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Items: 1 to 20 of 44

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut resident plasma cells
Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Benedikt Mortzfeld, Shakti K. Bhattarai, Nicole K. H. Yiew, Ying Xu, Robert Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Vanni Bucci, Andrea Reboldi
Nat Immunol. Author manuscript; available in PMC 2023 Jun 6.
Published in final edited form as: Nat Immunol. 2023 Mar; 24(3): 531–544. Published online 2023 Jan 19. doi: 10.1038/s41590-022-01413-w
PMCID:
PMC10243503
AbstractArticlePDF–7.1M
3.
CYP27A1 deficiency promoted osteoclast differentiation
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
PeerJ. 2023; 11: e15041. Published online 2023 Mar 3. doi: 10.7717/peerj.15041
PMCID:
PMC9987298
AbstractArticlePDF–11M
4.
Bile acid-sensitive tuft cells regulate biliary neutrophil influx
Claire E. O’Leary, Julia Sbierski-Kind, Maya E. Kotas, Johanna C. Wagner, Hong-Erh Liang, Andrew W. Schroeder, Jeshua C. de Tenorio, Jakob von Moltke, Roberto R. Ricardo-Gonzalez, Walter L. Eckalbar, Ari Molofsky, Christoph Schneider, Richard M. Locksley
Sci Immunol. Author manuscript; available in PMC 2022 Jun 4.
Published in final edited form as: Sci Immunol. 2022 Mar 4; 7(69): eabj1080. Published online 2022 Mar 4. doi: 10.1126/sciimmunol.abj1080
PMCID:
PMC9166270
AbstractArticlePDF–2.6M
5.
2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1-/-Cyp46a1-/- mice with deficiency in the oxysterol production
Nicole El-Darzi, Natalia Mast, Alexey M. Petrov, Irina A. Pikuleva
Br J Pharmacol. Author manuscript; available in PMC 2022 Jan 19.
Published in final edited form as: Br J Pharmacol. 2021 Aug; 178(16): 3220–3234. Published online 2020 Aug 13. doi: 10.1111/bph.15209
PMCID:
PMC8767317
AbstractArticlePDF–1.7M
6.
Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice
Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M. Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D. Moore, Li Yang, Wendong Huang
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2019388118. Published online 2021 Feb 1. doi: 10.1073/pnas.2019388118
PMCID:
PMC8017941
AbstractArticlePDF–3.2M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.
Liqian Ma, Lawrence Wang, Adam T. Nelson, Chaeyeon Han, Sisi He, Madeline A. Henn, Karan Menon, Joy J. Chen, Amy E. Baek, Anna Vardanyan, Sayyed Hamed Shahoei, Sunghee Park, David J. Shapiro, Som G. Nanjappa, Erik R. Nelson
Cancer Lett. Author manuscript; available in PMC 2021 Nov 28.
Published in final edited form as: Cancer Lett. 2020 Nov 28; 493: 266–283. Published online 2020 Aug 28. doi: 10.1016/j.canlet.2020.08.020
PMCID:
PMC7572761
AbstractArticlePDF–2.3M
9.
Host CYP27A1 expression is essential for ovarian cancer progression.
Sisi He, Liqian Ma, Amy E. Baek, Anna Vardanyan, Varsha Vembar, Joy J. Chen, Adam T. Nelson, Joanna E. Burdette, Erik R. Nelson
Endocr Relat Cancer. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Endocr Relat Cancer. 2019 Jul; 26(7): 659–675. doi: 10.1530/ERC-18-0572
PMCID:
PMC6824983
AbstractArticlePDF–2.2M
10.
Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal
Aicha Saadane, Natalia Mast, George Trichonas, Dibyendu Chakraborty, Sandra Hammer, Julia V. Busik, Maria B. Grant, Irina A. Pikuleva
Am J Pathol. 2019 Feb; 189(2): 405–425. doi: 10.1016/j.ajpath.2018.10.013
PMCID:
PMC6360352
AbstractArticle
11.
Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma
William J. Griffiths, Peter J. Crick, Anna Meljon, Spyridon Theofilopoulos, Jonas Abdel-Khalik, Eylan Yutuc, Josie E. Parker, Diane E. Kelly, Steven L. Kelly, Ernest Arenas, Yuqin Wang
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb; 1864(2): 191–211. doi: 10.1016/j.bbalip.2018.11.006
PMCID:
PMC6327153
AbstractArticle
12.
Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice
Line Zurkinden, Dmitri Sviridov, Bruno Vogt, Geneviève Escher
Biosci Rep. 2018 Feb 28; 38(1): BSR20171162. Prepublished online 2017 Nov 30. Published online 2018 Jan 25. doi: 10.1042/BSR20171162
PMCID:
PMC5784176
AbstractArticlePDF–2.8M
13.
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell, Erik R. Nelson
Nat Commun. 2017; 8: 864. Published online 2017 Oct 11. doi: 10.1038/s41467-017-00910-z
PMCID:
PMC5636879
AbstractArticlePDF–672K
14.
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum
Natalia Mast, Kyle W. Anderson, Joseph B. Lin, Yong Li, Illarion V. Turko, Curtis Tatsuoka, Ingemar Bjorkhem, Irina A. Pikuleva
J Biol Chem. 2017 Mar 24; 292(12): 4913–4924. Published online 2017 Feb 11. doi: 10.1074/jbc.M116.774760
PMCID:
PMC5377805
AbstractArticlePDF–2.5M
15.
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
Muhammad-Al-Mustafa Ismail, Laura Mateos, Silvia Maioli, Paula Merino-Serrais, Zeina Ali, Maria Lodeiro, Eric Westman, Eran Leitersdorf, Balázs Gulyás, Lars Olof-Wahlund, Bengt Winblad, Irina Savitcheva, Ingemar Björkhem, Angel Cedazo-Mínguez
J Exp Med. 2017 Mar 6; 214(3): 699–717. doi: 10.1084/jem.20160534
PMCID:
PMC5339669
AbstractArticlePDF–2.7M
16.
Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells
Aicha Saadane, Natalia Mast, Tung Dao, Baseer Ahmad, Irina A. Pikuleva
J Biol Chem. 2016 Sep 23; 291(39): 20427–20439. Published online 2016 Aug 11. doi: 10.1074/jbc.M116.744656
PMCID:
PMC5034040
AbstractArticlePDF–3.7M
17.
Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders
Jessica M. Ferrell, Shannon Boehme, Feng Li, John Y. L. Chiang
J Lipid Res. 2016 Jul; 57(7): 1144–1154. doi: 10.1194/jlr.M064709
PMCID:
PMC4918844
AbstractArticlePDF–1.3M
18.
Mutations in the Bile Acid Biosynthetic Enzyme Sterol 27-Hydroxylase Underlie Cerebrotendinous Xanthomatosis
James J. Cali, Chih-Lin Hsieh, Uta Francke, David W. Russell
J Biol Chem. Author manuscript; available in PMC 2015 May 30.
Published in final edited form as: J Biol Chem. 1991 Apr 25; 266(12): 7779–7783.
PMCID:
PMC4449724
AbstractArticlePDF–579K
19.
Cholestenoic acids regulate motor neuron survival via liver X receptors
Spyridon Theofilopoulos, William J. Griffiths, Peter J. Crick, Shanzheng Yang, Anna Meljon, Michael Ogundare, Satish Srinivas Kitambi, Andrew Lockhart, Karin Tuschl, Peter T. Clayton, Andrew A. Morris, Adelaida Martinez, M. Ashwin Reddy, Andrea Martinuzzi, Maria T. Bassi, Akira Honda, Tatsuki Mizuochi, Akihiko Kimura, Hiroshi Nittono, Giuseppe De Michele, Rosa Carbone, Chiara Criscuolo, Joyce L. Yau, Jonathan R. Seckl, Rebecca Schüle, Ludger Schöls, Andreas W. Sailer, Jens Kuhle, Matthew J. Fraidakis, Jan-Åke Gustafsson, Knut R. Steffensen, Ingemar Björkhem, Patrik Ernfors, Jan Sjövall, Ernest Arenas, Yuqin Wang
J Clin Invest. 2014 Nov 3; 124(11): 4829–4842. Published online 2014 Oct 1. doi: 10.1172/JCI68506
PMCID:
PMC4347238
AbstractArticlePDF–2.1M
20.
Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments
Wenchao Zheng, Natalia Mast, Aicha Saadane, Irina A. Pikuleva
J Lipid Res. 2015 Jan; 56(1): 81–97. doi: 10.1194/jlr.M053439
PMCID:
PMC4274074
AbstractArticlePDF–3.1M

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