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Select item 108722611.

Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability

Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Veera V. Shivaji R. Edupuganti, Kuo-Sheng Hsu, Christopher Dower, Guojun Yu, Daeho So, Pradip Bajgain, Zhongyu Zhu, Dimiter S. Dimitrov, Nimit L. Patel, Christina M. Robinson, Simone Difilippantonio, Marzena Dyba, Amanda Corbel, Falguni Basuli, Rolf E. Swenson, Joseph D. Kalen, Sreedhar Reddy Suthe, Myer Hussain, James S. Italia, Colby A. Souders, Ling Gao, Martin J. Schnermann, Brad St. Croix

Cell Rep. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113503. Published online 2023 Nov 28. doi: 10.1016/j.celrep.2023.113503

PMCID:: PMC10872261

Abstract Article PDF–2.7M

Select item 96683062.

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

Rana Rais, Kathryn M. Lemberg, Lukáš Tenora, Matthew L. Arwood, Arindom Pal, Jesse Alt, Ying Wu, Jenny Lam, Joanna Marie H. Aguilar, Liang Zhao, Diane E. Peters, Carolyn Tallon, Rajeev Pandey, Ajit G. Thomas, Ranjeet P. Dash, Tanguy Seiwert, Pavel Majer, Robert D. Leone, Jonathan D. Powell, Barbara S. Slusher

Sci Adv. 2022 Nov; 8(46): eabq5925. Published online 2022 Nov 16. doi: 10.1126/sciadv.abq5925

PMCID:: PMC9668306

Abstract Article PDF–4.9M

Select item 95343593.

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Hao Li, Alessia Perino, Qingyao Huang, Giacomo V.G. Von Alvensleben, Amir Banaei-Esfahani, Laura A. Velazquez-Villegas, Karim Gariani, Melanie Korbelius, Maroun Bou Sleiman, Jéromine Imbach, Yu Sun, Xiaoxu Li, Alexis Bachmann, Ludger J.E. Goeminne, Hector Gallart-Ayala, Evan G. Williams, Julijana Ivanisevic, Johan Auwerx, Kristina Schoonjans

Cell Metab. 2022 Oct 4; 34(10): 1594–1610.e4. doi: 10.1016/j.cmet.2022.08.015

PMCID:: PMC9534359

Abstract Article

Select item 93492134.

An intranasal ASO therapeutic targeting SARS-CoV-2

Chi Zhu, Justin Y. Lee, Jia Z. Woo, Lei Xu, Xammy Nguyenla, Livia H. Yamashiro, Fei Ji, Scott B. Biering, Erik Van Dis, Federico Gonzalez, Douglas Fox, Eddie Wehri, Arjun Rustagi, Benjamin A. Pinsky, Julia Schaletzky, Catherine A. Blish, Charles Chiu, Eva Harris, Ruslan I. Sadreyev, Sarah Stanley, Sakari Kauppinen, Silvi Rouskin, Anders M. Näär

Nat Commun. 2022; 13: 4503. Published online 2022 Aug 3. doi: 10.1038/s41467-022-32216-0

PMCID:: PMC9349213

Abstract Article PDF–2.7M

Select item 82384505.

Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice

Erica Kundrick, Brenda Marrero-Rosado, Michael Stone, Caroline Schultz, Katie Walker, Robyn B. Lee-Stubbs, Marcio de Araujo Furtado, Lucille A. Lumley

Ann N Y Acad Sci. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Ann N Y Acad Sci. 2020 Nov; 1479(1): 94–107. Published online 2020 Feb 6. doi: 10.1111/nyas.14311

PMCID:: PMC8238450

Abstract Article PDF–2.3M

Select item 73400276.

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Andrea J. Pruijssers, Amelia S. George, Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinksi, Kenneth H. Dinnon, III, Boyd L. Yount, Maria L. Agostini, Laura J. Stevens, James D. Chappell, Xiaotao Lu, Tia M. Hughes, Kendra Gully, David R. Martinez, Ariane J. Brown, Rachel L. Graham, Jason K. Perry, Venice Du Pont, Jared Pitts, Bin Ma, Darius Babusis, Eisuke Murakami, Joy Y. Feng, John P. Bilello, Danielle P. Porter, Tomas Cihlar, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan

Cell Rep. 2020 Jul 21; 32(3): 107940. Published online 2020 Jul 7. doi: 10.1016/j.celrep.2020.107940

PMCID:: PMC7340027

Abstract Article PDF–2.4M

Select item 69543027.

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric

Nat Commun. 2020; 11: 222. Published online 2020 Jan 10. doi: 10.1038/s41467-019-13940-6

PMCID:: PMC6954302

Abstract Article PDF–2.3M

Select item 55678178.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan, Amy C. Sims, Rachel L. Graham, Vineet D. Menachery, Lisa E. Gralinski, James B. Case, Sarah R. Leist, Krzysztof Pyrc, Joy Y. Feng, Iva Trantcheva, Roy Bannister, Yeojin Park, Darius Babusis, Michael O. Clarke, Richard L. Mackman, Jamie E. Spahn, Christopher A. Palmiotti, Dustin Siegel, Adrian S. Ray, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric

Sci Transl Med. Author manuscript; available in PMC 2017 Aug 23.

Published in final edited form as: Sci Transl Med. 2017 Jun 28; 9(396): eaal3653. doi: 10.1126/scitranslmed.aal3653

PMCID:: PMC5567817

Abstract Article PDF–1.8M

Select item 43824279.

Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: Implications for their clinical pharmacology

Chi C. Wong, Ka-Wing Cheng, Ioannis Papayannis, George Mattheolabakis, Liqun Huang, Gang Xie, Nengtai Ouyang, Basil Rigas

Pharm Res. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Pharm Res. 2015 May; 32(5): 1663–1675. Published online 2014 Nov 13. doi: 10.1007/s11095-014-1565-2

PMCID:: PMC4382427

Abstract Article PDF–2.2M

Select item 418684010.

Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels

Jiesi Xu, Liya Yin, Yang Xu, Yuanyuan Li, Munaf Zalzala, Gang Cheng, Yanqiao Zhang

PLoS One. 2014; 9(10): e109663. Published online 2014 Oct 6. doi: 10.1371/journal.pone.0109663

PMCID:: PMC4186840

Abstract Article PDF–669K

Select item 369668911.

Control of RhoA Methylation by Carboxylesterase I

Ian Cushman, Stephanie M. Cushman, Philip M. Potter, Patrick J. Casey

J Biol Chem. 2013 Jun 28; 288(26): 19177–19183. Published online 2013 May 8. doi: 10.1074/jbc.M113.467407

PMCID:: PMC3696689

Abstract Article PDF–902K

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 347860613.

Impact of lactobacilli on orally acquired listeriosis

Cristel Archambaud, Marie-Anne Nahori, Guillaume Soubigou, Christophe Bécavin, Laure Laval, Pierre Lechat, Tamara Smokvina, Philippe Langella, Marc Lecuit, Pascale Cossart

Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41): 16684–16689. Published online 2012 Sep 24. doi: 10.1073/pnas.1212809109

PMCID:: PMC3478606

Abstract Article PDF–772K

Select item 322192314.

Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies

Ellen G. Duysen, Frank Koentgen, Gareth R. Williams, Christopher M. Timperley, Lawrence M. Schopfer, Douglas M. Cerasoli, Oksana Lockridge

Chem Res Toxicol. Author manuscript; available in PMC 2012 Nov 21.

Published in final edited form as: Chem Res Toxicol. 2011 Nov 21; 24(11): 1891–1898. Published online 2011 Sep 7. doi: 10.1021/tx200237a

PMCID:: PMC3221923

Abstract Article PDF–1.0M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 314624716.

Esterase 1 is a Novel Transcriptional Repressor of Growth Hormone Receptor Gene Expression: A Unique Noncatalytic Role for a Carboxyesterase Protein

Jinhong Sun, P. Anil Kumar, Jamuna Thimmarayappa, Natinder Saini, Pooja Goel, Travis Maures, Chunxia Lu, Ram K. Menon

Mol Endocrinol. 2011 Aug; 25(8): 1351–1363. Published online 2011 Jun 9. doi: 10.1210/me.2011-0097

PMCID:: PMC3146247

Abstract Article

Select item 312720617.

Roger S. Holmes, Matthew W. Wright, Stanley J. F. Laulederkind, Laura A. Cox, Masakiyo Hosokawa, Teruko Imai, Shun Ishibashi, Richard Lehner, Masao Miyazaki, Everett J. Perkins, Phillip M. Potter, Matthew R. Redinbo, Jacques Robert, Tetsuo Satoh, Tetsuro Yamashita, Bingfan Yan, Tsuyoshi Yokoi, Rudolf Zechner, Lois J. Maltais

Mamm Genome. Author manuscript; available in PMC 2011 Oct 8.

Published in final edited form as: Mamm Genome. 2010 Oct; 21(9-10): 427–441. Published online 2010 Oct 8. doi: 10.1007/s00335-010-9284-4

PMCID:: PMC3127206

Abstract Article PDF–1.0M

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 218664619.

Allelism and linkage studies of murine leukemia virus activation genes in low leukemic strains of mice

J Exp Med. 1982 Apr 1; 155(4): 1233–1238. doi: 10.1084/jem.155.4.1233

PMCID:: PMC2186646

Summary PDF–367K

Select item 218658620.

Genetic mapping of ecotropic murine leukemia virus-inducing loci in six inbred strains

J Exp Med. 1982 Feb 1; 155(2): 524–534. doi: 10.1084/jem.155.2.524

PMCID:: PMC2186586

Summary PDF–783K

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