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Select item 109319811.

5′-Isoforms of miR-1246 Have Distinct Targets and Stronger Functional Impact Compared with Canonical miR-1246 in Colorectal Cancer Cells In Vitro

Rokas Lukosevicius, Gediminas Alzbutas, Greta Varkalaite, Violeta Salteniene, Deimante Tilinde, Simonas Juzenas, Ugne Kulokiene, Dainius Janciauskas, Lina Poskiene, Kestutis Adamonis, Gediminas Kiudelis, Juozas Kupcinskas, Jurgita Skieceviciene

Int J Mol Sci. 2024 Mar; 25(5): 2808. Published online 2024 Feb 28. doi: 10.3390/ijms25052808

PMCID:: PMC10931981

Article PDF–2.1M

Select item 108236342.

Aseptic loosening around total joint replacement in humans is regulated by miR-1246 and miR-6089 via the Wnt signalling pathway

Yi Deng, Kate Phillips, Zhi-Ping Feng, Paul N. Smith, Rachel W. Li

J Orthop Surg Res. 2024; 19: 94. Published online 2024 Jan 29. doi: 10.1186/s13018-024-04578-2

PMCID:: PMC10823634

Article PDF–1.5M

Select item 106920823.

MiR-1246b, a novel miRNA molecule of extracellular vesicles in bronchoalveolar lavage fluid, promotes nodule growth through FGF14 in patients with lung cancer

Jing Huang, Ming Ding, Yuan Lu, Lu Xu, Yu Zhang, Shuhua Han, Xiaoli Zhu, Yiping Li, Pingsheng Chen

Cell Death Dis. 2023 Dec; 14(12): 789. Published online 2023 Dec 1. doi: 10.1038/s41419-023-06218-9

PMCID:: PMC10692082

Article PDF–8.6M

Select item 106304044.

Identification of serum miR-1246 and miR-150-5p as novel diagnostic biomarkers for high-grade serous ovarian cancer

Magdalena Niemira, Anna Erol, Agnieszka Bielska, Anna Zeller, Anna Skwarska, Karolina Chwialkowska, Mariusz Kuzmicki, Jacek Szamatowicz, Joanna Reszec, Pawel Knapp, Marcin Moniuszko, Adam Kretowski

Sci Rep. 2023; 13: 19287. Published online 2023 Nov 7. doi: 10.1038/s41598-023-45317-7

PMCID:: PMC10630404

Article PDF–2.8M

Select item 105614415.

CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells

Bei Xie, Lei Zhao, Zhewen Zhang, Cunmin Zhou, Ye Tian, Yingying Kang, Jing Chen, Hulai Wei, Linjing Li

BMC Cancer. 2023; 23: 955. Published online 2023 Oct 9. doi: 10.1186/s12885-023-11458-1

PMCID:: PMC10561441

Article PDF–1.6M

Select item 101398026.

The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis

Khanh Quang Huynh, Anh Tuan Le, Thang Thanh Phan, Toan Trong Ho, Suong Phuoc Pho, Hang Thuy Nguyen, Binh Thanh Le, Thuc Tri Nguyen, Son Truong Nguyen

Oxid Med Cell Longev. 2023; 2023: 8379231. Published online 2023 Apr 20. doi: 10.1155/2023/8379231

PMCID:: PMC10139802

Article PDF–774K

Select item 98370097.

In silico and in vitro analysis of the impact of single substitutions within EXO-motifs on Hsa-MiR-1246 intercellular transfer in breast cancer cell

Agnieszka Rybarczyk, Tomasz Lehmann, Ewa Iwańczyk-Skalska, Wojciech Juzwa, Andrzej Pławski, Kamil Kopciuch, Jacek Blazewicz, Paweł P. Jagodziński

J Appl Genet. 2023; 64(1): 105–124. Published online 2022 Nov 17. doi: 10.1007/s13353-022-00730-y

PMCID:: PMC9837009

Article PDF–5.0M

Select item 95272098.

Deficiency of p53 Causes the Inadequate Expression of miR-1246 in B Cells of Systemic Lupus Erythematosus

Qing Zhang, Yu Liu, Jieyue Liao, Ruifang Wu, Yi Zhan, Peng Zhang, Shuangyan Luo

J Immunol. 2022 Oct 15; 209(8): 1492–1498. Published online 2022 Oct 15. doi: 10.4049/jimmunol.2200307

PMCID:: PMC9527209

Article PDF–996K

Select item 88955089.

Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Panpan Liu, Qun Zhang, Jun Mi, Shuangshuang Wang, Qiuping Xu, Dexuan Zhuang, Wenqian Chen, Chang Liu, Liwei Zhang, Jing Guo, Xunwei Wu

Stem Cell Res Ther. 2022; 13: 89. Published online 2022 Mar 3. doi: 10.1186/s13287-022-02764-9

PMCID:: PMC8895508

Article PDF–5.4M

Select item 887601010.

miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting AXIN2 and CFTR

Rokas Lukosevicius, Simonas Juzenas, Violeta Salteniene, Ugne Kulokiene, Justina Arstikyte, Georg Hemmrich-Stanisak, Andre Franke, Alexander Link, Paulius Ruzgys, Saulius Satkauskas, Henrikas Pauzas, Tadas Latkauskas, Gediminas Kiudelis, Francesc Balaguer, Juozas Kupcinskas, Jurgita Skieceviciene

Int J Mol Sci. 2022 Feb; 23(4): 2107. Published online 2022 Feb 14. doi: 10.3390/ijms23042107

PMCID:: PMC8876010

Article PDF–1.6M

Select item 885708411.

MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth

Jingyan Li, Zhanlei Zhang, Jieting Hu, Xiaoting Wan, Wei Huang, Hong Zhang, Ningyi Jiang

Mol Cell Biochem. 2022; 477(3): 649–661. Published online 2021 Dec 6. doi: 10.1007/s11010-021-04290-3

PMCID:: PMC8857084

Article PDF–11M

Select item 863617612.

Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells

Wei Qiu, Xiaofan Guo, Boyan Li, Jian Wang, Yanhua Qi, Zihang Chen, Rongrong Zhao, Lin Deng, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Qindong Guo, Shouji Zhang, Ziwen Pan, Shulin Zhao, Hao Xue, Gang Li

Mol Ther. 2021 Dec 1; 29(12): 3449–3464. Published online 2021 Jul 2. doi: 10.1016/j.ymthe.2021.06.023

PMCID:: PMC8636176

Article PDF–5.1M

Select item 834223213.

lncRNA Mirt2 upregulates miR‐1246 through methylation to suppress LPS‐induced lung cell apoptosis

Xuwen Xu, Yuyuan Xu, Xin Tao, Guangyu Liang

Immun Inflamm Dis. 2021 Sep; 9(3): 695–701. Published online 2021 May 4. doi: 10.1002/iid3.422

PMCID:: PMC8342232

Article PDF–1.3M

Select item 825758214.

miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells

Chisaho Torii, Nako Maishi, Taisuke Kawamoto, Masahiro Morimoto, Kosuke Akiyama, Yusuke Yoshioka, Takashi Minami, Takuya Tsumita, Mohammad Towfik Alam, Takahiro Ochiya, Yasuhiro Hida, Kyoko Hida

Sci Rep. 2021; 11: 13502. Published online 2021 Jul 5. doi: 10.1038/s41598-021-92879-5

PMCID:: PMC8257582

Article PDF–1.8M

Select item 820288415.

microRNA-1246-containing extracellular vesicles from acute myeloid leukemia cells promote the survival of leukemia stem cells via the LRIG1-meditated STAT3 pathway

Lijuan Chen, Zhi Guo, Yongming Zhou, Jian Ni, Jianhua Zhu, Xu Fan, Xuexing Chen, Yiling Liu, Ziping Li, Hao Zhou

Aging (Albany NY) 2021 May 31; 13(10): 13644–13662. Published online 2021 Apr 23. doi: 10.18632/aging.202893

PMCID:: PMC8202884

Article PDF–2.4M

Select item 794627916.

Cell-free microRNA-1246 in different body fluids as a diagnostic biomarker for esophageal squamous cell carcinoma

Isamu Hoshino, Fumitaka Ishige, Yosuke Iwatate, Hisashi Gunji, Naoki Kuwayama, Yoshihiro Nabeya, Hajime Yokota, Nobuyoshi Takeshita, Keiko Iida, Hiroki Nagase, Hisahiro Matsubara

PLoS One. 2021; 16(3): e0248016. Published online 2021 Mar 10. doi: 10.1371/journal.pone.0248016