 Feb; 47(2): 732–740. Published online 2020 Dec 24. doi: 10.3892/ijmm.2020.4833

PMCID:: PMC7797434

Abstract Article PDF–1.5M

Select item 779116715.

MicroRNA‐146b‐5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38‐Mapk pathway and γH2A.X phosphorylation

Te Liu, Jiajia Lin, Chuan Chen, Xiaoli Nie, Fangfang Dou, Jiulin Chen, Zhenxin Wang, Zhangbin Gong

Cell Prolif. 2021 Jan; 54(1): e12954. Published online 2020 Nov 9. doi: 10.1111/cpr.12954

PMCID:: PMC7791167

Abstract Article PDF–3.1M

Select item 771442216.

Depletion of ASK1 blunts stress-induced senescence in adipocytes

Stephan Wueest, Fabrizio C. Lucchini, Yulia Haim, Assaf Rudich, Daniel Konrad

Adipocyte. 2020; 9(1): 535–541. Published online 2020 Sep 15. doi: 10.1080/21623945.2020.1815977

PMCID:: PMC7714422

Abstract Article PDF–777K

Select item 759102917.

β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes

Kazuki Hattori, Hiroaki Wakatsuki, Chihiro Sakauchi, Shotaro Furutani, Sho Sugawara, Tomohisa Hatta, Tohru Natsume, Hidenori Ichijo

PLoS One. 2020; 15(10): e0232645. Published online 2020 Oct 27. doi: 10.1371/journal.pone.0232645

PMCID:: PMC7591029

Abstract Article PDF–1.9M

Select item 745388718.

Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms

Jing Ma, Haixia Cao, Robim M. Rodrigues, Mingjiang Xu, Tianyi Ren, Yong He, Seonghwan Hwang, Dechun Feng, Ruixue Ren, Peixin Yang, Suthat Liangpunsakul, Jian Sun, Bin Gao

JCI Insight. 2020 Jul 23; 5(14): e136496. Published online 2020 Jul 23. doi: 10.1172/jci.insight.136496

PMCID:: PMC7453887

Abstract Article PDF–15M

Select item 741599119.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 734816720.

ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6‐mediated Lysine 6‐linked polyubiquitination of ASK1 in hepatocytes

Xiaoliang Xu, Zechuan Zhang, Yijun Lu, Qikai Sun, Yang Liu, Qiaoyu Liu, Wenfang Tian, Yin Yin, Hailong Yu, Beicheng Sun

J Cell Mol Med. 2020 Jul; 24(14): 7814–7828. Published online 2020 May 23. doi: 10.1111/jcmm.15412

PMCID:: PMC7348167

Abstract Article PDF–2.5M

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