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Items: 1 to 20 of 50

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Identification of new ciliary signaling pathways in the brain and insights into neurological disorders
Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz
Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700
PMCID:
PMC10769350
AbstractArticlePDF–11M
3.
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors
Mritunjay Pandey, Jian-Hua Zhang, Poorni R. Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B. Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F. Simonds
JCI Insight. 2023 Jul 10; 8(13): e134685. Published online 2023 Jul 10. doi: 10.1172/jci.insight.134685
PMCID:
PMC10371342
AbstractArticlePDF–8.1M
4.
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x
PMCID:
PMC9938216
AbstractArticlePDF–5.3M
5.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
6.
Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells
Yanghui Sheng, Lujing Chen, Xiaozhi Ren, Zheng Jiang, King-Wai Yau
Sci Rep. 2021; 11: 23424. Published online 2021 Dec 6. doi: 10.1038/s41598-021-02832-9
PMCID:
PMC8648817
AbstractArticlePDF–2.7M
7.
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome
Pasquelena De Nittis, Stephanie Efthymiou, Alexandre Sarre, Nicolas Guex, Jacqueline Chrast, Audrey Putoux, Tipu Sultan, Javeria Raza Alvi, Zia ur Rahman, Faisal Zafar, Nuzhat Rana, Fatima Rahman, Najwa Anwar, Shazia Maqbool, Maha S Zaki, Joseph G Gleeson, David Murphy, Hamid Galehdari, Gholamreza Shariati, Neda Mazaheri, Alireza Sedaghat, SYNAPS Study Group, Gaetan Lesca, Nicolas Chatron, Vincenzo Salpietro, Marilena Christoforou, Henry Houlden, William F Simonds, Thierry Pedrazzini, Reza Maroofian, Alexandre Reymond
J Med Genet. 2021 Dec; 58(12): 815–831. Published online 2020 Nov 10. doi: 10.1136/jmedgenet-2020-107015
PMCID:
PMC8639930
AbstractArticlePDF–6.3M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses
Swarna Pandian, Jian-Ping Zhao, Yasunobu Murata, Fernando J. Bustos, Cansu Tunca, Ramiro D. Almeida, Martha Constantine-Paton
eNeuro. 2020 Nov-Dec; 7(6): ENEURO.0284-20.2020. Prepublished online 2020 Nov 23. Published online 2020 Dec 15. doi: 10.1523/ENEURO.0284-20.2020
PMCID:
PMC7769881
AbstractArticlePDF–2.6M
10.
The regulatory G protein signaling complex, Gβ5–R7, promotes glucose- and extracellular signal–stimulated insulin secretion
Qiang Wang, Taylor A. N. Henry, Alexey N. Pronin, Geeng-Fu Jang, Camila Lubaczeuski, John W. Crabb, Ernesto Bernal-Mizrachi, Vladlen Z. Slepak
J Biol Chem. 2020 May 22; 295(21): 7213–7223. Published online 2020 Mar 30. doi: 10.1074/jbc.RA119.011534
PMCID:
PMC7247291
AbstractArticlePDF–2.1M
11.
Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice
Claudia M. Krispel, Ching-Kang Chen, Melvin I. Simon, Marie E. Burns
J Neurosci. 2003 Aug 6; 23(18): 6965–6971. doi: 10.1523/JNEUROSCI.23-18-06965.2003
PMCID:
PMC6740649
AbstractArticlePDF–238K
12.
Expression and Localization of RGS9-2/Gβ5/R7BP Complex In Vivo Is Set by Dynamic Control of Its Constitutive Degradation by Cellular Cysteine Proteases
Garret R. Anderson, Rafael Lujan, Arthur Semenov, Marco Pravetoni, Ekaterina N. Posokhova, Joseph H. Song, Vladimir Uversky, Ching-Kang Chen, Kevin Wickman, Kirill A. Martemyanov
J Neurosci. 2007 Dec 19; 27(51): 14117–14127. doi: 10.1523/JNEUROSCI.3884-07.2007
PMCID:
PMC6673529
AbstractArticlePDF–810K
13.
Gβ5 Is Required for Normal Light Responses and Morphology of Retinal ON-Bipolar Cells
Anjali Rao, Rebecca Dallman, Scott Henderson, Ching-Kang Chen
J Neurosci. 2007 Dec 19; 27(51): 14199–14204. doi: 10.1523/JNEUROSCI.4934-07.2007
PMCID:
PMC6673526
AbstractArticlePDF–404K
14.
Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models
Mathilde Soulez, Marc K. Saba-El-Leil, Benjamin Turgeon, Simon Mathien, Philippe Coulombe, Sonia Klinger, Justine Rousseau, Kim Lévesque, Sylvain Meloche
Mol Cell Biol. 2019 Mar 15; 39(6): e00527-18. Prepublished online 2019 Jan 14. Published online 2019 Mar 1. doi: 10.1128/MCB.00527-18
PMCID:
PMC6399666
AbstractArticlePDF–1.1M
15.
Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7
Olga I. Ostrovskaya, Cesare Orlandi, Ana Fajardo-Serrano, Samuel M. Young, Jr., Rafael Lujan, Kirill A. Martemyanov
J Neurosci. 2018 Nov 14; 38(46): 10002–10015. doi: 10.1523/JNEUROSCI.1378-18.2018
PMCID:
PMC6234300
AbstractArticlePDF–4.1M
16.
RNA binding proteins co-localize with small tau inclusions in tauopathy
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
Acta Neuropathol Commun. 2018; 6: 71. Published online 2018 Aug 1. doi: 10.1186/s40478-018-0574-5
PMCID:
PMC6069705
AbstractArticlePDF–5.5M
17.
Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion
Qiang Wang, Alexey N. Pronin, Konstantin Levay, Joana Almaca, Alessia Fornoni, Alejandro Caicedo, Vladlen Z. Slepak
FASEB J. 2017 Nov; 31(11): 4734–4744. Published online 2017 Jul 7. doi: 10.1096/fj.201700197RR
PMCID:
PMC5636707
AbstractArticle
18.
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program
John P. Sundberg, Soheil S. Dadras, Kathleen A. Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N. Schofield, C. Herbert Pratt
PLoS One. 2017; 12(7): e0180682. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180682
PMCID:
PMC5503261
AbstractArticlePDF–31M
19.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
20.
Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex
Carolina Aguado, Cesare Orlandi, Ana Fajardo-Serrano, Mercedes Gil-Minguez, Kirill A. Martemyanov, Rafael Luján
Front Neuroanat. 2016; 10: 114. Published online 2016 Nov 30. doi: 10.3389/fnana.2016.00114
PMCID:
PMC5127842
AbstractArticlePDF–2.1M

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