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Items: 1 to 20 of 43

1.
Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse
Chao Song, Arianna Valeri, Fangfang Song, Xing Ji, Xueyang Liao, Tyler Marmo, Rebecca Seeley, Jared Rutter, Fanxin Long
JCI Insight. 2023 Dec 22; 8(24): e174293. Published online 2023 Dec 22. doi: 10.1172/jci.insight.174293
PMCID:
PMC10807709
AbstractArticlePDF–7.7M
2.
Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x
PMCID:
PMC9938216
AbstractArticlePDF–5.3M
3.
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang
Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y
PMCID:
PMC9700781
AbstractArticlePDF–11M
4.
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero
Cell Metab. 2022 May 3; 34(5): 731–746.e9. doi: 10.1016/j.cmet.2022.03.013
PMCID:
PMC9116152
AbstractArticle
5.
Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency
Andres De La Rossa, Marine H Laporte, Simone Astori, Thomas Marissal, Sylvie Montessuit, Preethi Sheshadri, Eva Ramos-Fernández, Pablo Mendez, Abbas Khani, Charles Quairiaux, Eric B Taylor, Jared Rutter, José Manuel Nunes, Alan Carleton, Michael R Duchen, Carmen Sandi, Jean-Claude Martinou
eLife. 2022; 11: e72595. Published online 2022 Feb 21. doi: 10.7554/eLife.72595
PMCID:
PMC8860443
AbstractArticlePDF–3.3M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
The Pyruvate-Lactate Axis Modulates Cardiac Hypertrophy and Heart Failure
Ahmad A. Cluntun, Rachit Badolia, Sandra Lettlova, K. Mark Parnell, Thirupura S. Shankar, Nikolaos A. Diakos, Kristofor A. Olson, Iosif Taleb, Sean M. Tatum, Jordan A. Berg, Corey N. Cunningham, Tyler Van Ry, Alex J. Bott, Aspasia Thodou Krokidi, Sarah Fogarty, Sophia Skedros, Wojciech I. Swiatek, Xuejing Yu, Bai Luo, Shannon Merx, Sutip Navankasattusas, James E. Cox, Gregory S. Ducker, William L. Holland, Stephen H. McKellar, Jared Rutter, Stavros G. Drakos
Cell Metab. Author manuscript; available in PMC 2022 Mar 2.
Published in final edited form as: Cell Metab. 2021 Mar 2; 33(3): 629–648.e10. Published online 2020 Dec 16. doi: 10.1016/j.cmet.2020.12.003
PMCID:
PMC7933116
AbstractArticlePDF–3.1M
8.
Metabolic Reprogramming of Terminally Exhausted CD8+ T cells by IL-10 Enhances Anti-Tumor Immunity
Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Fabien Franco, Mathias Wenes, Imran Siddiqui, Alessio Bevilacqua, Haiping Wang, Hanshuo Yang, Bing Feng, Xin Xie, Catherine M. Sabatel, Benjamin Tschumi, Amphun Chaiboonchoe, Yuxi Wang, Weimin Li, Weihua Xiao, Werner Held, Pedro Romero, Ping-Chih Ho, Li Tang
Nat Immunol. Author manuscript; available in PMC 2021 Nov 24.
Published in final edited form as: Nat Immunol. 2021 Jun 1; 22(6): 746–756. Published online 2021 May 24. doi: 10.1038/s41590-021-00940-2
PMCID:
PMC7610876
AbstractArticlePDF–5.7M
9.
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy
Mariana Fernandez-Caggiano, Alisa Kamynina, Asvi A. Francois, Oleksandra Prysyazhna, Thomas R. Eykyn, Susanne Krasemann, Maria G. Crespo-Leiro, Maria Garcia Vieites, Katiuscia Bianchi, Valle Morales, Nieves Domenech, Philip Eaton
Nat Metab. Author manuscript; available in PMC 2021 Mar 23.
Published in final edited form as: Nat Metab. 2020 Nov 1; 2(11): 1223–1231. Published online 2020 Oct 26. doi: 10.1038/s42255-020-00276-5
PMCID:
PMC7610404
AbstractArticlePDF–3.5M
10.
T cell-expressed microRNA-155 reduces lifespan in a mouse model of age-related chronic inflammation
H. Atakan Ekiz, Andrew G. Ramstead, Soh-Hyun Lee, Morgan C. Nelson, Kaylyn M. Bauer, Jared A. Wallace, Ruozhen Hu, June L. Round, Jared Rutter, Micah J. Drummond, Dinesh S. Rao, Ryan M. O’Connell
J Immunol. Author manuscript; available in PMC 2021 Apr 15.
Published in final edited form as: J Immunol. 2020 Apr 15; 204(8): 2064–2075. Published online 2020 Mar 11. doi: 10.4049/jimmunol.1901484
PMCID:
PMC7325601
AbstractArticlePDF–2.3M
11.
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant
Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely
Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089
PMCID:
PMC7295033
AbstractArticlePDF–2.7M
12.
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss
Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs
Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931
PMCID:
PMC7227028
AbstractArticlePDF–5.4M
13.
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Cell Rep. Author manuscript; available in PMC 2020 Apr 20.
Published in final edited form as: Cell Rep. 2020 Mar 3; 30(9): 2889–2899.e6. doi: 10.1016/j.celrep.2020.02.042
PMCID:
PMC7170217
AbstractArticlePDF–2.1M
14.
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier
Claire L. Bensard, Dona R. Wisidagama, Kristofor A. Olson, Jordan A. Berg, Nathan M. Krah, John C. Schell, Sara M. Nowinski, Sarah Fogarty, Alex J. Bott, Peng Wei, Katja K. Dove, Jason M. Tanner, Vanja Panic, Ahmad Cluntun, Sandra Lettlova, Christian S. Earl, David F. Namnath, Karina Vázquez-Arregun, Claudio J. Villanueva, Dean Tantin, L. Charles Murtaugh, Kimberley J. Evason, Gregory S. Ducker, Carl S. Thummel, Jared Rutter
Cell Metab. Author manuscript; available in PMC 2021 Feb 4.
Published in final edited form as: Cell Metab. 2020 Feb 4; 31(2): 284–300.e7. Published online 2019 Dec 5. doi: 10.1016/j.cmet.2019.11.002
PMCID:
PMC7004878
AbstractArticlePDF–3.7M
15.
Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress
Caitlyn E. Bowman, Ebru S. Selen Alpergin, Kyle Cavagnini, Danielle M. Smith, Susanna Scafidi, Michael J. Wolfgang
Cell Rep. Author manuscript; available in PMC 2019 Dec 6.
Published in final edited form as: Cell Rep. 2019 Oct 29; 29(5): 1299–1310.e3. doi: 10.1016/j.celrep.2019.09.053
PMCID:
PMC6896898
AbstractArticlePDF–2.7M
16.
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis
Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor
Cell Rep. Author manuscript; available in PMC 2019 Sep 16.
Published in final edited form as: Cell Rep. 2019 Sep 3; 28(10): 2608–2619.e6. doi: 10.1016/j.celrep.2019.07.098
PMCID:
PMC6746334
AbstractArticlePDF–2.3M
17.
Loss of MPC1 reprograms retinal metabolism to impair visual function
Allison Grenell, Yekai Wang, Michelle Yam, Aditi Swarup, Tanya L. Dilan, Allison Hauer, Jonathan D. Linton, Nancy J. Philp, Elizabeth Gregor, Siyan Zhu, Quan Shi, Joseph Murphy, Tongju Guan, Daniel Lohner, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Andrew F. X. Goldberg, James B. Hurley, Jianhai Du
Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3530–3535. Published online 2019 Feb 11. doi: 10.1073/pnas.1812941116
PMCID:
PMC6397593
AbstractArticlePDF–1.4M
18.
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity
Katharina Timper, Lars Paeger, Carmen Sánchez-Lasheras, Luis Varela, Alexander Jais, Hendrik Nolte, Merly C. Vogt, A. Christine Hausen, Christian Heilinger, Nadine Evers, J. Andrew Pospisilik, Josef M. Penninger, Eric B. Taylor, Tamas L. Horvath, Peter Kloppenburg, Jens Claus Brüning
Cell Rep. Author manuscript; available in PMC 2019 Jan 28.
Published in final edited form as: Cell Rep. 2018 Oct 9; 25(2): 383–397.e10. doi: 10.1016/j.celrep.2018.09.034
PMCID:
PMC6349418
AbstractArticlePDF–3.3M
19.
Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II–driven respiration
Brian D. Fink, Fan Bai, Liping Yu, Ryan D. Sheldon, Arpit Sharma, Eric B. Taylor, William I. Sivitz
J Biol Chem. 2018 Dec 21; 293(51): 19932–19941. Published online 2018 Nov 1. doi: 10.1074/jbc.RA118.005144
PMCID:
PMC6314144
AbstractArticlePDF–1.6M
20.
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei, Jason Tanner, Aimee Flores, Jeffrey Mohlman, Lise K. Sorensen, Christian S. Earl, Kristofor A. Olson, Ren Miao, T. Cameron Waller, Don Delker, Priyanka Kanth, Lei Jiang, Ralph J. DeBerardinis, Mary P. Bronner, Dean Y. Li, James E. Cox, Heather R. Christofk, William E. Lowry, Carl S. Thummel, Jared Rutter
Nat Cell Biol. Author manuscript; available in PMC 2018 Sep 14.
Published in final edited form as: Nat Cell Biol. 2017 Sep; 19(9): 1027–1036. Published online 2017 Aug 14. doi: 10.1038/ncb3593
PMCID:
PMC6137334
AbstractArticlePDF–4.7M

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