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Items: 1 to 20 of 53

1.
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis
Song-tao Xue, Bin Zheng, Shi-qiang Cao, Jian-cheng Ding, Guo-sheng Hu, Wen Liu, Chun Chen
Mol Cancer. 2022; 21: 69. Published online 2022 Mar 7. doi: 10.1186/s12943-022-01539-3
PMCID:
PMC8900330
AbstractArticlePDF–5.4M
2.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
3.
The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML
Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Blood. 2020 Jul 30; 136(5): 596–609. Prepublished online 2020 Apr 8. doi: 10.1182/blood.2019003636
PMCID:
PMC7485576
AbstractArticle
4.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
5.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
6.
Mitochondrial PAK6 inhibits prostate cancer cell apoptosis via the PAK6-SIRT4-ANT2 complex
Tingting Li, Yang Li, Tong Liu, Bingtao Hu, Jiabin Li, Chen Liu, Tao Liu, Feng Li
Theranostics. 2020; 10(6): 2571–2586. Published online 2020 Feb 3. doi: 10.7150/thno.42874
PMCID:
PMC7052886
AbstractArticlePDF–2.4M
7.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9
PMCID:
PMC6981206
AbstractArticlePDF–3.7M
8.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
9.
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari
Mol Cell. Author manuscript; available in PMC 2020 Feb 21.
Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001
PMCID:
PMC6386588
AbstractArticlePDF–1.7M
10.
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni
Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444
PMCID:
PMC5992104
AbstractArticlePDF–1.2M
11.
Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7
Kailiang Zhao, Yang Yang, Guang Zhang, Chenfeng Wang, Decai Wang, Mian Wu, Yide Mei
EMBO Rep. 2018 Feb; 19(2): 305–319. Published online 2018 Jan 2. doi: 10.15252/embr.201744465
PMCID:
PMC5797962
AbstractArticlePDF–2.1M
12.
Prognostic and Predictive Value of p21-activated Kinase 6 Associated Support Vector Machine Classifier in Gastric Cancer Treated by 5-fluorouracil/Oxaliplatin Chemotherapy
Yuming Jiang, Wei Liu, Tuanjie Li, Yanfeng Hu, Sile Chen, Sujuan Xi, Yajia Wen, Lei Huang, Liying Zhao, Cuicui Xiao, Xiaohui Huang, Zhen Han, Hao Liu, Xiaolong Qi, Yang Yang, Jiang Yu, Shirong Cai, Guoxin Li
EBioMedicine. 2017 Aug; 22: 78–88. Published online 2017 Jul 1. doi: 10.1016/j.ebiom.2017.06.028
PMCID:
PMC5552213
AbstractArticlePDF–2.5M
13.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
14.
RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6
Charlotte H. Durkin, Flavia Leite, João V. Cordeiro, Yutaka Handa, Yoshiki Arakawa, Ferran Valderrama, Michael Way
Dev Cell. 2017 May 8; 41(3): 315–329.e7. doi: 10.1016/j.devcel.2017.04.010
PMCID:
PMC5425256
AbstractArticlePDF–5.2M
15.
Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells
Remya Raja, Nandini A. Sahasrabuddhe, Aneesha Radhakrishnan, Nazia Syed, Hitendra S. Solanki, Vinuth N. Puttamallesh, Sai A. Balaji, Vishalakshi Nanjappa, Keshava K. Datta, Niraj Babu, Santosh Renuse, Arun H. Patil, Evgeny Izumchenko, T.S. Keshava Prasad, Xiaofei Chang, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee
Oncotarget. 2016 Sep 20; 7(38): 61229–61245. Published online 2016 Aug 16. doi: 10.18632/oncotarget.11310
PMCID:
PMC5308647
AbstractArticlePDF–6.1M
16.
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman
Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387
PMCID:
PMC5260939
AbstractArticlePDF–1.1M
17.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
Zhenhuan Guo, Lisa J Neilson, Hang Zhong, Paul S Murray, Megha Vaman Rao, Sara Zanivan, Ronen Zaidel-Bar
Sci Signal. Author manuscript; available in PMC 2016 Aug 3.
Published in final edited form as: Sci Signal. 2014 Dec 2; 7(354): rs7. Published online 2014 Dec 2. doi: 10.1126/scisignal.2005473
PMCID:
PMC4972397
AbstractArticlePDF–3.1M
18.
PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape
Elizabeth M. Morse, Xiaowen Sun, Jordan R. Olberding, Byung Hak Ha, Titus J. Boggon, David A. Calderwood
J Cell Sci. 2016 Jan 15; 129(2): 380–393. doi: 10.1242/jcs.177493
PMCID:
PMC4732285
AbstractArticle
19.
Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain
Laura Civiero, Maria Daniela Cirnaru, Alexandra Beilina, Umberto Rodella, Isabella Russo, Elisa Belluzzi, Evy Lobbestael, Lauran Reyniers, Geshanthi Hondhamuni, Patrick A. Lewis, Chris Van den Haute, Veerle Baekelandt, Rina Bandopadhyay, Luigi Bubacco, Giovanni Piccoli, Mark R. Cookson, Jean‐Marc Taymans, Elisa Greggio
J Neurochem. 2015 Dec; 135(6): 1242–1256. Published online 2015 Oct 19. doi: 10.1111/jnc.13369
PMCID:
PMC4715492
AbstractArticlePDF–1.4M
20.
Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma
Weisi Liu, Yidong Liu, Haiou Liu, Weijuan Zhang, Qiang Fu, Jiejie Xu, Jianxin Gu
J Biol Chem. 2015 Nov 20; 290(47): 28489–28501. Published online 2015 Oct 6. doi: 10.1074/jbc.M115.658237
PMCID:
PMC4653705
AbstractArticlePDF–4.4M

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