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Items: 1 to 20 of 47

1.
PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis
Kalliopi Liadaki, Efterpi Zafiriou, Themistoklis Giannoulis, Sofia Alexouda, Kleoniki Chaidaki, Polyxeni Gidarokosta, Angeliki-Viktoria Roussaki-Schulze, Sotirios G. Tsiogkas, Athina Daponte, Zissis Mamuris, Dimitrios P. Bogdanos, Nicholas K. Moschonas, Theologia Sarafidou
Genes (Basel) 2024 Mar; 15(3): 369. Published online 2024 Mar 17. doi: 10.3390/genes15030369
PMCID:
PMC10970167
AbstractArticlePDF–1.0M
2.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
3.
Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins
Amy J. Tibbo, Delphine Mika, Sara Dobi, Jiayue Ling, Aisling McFall, Gonzalo S. Tejeda, Connor Blair, Ruth MacLeod, Niall MacQuaide, Caglar Gök, William Fuller, Brian O. Smith, Godfrey L. Smith, Grégoire Vandecasteele, Thomas Brand, George S. Baillie
J Mol Cell Cardiol. 2022 Apr; 165: 86–102. doi: 10.1016/j.yjmcc.2022.01.001
PMCID:
PMC8986152
AbstractArticlePDF–8.9M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer
Hantao Wang, Junjie Xing, Wei Wang, Guifen Lv, Haiyan He, Yeqing Lu, Mei Sun, Haiyan Chen, Xu Li
Front Cell Dev Biol. 2020; 8: 601502. Published online 2021 Feb 11. doi: 10.3389/fcell.2020.601502
PMCID:
PMC7905040
AbstractArticlePDF–3.2M
6.
Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation
Bernardo Dolce, Torsten Christ, Nefeli Grammatika Pavlidou, Yalin Yildirim, Hermann Reichenspurner, Thomas Eschenhagen, Viacheslav O. Nikolaev, Alberto J Kaumann, Cristina E Molina
Naunyn Schmiedebergs Arch Pharmacol. 2021; 394(2): 291–298. Published online 2020 Sep 19. doi: 10.1007/s00210-020-01968-1
PMCID:
PMC7835186
AbstractArticlePDF–960K
7.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
8.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
9.
Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro
Klaus G. Schmetterer, Katrin Goldhahn, Liesa S. Ziegler, Marlene C. Gerner, Ralf L. J. Schmidt, Madeleine Themanns, Eva Zebedin-Brandl, Doris Trapin, Judith Leitner, Winfried F. Pickl, Peter Steinberger, Ilse Schwarzinger, Rodrig Marculescu
Front Immunol. 2019; 10: 1790. Published online 2019 Jul 30. doi: 10.3389/fimmu.2019.01790
PMCID:
PMC6682678
AbstractArticlePDF–4.0M
10.
PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway
Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang
Anal Cell Pathol (Amst) 2019; 2019: 7145198. Published online 2019 Jan 23. doi: 10.1155/2019/7145198
PMCID:
PMC6364102
AbstractArticlePDF–2.6M
11.
Autophagy induces transforming growth factor‐β‐dependent epithelial‐mesenchymal transition in hepatocarcinoma cells through cAMP response element binding signalling
Shaobo Hu, Liyu Wang, Xi Zhang, Yongzhong Wu, Jing Yang, Jun Li
J Cell Mol Med. 2018 Nov; 22(11): 5518–5532. Published online 2018 Aug 22. doi: 10.1111/jcmm.13825
PMCID:
PMC6201351
AbstractArticlePDF–4.0M
12.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
13.
The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation
Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankel
eLife. 2018; 7: e31879. Published online 2018 May 30. doi: 10.7554/eLife.31879
PMCID:
PMC5999396
AbstractArticlePDF–3.6M
14.
Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress
Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Chen, Jinfeng Xie, Zhongzhen Zhou, Jiangping Xu, Haitao Wang
Redox Biol. 2018 Jun; 16: 47–58. Published online 2018 Feb 14. doi: 10.1016/j.redox.2018.02.008
PMCID:
PMC5842311
AbstractArticlePDF–1.6M
15.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9
PMCID:
PMC5678581
AbstractArticlePDF–3.2M
16.
Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays
Ana Santos de Medeiros, Arlene R. Wyman, Manal A. Alaamery, Christina Allain, F. Douglas Ivey, Lili Wang, Hai Le, James P. Morken, Alawi Habara, Cuong Le, Shuaiying Cui, Adam Lerner, Charles S. Hoffman
Cell Signal. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Cell Signal. 2017 Dec; 40: 73–80. Published online 2017 Sep 1. doi: 10.1016/j.cellsig.2017.08.011
PMCID:
PMC5651194
AbstractArticlePDF–1.0M
17.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
18.
Attenuation of Inhibitory Prostaglandin E2 Signaling in Human Lung Fibroblasts Is Mediated by Phosphodiesterase 4
Joel Michalski, Nobuhiro Kanaji, Xiangde Liu, Steve Nogel, Xingqi Wang, Hesham Basma, Masanori Nakanishi, Tadashi Sato, Yoko Gunji, Maha Fahrid, Amy Nelson, Kai-Christian Muller, Olaf Holz, Helgo Magnussen, Klaus F. Rabe, Myron L. Toews, Stephen I. Rennard
Am J Respir Cell Mol Biol. 2012 Dec; 47(6): 729–737. doi: 10.1165/rcmb.2012-0057OC
PMCID:
PMC5459525
AbstractArticlePDF–631K
19.
Safety and pharmacodynamics of the PDE4 inhibitor roflumilast in advanced B cell malignancies
Kevin Kelly, Alex Mejia, Avvaru Suhasini, An-Ping Lin, John Kuhn, Anand B. Karnad, Steven Weitman, Ricardo C. T. Aguiar
Clin Cancer Res. Author manuscript; available in PMC 2018 Mar 1.
Published in final edited form as: Clin Cancer Res. 2017 Mar 1; 23(5): 1186–1192. Published online 2016 Aug 19. doi: 10.1158/1078-0432.CCR-16-1207
PMCID:
PMC5316514
AbstractArticlePDF–736K
20.
Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners
Kirsty F. Houslay, Frank Christian, Ruth MacLeod, David R. Adams, Miles D. Houslay, George S. Baillie
Biochem J. 2017 Feb 15; 474(4): 597–609. Prepublished online 2016 Dec 19. Published online 2017 Feb 3. doi: 10.1042/BCJ20160849
PMCID:
PMC5290487
AbstractArticlePDF–911K

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