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Items: 1 to 20 of 31

1.
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer
Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek
Nat Commun. 2024; 15: 5266. Published online 2024 Jun 20. doi: 10.1038/s41467-024-49450-3
PMCID:
PMC11189927
AbstractArticlePDF–2.3M
2.
Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis
Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao
Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9
Correction in:
Nat Commun. 2024; 15: 4936.
PMCID:
PMC11096176
AbstractArticlePDF–5.7M
3.
Downregulation of Ubiquitin-Specific Protease 15 (USP15) Does Not Provide Therapeutic Benefit in Experimental Mesial Temporal Lobe Epilepsy
Ute Häussler, João Neres, Catherine Vandenplas, Caroline Eykens, Irena Kadiu, Carolin Schramm, Renaud Fleurance, Phil Stanley, Patrice Godard, Laurane de Mot, Jonathan van Eyll, Klaus-Peter Knobeloch, Carola A. Haas, Stefanie Dedeurwaerdere
Mol Neurobiol. 2024; 61(4): 2367–2389. Published online 2023 Oct 24. doi: 10.1007/s12035-023-03692-2
PMCID:
PMC10973041
AbstractArticlePDF–11M
4.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
5.
Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Jung-Hwan Baek, Myung Sup Kim, Hye Ryeon Jung, Min-Seon Hwang, Chan-ho Lee, Dai Hoon Han, Yong-ho Lee, Eugene C. Yi, Seung-Soon Im, Ilseon Hwang, Kyungeun Kim, Joon-Yong Chung, Kyung-Hee Chun
Exp Mol Med. 2023 Jul; 55(7): 1520–1530. Published online 2023 Jul 3. doi: 10.1038/s12276-023-01036-7
Correction in:
Exp Mol Med. 2024 Oct; 56(10): 2324.
PMCID:
PMC10394025
AbstractArticlePDF–7.6M
6.
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner
Zhuhua Wu, Li Zhu, Xinran Nie, Li Wei, Yong Qi
Exp Mol Med. 2023 Jan; 55(1): 183–195. Published online 2023 Jan 12. doi: 10.1038/s12276-022-00920-y
PMCID:
PMC9898287
AbstractArticlePDF–7.1M
7.
SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15
Lei Li, Jialiang Luo, Zhengyumeng Zhu, Qishan Xu, Ping Wang, Bo Chang, Di Wang, Lu Yu, Xiao Lu, Jia Zhou, Daming Zuo, Qingyun Chen
Microbiol Spectr. 2022 Nov-Dec; 10(6): e02028-22. Published online 2022 Nov 7. doi: 10.1128/spectrum.02028-22
PMCID:
PMC9769732
AbstractArticlePDF–4.3M
8.
USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion
Xinyao Tian, Yan Zhao, Zhe Yang, Qianrang Lu, Lin Zhou, Shusen Zheng
Cell Death Dis. 2022 Sep; 13(9): 823. Published online 2022 Sep 26. doi: 10.1038/s41419-022-05277-8
PMCID:
PMC9512921
AbstractArticlePDF–5.4M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells
Paul van den Berk, Cesare Lancini, Carlos Company, Michela Serresi, Maria Pilar Sanchez-Bailon, Danielle Hulsman, Colin Pritchard, Ji-Ying Song, Matthias Jürgen Schmitt, Ellen Tanger, Oliver Popp, Philipp Mertins, Ivo J. Huijbers, Heinz Jacobs, Maarten van Lohuizen, Gaetano Gargiulo, Elisabetta Citterio
Cell Rep. 2020 Dec 29; 33(13): 108533. Published online 2020 Dec 29. doi: 10.1016/j.celrep.2020.108533
PMCID:
PMC7788286
AbstractArticle
11.
USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis
Jaehyun Kim, Junnosuke Nakamura, Chiharu Hamada, Takumi Taketomi, Sarasa Yano, Tomomi Okajima, Shin-ichi Kashiwabara, Tadashi Baba, Ban Sato, Tomoki Chiba, Fuminori Tsuruta
Mol Cell Biol. 2020 Nov; 40(21): e00098-20. Prepublished online 2020 Aug 24. Published online 2020 Oct 13. doi: 10.1128/MCB.00098-20
PMCID:
PMC7556847
AbstractArticlePDF–3.9M
12.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
13.
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis
Madeline Niederkorn, Kathleen Hueneman, Kwangmin Choi, Melinda E. Varney, Laurel Romano, Mario A. Pujato, Kenneth D. Greis, Jun-ichiro Inoue, Ruhikanta Meetei, Daniel T. Starczynowski
Cell Rep. Author manuscript; available in PMC 2020 Jul 27.
Published in final edited form as: Cell Rep. 2020 Feb 25; 30(8): 2776–2790.e6. doi: 10.1016/j.celrep.2020.01.093
PMCID:
PMC7384867
AbstractArticlePDF–2.2M
14.
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
Yihan Peng, Qingchao Liao, Wei Tan, Changmin Peng, Zhaohua Hu, Yali Chen, Zhuqing Li, Jing Li, Bei Zhen, Wenge Zhu, Xiangpan Li, Yi Yao, Qibin Song, Chengsheng Liu, Xiangdong Qi, Fuchu He, Huadong Pei
Nat Commun. 2019; 10: 1224. Published online 2019 Mar 15. doi: 10.1038/s41467-019-09232-8
PMCID:
PMC6420636
AbstractArticlePDF–3.9M
15.
USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-κBp65
Lili Zhou, Hua Jiang, Juan Du, Lu Li, Rong Li, Jing Lu, Weijun Fu, Jian Hou
Exp Mol Med. 2018 Nov; 50(11): 151. Published online 2018 Nov 20. doi: 10.1038/s12276-018-0180-4
PMCID:
PMC6244212
AbstractArticlePDF–2.5M
16.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
17.
T cell intrinsic USP15 deficiency promotes excessive IFN-γ production and an immunosuppressive tumor microenvironment in MCA-induced fibrosarcoma
Qiang Zou, Jin Jin, Yichuan Xiao, Xiaofei Zhou, Hongbo Hu, Xuhong Cheng, Nasser Kazimi, Stephen E Ullrich, Shao-Cong Sun
Cell Rep. Author manuscript; available in PMC 2016 Jan 8.
Published in final edited form as: Cell Rep. 2015 Dec 22; 13(11): 2470–2479. Published online 2015 Dec 10. doi: 10.1016/j.celrep.2015.11.046
PMCID:
PMC4691552
AbstractArticlePDF–1.7M
18.
Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11
Caitlyn Vlasschaert, Xuhua Xia, Josée Coulombe, Douglas A. Gray
BMC Evol Biol. 2015; 15: 230. Published online 2015 Oct 26. doi: 10.1186/s12862-015-0511-1
PMCID:
PMC4624187
AbstractArticlePDF–3.0M
19.
USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling
Lina Herhaus, Mazin A. Al-Salihi, Kevin S. Dingwell, Timothy D. Cummins, Lize Wasmus, Janis Vogt, Richard Ewan, David Bruce, Thomas Macartney, Simone Weidlich, James C. Smith, Gopal P. Sapkota
Open Biol. 2014 May; 4(5): 140065. Published online 2014 May 21. doi: 10.1098/rsob.140065
PMCID:
PMC4042855
AbstractArticlePDF–1015K
20.
USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T cell responses
Qiang Zou, Jin Jin, Hongbo Hu, Haiyan S. Li, Simona Romano, Yichuan Xiao, Mako Nakaya, Xiaofei Zhou, Xuhong Cheng, Peirong Yang, Guillermina Lozano, Chengming Zhu, Stephanie S. Watowich, Stephen E Ullrich, Shao-Cong Sun
Nat Immunol. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: Nat Immunol. 2014 Jun; 15(6): 562–570. Published online 2014 Apr 28. doi: 10.1038/ni.2885
PMCID:
PMC4032322
AbstractArticlePDF–6.0M

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