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Select item 112608531.

ACLY alternative splicing correlates with cancer phenotypes

Julianna G. Supplee, Hayley C. Affronti, Richard Duan, Rebekah C. Brooks, Zachary E. Stine, Phuong T.T. Nguyen, Laura V. Pinheiro, Michael C. Noji, Jack M. Drummond, Kevin Huang, Kollin Schultz, Chi V. Dang, Ronen Marmorstein, Kathryn E. Wellen

J Biol Chem. 2024 Jul; 300(7): 107418. Published online 2024 May 28. doi: 10.1016/j.jbc.2024.107418

PMCID:: PMC11260853

Abstract Article PDF–4.1M

Select item 106763602.

Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance

Fabiola Diniz, Nguyen Yen Nhi Ngo, Mariel Colon-Leyva, Francesca Edgington-Giordano, Sylvia Hilliard, Kevin Zwezdaryk, Jiao Liu, Samir S. El-Dahr, Giovane G. Tortelote

Nat Commun. 2023; 14: 7733. Published online 2023 Nov 25. doi: 10.1038/s41467-023-43513-7

PMCID:: PMC10676360

Abstract Article PDF–12M

Select item 105509953.

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou

Nat Commun. 2023; 14: 6201. Published online 2023 Oct 4. doi: 10.1038/s41467-023-41757-x

Correction in:: Nat Commun. 2024; 15: 7167.

PMCID:: PMC10550995

Abstract Article PDF–3.0M

Select item 102861054.

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech

Cell Rep. Author manuscript; available in PMC 2023 Jun 22.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112488. Published online 2023 May 8. doi: 10.1016/j.celrep.2023.112488

PMCID:: PMC10286105

Abstract Article PDF–3.3M

Select item 96038605.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 94905926.

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

Batuhan Yenilmez, Mark Kelly, Guo-Fang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, Jason K. Kim, Guangping Gao, Mark A. Herman, Christopher B. Newgard, Michael P. Czech

J Biol Chem. 2022 Oct; 298(10): 102401. Published online 2022 Aug 18. doi: 10.1016/j.jbc.2022.102401

PMCID:: PMC9490592

Abstract Article PDF–1.6M

Select item 94819337.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93864648.

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation

Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang

Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548

PMCID:: PMC9386464

Abstract Article PDF–6.6M

Select item 90190659.

The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming

Sophia M. Hochrein, Hao Wu, Miriam Eckstein, Laura Arrigoni, Josip S. Herman, Fabian Schumacher, Christian Gerecke, Mathias Rosenfeldt, Dominic Grün, Burkhard Kleuser, Georg Gasteiger, Wolfgang Kastenmüller, Bart Ghesquière, Jan Van den Bossche, E. Dale Abel, Martin Vaeth

Cell Metab. Author manuscript; available in PMC 2023 Apr 5.

Published in final edited form as: Cell Metab. 2022 Apr 5; 34(4): 516–532.e11. Published online 2022 Mar 21. doi: 10.1016/j.cmet.2022.02.015

PMCID:: PMC9019065

Abstract Article PDF–1.8M

Select item 883246110.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 877727611.

PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway

Nianyin Lv, Sufeng Jin, Zihao Liang, Xiaohui Wu, Yanhua Kang, Lan Su, Yeping Dong, Bingwei Wang, Tonghui Ma, Liyun Shi

Front Immunol. 2021; 12: 751409. Published online 2022 Jan 7. doi: 10.3389/fimmu.2021.751409

PMCID:: PMC8777276

Abstract Article PDF–10M

Select item 858931612.

Lactate supports a metabolic-epigenetic link in macrophage polarization

Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, Lindsey R. Conroy, Samantha M. Morrissey, Lyndsay E.A. Young, Ronald C. Bruntz, Eun J. Kim, Ashley Wise-Mitchell, Mariana Barbosa de Souza Rizzo, Eric R. Relich, Becca V. Baby, Lance A. Johnson, Hayley C. Affronti, Kelly M. McMasters, Brian F. Clem, Matthew S. Gentry, Jun Yan, Kathryn E. Wellen, Ramon C. Sun, Robert A. Mitchell

Sci Adv. 2021 Nov; 7(46): eabi8602. Published online 2021 Nov 12. doi: 10.1126/sciadv.abi8602

PMCID:: PMC8589316

Abstract Article PDF–2.6M

Select item 849760613.

ATP-citrate lyase promotes axonal transport across species

Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail, Sophie Laguesse, Nathalie Krusy, Ariel Brisker, Alexander Brandis, Shani Inbar, Alain Chariot, Frédéric Saudou, Paula Dietrich, Ioannis Dragatsis, Bert Brone, Loïc Broix, Jean-Michel Rigo, Miguel Weil, Laurent Nguyen

Nat Commun. 2021; 12: 5878. Published online 2021 Oct 7. doi: 10.1038/s41467-021-25786-y

Correction in:: Nat Commun. 2021; 12: 6678.

PMCID:: PMC8497606

Abstract Article PDF–5.3M

Select item 831323914.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 816268615.

PEG3 controls lipogenesis through ACLY

Subash Ghimire, Joomyeong Kim

PLoS One. 2021; 16(5): e0252354. Published online 2021 May 28. doi: 10.1371/journal.pone.0252354

PMCID:: PMC8162686

Abstract Article PDF–2.3M

Select item 810772216.

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche

Front Immunol. 2021; 12: 669920. Published online 2021 Apr 26. doi: 10.3389/fimmu.2021.669920

PMCID:: PMC8107722

Abstract Article PDF–7.9M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 754139118.

FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes

Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Hiroki Shima, Ryo Ito, Ryo Zama, Ariful Islam, Shin-ichiro Kanno, Akira Yasui, Shun Sato, Kosuke Jozaki, Subrata Kumar Shil, Hirofumi Miyazaki, Shuhei Kobayashi, Yui Yamamoto, Hiroshi Kogo, Chie Shimamoto-Mitsuyama, Akira Sugawara, Norihiro Sugino, Masayuki Kanamori, Teiji Tominaga, Takeo Yoshikawa, Kohji Fukunaga, Kazuhiko Igarashi, Yuji Owada

Mol Neurobiol. 2020; 57(12): 4891–4910. Published online 2020 Aug 19. doi: 10.1007/s12035-020-02057-3

PMCID:: PMC7541391

Abstract Article PDF–2.4M

Select item 741651619.

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Steven Zhao, Cholsoon Jang, Joyce Liu, Kahealani Uehara, Michael Gilbert, Luke Izzo, Xianfeng Zeng, Sophie Trefely, Sully Fernandez, Alessandro Carrer, Katelyn D. Miller, Zachary T. Schug, Nathaniel W. Snyder, Terence P. Gade, Paul M. Titchenell, Joshua D. Rabinowitz, Kathryn E. Wellen

Nature. Author manuscript; available in PMC 2020 Sep 18.

Published in final edited form as: Nature. 2020 Mar; 579(7800): 586–591. Published online 2020 Mar 18. doi: 10.1038/s41586-020-2101-7

PMCID:: PMC7416516

Abstract Article PDF–6.1M

Select item 741599120.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

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