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Select item 112969141.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111227193.

Uterine Leiomyomas with Specific Histology Features of Two Fumarate Hydratase/Succinate Dehydrogenase-Deficient Tumors: A Double Case Report

Ljubiša Jovanović, Svetlana Milenković, Luka Andrić, Radomir Stefanović, Branislav Milošević, Jelena Micić, Igor Pilić, Aleksandra Beleslin, Olga Mihaljević, Milan Dokić

Medicina (Kaunas) 2024 May; 60(5): 825. Published online 2024 May 17. doi: 10.3390/medicina60050825

PMCID:: PMC11122719

Abstract Article PDF–2.2M

Select item 106302464.

Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of Hereditary Leiomyomatosis and Renal Cell Cancer

Daniel R Crooks, Geetha Mariah Cawthon, Christina M Fitzsimmons, Minervo Perez, Christopher J Ricketts, Cathy D Vocke, Ye Yang, Lindsay Middelton, Debbie Nielsen, Laura S Schmidt, Mayank Tandon, Maria J Merino, Mark W Ball, Jordan L Meier, Pedro J Batista, William Marston Linehan

Hum Mol Genet. 2023 Nov 15; 32(22): 3135–3145. Published online 2023 Aug 10. doi: 10.1093/hmg/ddad131

PMCID:: PMC10630246

Abstract Article PDF–1.5M

Select item 105276005.

FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer

Blake R. Wilde, Nishma Chakraborty, Nedas Matulionis, Stephanie Hernandez, Daiki Ueno, Michayla E. Gee, Edward D. Esplin, Karen Ouyang, Keith Nykamp, Brian Shuch, Heather R. Christofk

Cancer Discov. Author manuscript; available in PMC 2024 Mar 6.

Published in final edited form as: Cancer Discov. 2023 Sep 6; 13(9): 2072–2089. doi: 10.1158/2159-8290.CD-22-0874

PMCID:: PMC10527600

Abstract Article PDF–2.4M

Select item 104404756.

Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells

Song Jiao, Pablo Miranda, Yan Li, Dragan Maric, Miguel Holmgren

Heliyon. 2023 Aug; 9(8): e18754. Published online 2023 Aug 1. doi: 10.1016/j.heliyon.2023.e18754

PMCID:: PMC10440475

Abstract Article PDF–8.9M

Select item 104113007.

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A. J. Ryan, Alfonso Bolado-Carrancio, Alva M. Casey, Hiran A. Prag, Ana S. H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alexander Von Kriegsheim, Michael P. Murphy, Caroline Jefferies, Christian Frezza, Luke A. J. O’Neill

Nature. Author manuscript; available in PMC 2023 Aug 9.

Published in final edited form as: Nature. 2023 Mar; 615(7952): 490–498. Published online 2023 Mar 8. doi: 10.1038/s41586-019-0000-0

PMCID:: PMC10411300

Abstract Article PDF–5.8M

Select item 103166758.

Estimation of the Carrier Frequency of Fumarate Hydratase Alterations and Implications for Kidney Cancer Risk in Hereditary Leiomyomatosis and Renal Cancer

Brian Shuch, Shantao Li, Harvey Risch, Ranjit S. Bindra, Patrick D. McGillivray, Mark Gerstein

Cancer. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Cancer. 2020 Aug 15; 126(16): 3657–3666. Published online 2020 May 15. doi: 10.1002/cncr.32914

PMCID:: PMC10316675

Abstract Article PDF–759K

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1020218310.

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan

Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091

PMCID:: PMC10202183

Abstract Article PDF–18M

Select item 1011228111.

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

François Le Guerroué, Eric N Bunker, William M Rosencrans, Jack T Nguyen, Mohammed A Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J Youle

Mol Cell. Author manuscript; available in PMC 2024 Mar 16.

Published in final edited form as: Mol Cell. 2023 Mar 16; 83(6): 927–941.e8. Published online 2023 Mar 9. doi: 10.1016/j.molcel.2023.02.023

PMCID:: PMC10112281

Abstract Article PDF–2.4M

Select item 1004820312.

A Missense Mutation c.1132G > A in Fumarate Hydratase (FH) Leads to Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome and Insights into Clinical Management in Uterine Leiomyomata

Yue Shi, Yan Xu, Chao Wang, Yiqing Chen, Xiaojun Ren, Yu Kang, Chao Wang

Genes (Basel) 2023 Mar; 14(3): 744. Published online 2023 Mar 18. doi: 10.3390/genes14030744

PMCID:: PMC10048203

Abstract Article PDF–5.1M

Select item 962912113.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 955026614.

Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition

Ilaria Iacobucci, Vittoria Monaco, Luisa Canè, Francesca Bibbò, Valentina Cioffi, Flora Cozzolino, Alfredo Guarino, Massimo Zollo, Maria Monti

Front Mol Biosci. 2022; 9: 975570. Published online 2022 Sep 26. doi: 10.3389/fmolb.2022.975570

PMCID:: PMC9550266

Abstract Article PDF–2.5M

Select item 946426615.

Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas

Angela Yoo, Cerise Tang, Mark Zucker, Kelly Fitzgerald, Renzo G. DiNatale, Phillip M. Rappold, Kate Weiss, Benjamin Freeman, Chung-Han Lee, Nikolaus Schultz, Robert Motzer, Paul Russo, Jonathan Coleman, Victor E. Reuter, Ying-Bei Chen, Maria I. Carlo, Anthony J. Gill, Ritesh R. Kotecha, A. Ari Hakimi, Ed Reznik

Eur Urol Focus. Author manuscript; available in PMC 2022 Dec 6.

Published in final edited form as: Eur Urol Focus. 2022 Sep; 8(5): 1278–1288. Published online 2022 Mar 11. doi: 10.1016/j.euf.2021.12.002

PMCID:: PMC9464266

Abstract Article PDF–1.4M

Select item 927116816.

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways

David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, Issam Ben-Sahra, Daniel R. Foltz, Jian Li, Marc L. Mendillo

Proc Natl Acad Sci U S A. 2022 Jul 5; 119(27): e2111262119. Published online 2022 Jul 1. doi: 10.1073/pnas.2111262119

PMCID:: PMC9271168

Abstract Article PDF–2.6M

Select item 917026817.

Fumarate Hydratase Variant Prevalence and Manifestations Among Individuals Receiving Germline Testing

Eric Lu, Kathryn E. Hatchell, Sarah M. Nielsen, Edward D. Esplin, Karen Ouyang, Keith Nykamp, Shirin Zavoshi, Shantao Li, Liying Zhang, Blake R. Wilde, Heather R. Christofk, Paul C. Boutros, Brian Shuch

Cancer. Author manuscript; available in PMC 2022 Jun 6.

Published in final edited form as: Cancer. 2022 Feb 15; 128(4): 675–684. Published online 2021 Nov 1. doi: 10.1002/cncr.33997

PMCID:: PMC9170268

Abstract Article PDF–702K

Select item 911688118.

Clues to Recognition of Fumarate Hydratase-Deficient Renal Cell Carcinoma: Findings From Cytologic and Limited Biopsy Samples

Irene Shyu, Leili Mirsadraei, Xiaoyan Wang, Valentina Robila, Rohit Mehra, Jonathan B. McHugh, Ying-Bei Chen, Aaron M. Udager, Anthony J. Gill, Liang Cheng, Mahul B. Amin, Oscar Lin, Steven Christopher Smith

Cancer Cytopathol. Author manuscript; available in PMC 2022 May 18.

Published in final edited form as: Cancer Cytopathol. 2018 Dec; 126(12): 992–1002. Published online 2018 Oct 19. doi: 10.1002/cncy.22071

PMCID:: PMC9116881

Abstract Article PDF–2.9M

Select item 910630319.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 905883620.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

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