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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 110732882.

SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction

Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi

Cell Mol Life Sci. 2023 Dec; 80(12): 364. Published online 2023 Nov 20. doi: 10.1007/s00018-023-05011-3

PMCID:: PMC11073288

Abstract Article PDF–5.3M

Select item 110499483.

Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus

Jiehan Chen, Qiaowen Wang, Biying Zhong, Huiying Zheng, Dingjun Wang, Xiao Huang, Li Liu, Tiantian Liu

Int J Mol Sci. 2024 Apr; 25(8): 4178. Published online 2024 Apr 10. doi: 10.3390/ijms25084178

PMCID:: PMC11049948

Abstract Article PDF–7.3M

Select item 108544314.

MAVI1, an endoplasmic reticulum–localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion

Tao-tao Shi, Ying Huang, Ying Li, Xiang-long Dai, Yao-hui He, Jian-cheng Ding, Ting Ran, Yang Shi, Quan Yuan, Wen-juan Li, Wen Liu

Sci Adv. 2023 Sep; 9(35): eadg7053. Published online 2023 Sep 1. doi: 10.1126/sciadv.adg7053

PMCID:: PMC10854431

Abstract Article PDF–2.1M

Select item 107473965.

The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation

Congcong Huang, Yiping Yin, Pan Pan, Yanping Huang, Siwei Chen, Junkai Chen, Ju Wang, Guoqing Xu, Xuan Tao, Xiao Xiao, Jian Li, Jing Yang, Zhixiong Jin, Bei Li, Zhaohui Tong, Weixing Du, Long Liu, Zhixin Liu

Viruses. 2023 Dec; 15(12): 2304. Published online 2023 Nov 24. doi: 10.3390/v15122304

PMCID:: PMC10747396

Abstract Article PDF–3.5M

Select item 107028366.

ORF3c is expressed in SARS‐CoV‐2‐infected cells and inhibits innate sensing by targeting MAVS

Martin Müller, Alexandra Herrmann, Shigeru Fujita, Keiya Uriu, Carolin Kruth, Adam Strange, Jan E Kolberg, Markus Schneider, Jumpei Ito, Marcel A Müller, Christian Drosten, Armin Ensser, The Genotype to Phenotype Japan (G2P‐Japan) Consortium, Kei Sato, Daniel Sauter

EMBO Rep. 2023 Dec; 24(12): e57137. Published online 2023 Oct 23. doi: 10.15252/embr.202357137

PMCID:: PMC10702836

Abstract Article PDF–2.7M

Select item 106415247.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 104006198.

MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation

Maria G. Noval, Sophie N. Spector, Eric Bartnicki, Franco Izzo, Navneet Narula, Stephen T. Yeung, Payal Damani-Yokota, M. Zahidunnabi Dewan, Valeria Mezzano, Bruno A. Rodriguez-Rodriguez, Cynthia Loomis, Kamal M. Khanna, Kenneth A. Stapleford

Nat Commun. 2023; 14: 4668. Published online 2023 Aug 3. doi: 10.1038/s41467-023-40047-w

PMCID:: PMC10400619

Abstract Article PDF–5.1M

Select item 103338849.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

Select item 1032325210.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 1028964811.

VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation

Zhiqiang Hu, Yingchao Xie, Jiansen Lu, Jianwu Yang, Jiahuan Zhang, Huaji Jiang, Hongyu Li, Yufeng Zhang, Dan Wu, Ke Zeng, Xiaochun Bai, Xiao Yu

Sci Adv. 2023 Jun; 9(25): eadg2339. Published online 2023 Jun 23. doi: 10.1126/sciadv.adg2339

PMCID:: PMC10289648

Abstract Article PDF–2.6M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1023616413.

Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response

Ying Nie, Dongqing Deng, Lumin Mou, Qizhou Long, Jinzhi Chen, Jiahong Wu

J Microbiol Biotechnol. 2023 May 28; 33(5): 600–606. Published online 2023 Feb 15. doi: 10.4014/jmb.2210.10006

PMCID:: PMC10236164

Abstract Article PDF–1.4M

Select item 1018381814.

CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS

Jia Yi, Lei Wang, Guo‐sheng Hu, Yue‐ying Zhang, Jiao Du, Jian‐cheng Ding, Xiang Ji, Hai‐feng Shen, Hai‐hua Huang, Feng Ye, Wen Liu

EMBO J. 2023 May; 42(10): e112408. Published online 2023 Apr 3. doi: 10.15252/embj.2022112408

PMCID:: PMC10183818

Abstract Article PDF–5.2M

Select item 1016526915.

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination

Ya-Yun Chen, Xiang-Hong Ran, Run-Ze Ni, Dan Mu

J Biol Chem. 2023 May; 299(5): 104660. Published online 2023 Apr 27. doi: 10.1016/j.jbc.2023.104660

PMCID:: PMC10165269

Abstract Article PDF–2.8M

Select item 985197316.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0