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Select item 107177461.

Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population

Zhi-Jun Sun, Yan Li, Jing-Yu Lu, Qian Ding, Yu Liang, Jing-Pu Shi, Jesse Li-Ling, Yan-Yan Zhao

J Physiol Sci. 2009 Mar; 59(2): 81–86. Published online 2008 Dec 17. doi: 10.1007/s12576-008-0011-9

PMCID:: PMC10717746

Abstract Article PDF–231K

Select item 103626902.

KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway

Siqi Ying, Qin Guo, Chong Zhang

BMC Nephrol. 2023; 24: 217. Published online 2023 Jul 22. doi: 10.1186/s12882-023-03257-4

PMCID:: PMC10362690

Abstract Article PDF–2.6M

Select item 99224683.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 90560264.

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis

Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2022 Apr 30.

Published in final edited form as: Anal Chem. 2022 Mar 15; 94(10): 4236–4242. Published online 2022 Mar 2. doi: 10.1021/acs.analchem.1c04485

PMCID:: PMC9056026

Abstract Article PDF–1.0M

Select item 87690725.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 86671866.

A Novel CUL3 Variant causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase activity

Harish E. Chatrathi, Jason C. Collins, Lynne A. Wolfe, Thomas C. Markello, David R. Adams, William A. Gahl, Achim Werner, Prashant Sharma

Hypertension. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Hypertension. 2022 Jan; 79(1): 60–75. Published online 2021 Dec 2. doi: 10.1161/HYPERTENSIONAHA.121.17624

PMCID:: PMC8667186

Abstract Article PDF–1.6M

Select item 76652147.

WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID

Atsushi Sato, Masahiro Shimizu, Toshiyasu Goto, Hiroyuki Masuno, Hiroyuki Kagechika, Nobuyuki Tanaka, Hiroshi Shibuya

Commun Biol. 2020; 3: 666. Published online 2020 Nov 12. doi: 10.1038/s42003-020-01386-2

PMCID:: PMC7665214

Abstract Article PDF–2.6M

Select item 68957938.

Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications

Aida Barreiro-Alonso, María Cámara-Quílez, Martín Salamini-Montemurri, Mónica Lamas-Maceiras, Ángel Vizoso-Vázquez, Esther Rodríguez-Belmonte, María Quindós-Varela, Olaia Martínez-Iglesias, Angélica Figueroa, María-Esperanza Cerdán

Cancers (Basel) 2019 Nov; 11(11): 1729. Published online 2019 Nov 5. doi: 10.3390/cancers11111729

PMCID:: PMC6895793

Abstract Article PDF–3.1M

Select item 66886139.

Unveiling the distinct mechanisms by which disease-causing mutations in the Kelch domain of KLHL3 disrupt the interaction with the acidic motif of WNK4 through molecular dynamics simulation

Lingyun Wang, Chen Jiang, Ruiqi Cai, Xing-Zhen Chen, Ji-Bin Peng

Biochemistry. Author manuscript; available in PMC 2020 Apr 23.

Published in final edited form as: Biochemistry. 2019 Apr 23; 58(16): 2105–2115. Published online 2019 Apr 10. doi: 10.1021/acs.biochem.9b00066

PMCID:: PMC6688613

Abstract Article PDF–1.2M

Select item 656554510.

A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4

Takashi Sakoh, Akinari Sekine, Takayasu Mori, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Noriko Hayami, Masayuki Yamanouchi, Tatsuya Suwabe, Naoki Sawa, Yoshifumi Ubara, Takuya Fujimaru, Eisei Sohara, Uchida Shinichi, Junichi Hoshino, Kenmei Takaichi

Mol Genet Genomic Med. 2019 Jun; 7(6): e705. Published online 2019 May 1. doi: 10.1002/mgg3.705

PMCID:: PMC6565545

Abstract Article PDF–311K

Select item 638666111.

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling

Kenichi Ishizawa, Qin Wang, Jinping Li, Osamu Yamazaki, Yoshifuru Tamura, Yoshihide Fujigaki, Shunya Uchida, Richard P. Lifton, Shigeru Shibata

Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8): 3155–3160. Published online 2019 Feb 4. doi: 10.1073/pnas.1817281116

PMCID:: PMC6386661

Abstract Article PDF–1.1M

Select item 617258012.

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC

Eduardo R. Argaiz, Maria Chavez-Canales, Mauricio Ostrosky-Frid, Alejandro Rodríguez-Gama, Norma Vázquez, Xochiquetzal Gonzalez-Rodriguez, Jesus Garcia-Valdes, Juliette Hadchouel, David Ellison, Gerardo Gamba

Am J Physiol Renal Physiol. 2018 Sep 1; 315(3): F734–F745. Published online 2018 May 30. doi: 10.1152/ajprenal.00145.2018

PMCID:: PMC6172580

Abstract Article

Select item 529301413.

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4

Maria Castañeda-Bueno, Juan Pablo Arroyo, Junhui Zhang, Jeremy Puthumana, Orlando Yarborough, III, Shigeru Shibata, Lorena Rojas-Vega, Gerardo Gamba, Jesse Rinehart, Richard P. Lifton

Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): E879–E886. Published online 2017 Jan 17. doi: 10.1073/pnas.1620315114

PMCID:: PMC5293014

Abstract Article PDF–1.4M

Select item 527573014.

Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study

Lingyun Wang, Ji‐Bin Peng

Protein Sci. 2017 Feb; 26(2): 163–173. Published online 2016 Oct 26. doi: 10.1002/pro.3063

PMCID:: PMC5275730

Abstract Article PDF–1.6M

Select item 490312515.

Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia

Nooshin Ghodsian, Patimah Ismail, Salma Ahmadloo, Farzad Heidari, Polin Haghvirdizadeh, Sima Ataollahi Eshkoor, Ali Etemad

J Diabetes Res. 2016; 2016: 8219543. Published online 2016 May 29. doi: 10.1155/2016/8219543

PMCID:: PMC4903125

Abstract Article PDF–728K

Select item 460468416.

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Frances-Rose Schumacher, Keith Siew, Jinwei Zhang, Clare Johnson, Nicola Wood, Sarah E Cleary, Raya S Al Maskari, James T Ferryman, Iris Hardege, Nichola L Figg, Radoslav Enchev, Axel Knebel, Kevin M O’Shaughnessy, Thimo Kurz

EMBO Mol Med. 2015 Oct; 7(10): 1285–1306. Published online 2015 Aug 18. doi: 10.15252/emmm.201505444

PMCID:: PMC4604684

Abstract Article PDF–2.5M

Select item 439429017.

Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK)

Dao-Hong Lin, Peng Yue, Orlando Yarborough, III, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang

Proc Natl Acad Sci U S A. 2015 Apr 7; 112(14): 4495–4500. Published online 2015 Mar 24. doi: 10.1073/pnas.1503437112

PMCID:: PMC4394290

Abstract Article PDF–905K

Select item 421746318.

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation

Shigeru Shibata, Juan Pablo Arroyo, María Castañeda-Bueno, Jeremy Puthumana, Junhui Zhang, Shunya Uchida, Kathryn L. Stone, TuKiet T. Lam, Richard P. Lifton

Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43): 15556–15561. Published online 2014 Oct 13. doi: 10.1073/pnas.1418342111