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Select item 109546161.

Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape

Anastasiia Lozovska, Artemis G. Korovesi, André Dias, Alexandre Lopes, Donald A. Fowler, Gabriel G. Martins, Ana Nóvoa, Moisés Mallo

Nat Commun. 2024; 15: 2509. Published online 2024 Mar 20. doi: 10.1038/s41467-024-46870-z

PMCID:: PMC10954616

Abstract Article PDF–9.6M

Select item 109017392.

A single-cell time-lapse of mouse prenatal development from gastrula to birth

Chengxiang Qiu, Beth K. Martin, Ian C. Welsh, Riza M. Daza, Truc-Mai Le, Xingfan Huang, Eva K. Nichols, Megan L. Taylor, Olivia Fulton, Diana R. O’Day, Anne Roshella Gomes, Saskia Ilcisin, Sanjay Srivatsan, Xinxian Deng, Christine M. Disteche, William Stafford Noble, Nobuhiko Hamazaki, Cecilia B. Moens, David Kimelman, Junyue Cao, Alexander F. Schier, Malte Spielmann, Stephen A. Murray, Cole Trapnell, Jay Shendure

Nature. 2024; 626(8001): 1084–1093. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07069-w

PMCID:: PMC10901739

Abstract Article PDF–63M

Select item 107743623.

miR-195b is required for proper cellular homeostasis in the elderly

Maria del Mar Muñoz-Gallardo, Carlos Garcia-Padilla, Cristina Vicente-Garcia, Jaime Carvajal, Amelia Arenega, Diego Franco

Sci Rep. 2024; 14: 810. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51256-8

PMCID:: PMC10774362

Abstract Article PDF–3.7M

Select item 106296814.

The Tbx20-TLE interaction is essential for the maintenance of the second heart field

Whitney Edwards, Olivia K. Bussey, Frank L. Conlon

Development. 2023 Nov 1; 150(21): dev201677. Published online 2023 Oct 30. doi: 10.1242/dev.201677

PMCID:: PMC10629681

Abstract Article

Select item 105229995.

Acquisition of neural fate by combination of BMP blockade and chromatin modification

Agnes Lee Chen Ong, Toshiya Kokaji, Arisa Kishi, Yoshihiro Takihara, Takuma Shinozuka, Ren Shimamoto, Ayako Isotani, Manabu Shirai, Noriaki Sasai

iScience. 2023 Oct 20; 26(10): 107887. Published online 2023 Sep 9. doi: 10.1016/j.isci.2023.107887

Correction in:: iScience. 2023 Nov 17; 26(11): 108257.

PMCID:: PMC10522999

Abstract Article PDF–6.7M

Select item 104787546.

CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression

Athanasia Stathopoulou, Ping Wang, Charlotte Thellier, Robert G Kelly, Deyou Zheng, Peter J Scambler

Cardiovasc Res. 2023 Aug; 119(11): 2089–2105. Published online 2023 Apr 13. doi: 10.1093/cvr/cvad059

Correction in:: Cardiovasc Res. 2024 Jan; 120(1): 120.

PMCID:: PMC10478754

Abstract Article PDF–21M

Select item 101191217.

Topologically associating domain boundaries are required for normal genome function

Sudha Rajderkar, Iros Barozzi, Yiwen Zhu, Rong Hu, Yanxiao Zhang, Bin Li, Ana Alcaina Caro, Yoko Fukuda-Yuzawa, Guy Kelman, Adyam Akeza, Matthew J. Blow, Quan Pham, Anne N. Harrington, Janeth Godoy, Eman M. Meky, Kianna von Maydell, Riana D. Hunter, Jennifer A. Akiyama, Catherine S. Novak, Ingrid Plajzer-Frick, Veena Afzal, Stella Tran, Javier Lopez-Rios, Michael E. Talkowski, K. C. Kent Lloyd, Bing Ren, Diane E. Dickel, Axel Visel, Len A. Pennacchio

Commun Biol. 2023; 6: 435. Published online 2023 Apr 20. doi: 10.1038/s42003-023-04819-w

PMCID:: PMC10119121

Abstract Article PDF–3.2M

Select item 99428808.

Cardiac progenitors instruct second heart field fate through Wnts

Matthew Miyamoto, Suraj Kannan, Matthew J. Anderson, Xihe Liu, David Suh, Myo Htet, Biyi Li, Tejasvi Kakani, Sean Murphy, Emmanouil Tampakakis, Mark Lewandoski, Peter Andersen, Hideki Uosaki, Chulan Kwon

Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2217687120. Published online 2023 Jan 17. doi: 10.1073/pnas.2217687120

PMCID:: PMC9942880

Abstract Article PDF–2.0M

Select item 99284249.

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arie O Verkerk, Bastiaan J Boukens, Vincent M Christoffels

eLife. 2023; 12: e80317. Published online 2023 Jan 30. doi: 10.7554/eLife.80317

PMCID:: PMC9928424

Abstract Article PDF–6.6M

Select item 968001710.

Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment

Rasmani Hazra, Lily Brine, Libia Garcia, Brian Benz, Napon Chirathivat, Michael M. Shen, John Erby Wilkinson, Scott K. Lyons, David L. Spector

Dev Cell. Author manuscript; available in PMC 2023 Nov 7.

Published in final edited form as: Dev Cell. 2022 Nov 7; 57(21): 2450–2468.e7. doi: 10.1016/j.devcel.2022.10.002

PMCID:: PMC9680017

Abstract Article PDF–2.9M

Select item 956099911.

The Transcription Factor Tbx5 Regulates Direction-Selective Retinal Ganglion Cell Development and Image Stabilization

Timour Al-Khindi, Michael Sherman, Takashi Kodama, Preethi Gopal, Zhiwei Pan, James Kiraly, Hao Zhang, Loyal A. Goff, Sascha du Lac, Alex L. Kolodkin

Curr Biol. Author manuscript; available in PMC 2023 Oct 10.

Published in final edited form as: Curr Biol. 2022 Oct 10; 32(19): 4286–4298.e5. Published online 2022 Aug 22. doi: 10.1016/j.cub.2022.07.064

PMCID:: PMC9560999

Abstract Article PDF–1.2M

Select item 953153512.

NOTCH maintains developmental cardiac gene network through WNT5A

Yidong Wang, Pengfei Lu, Bingruo Wu, Bernice E. Morrow, Bin Zhou

J Mol Cell Cardiol. Author manuscript; available in PMC 2022 Oct 4.

Published in final edited form as: J Mol Cell Cardiol. 2018 Dec; 125: 98–105. Published online 2018 Oct 19. doi: 10.1016/j.yjmcc.2018.10.014

PMCID:: PMC9531535

Abstract Article PDF–1.3M

Select item 945251913.

devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data

Francisco X. Galdos, Sidra Xu, William R. Goodyer, Lauren Duan, Yuhsin V. Huang, Soah Lee, Han Zhu, Carissa Lee, Nicholas Wei, Daniel Lee, Sean M. Wu

Nat Commun. 2022; 13: 5271. Published online 2022 Sep 7. doi: 10.1038/s41467-022-33045-x

PMCID:: PMC9452519

Abstract Article PDF–10M

Select item 917081814.

Maternal nicotine exposure induces congenital heart defects in the offspring of mice

Elizabeth R. Greco, Anish Engineer, Tana Saiyin, Xiangru Lu, MengQi Zhang, Douglas L. Jones, Qingping Feng

J Cell Mol Med. 2022 Jun; 26(11): 3223–3234. Published online 2022 May 6. doi: 10.1111/jcmm.17328

PMCID:: PMC9170818

Abstract Article PDF–4.0M

Select item 906740615.

CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart

Zachary L. Robbe, Wei Shi, Lauren K. Wasson, Angel P. Scialdone, Caralynn M. Wilczewski, Xinlei Sheng, Austin J. Hepperla, Brynn N. Akerberg, William T. Pu, Ileana M. Cristea, Ian J. Davis, Frank L. Conlon

Genes Dev. 2022 Apr 1; 36(7-8): 468–482. doi: 10.1101/gad.349154.121

PMCID:: PMC9067406

Abstract Article PDF–8.4M

Select item 886087916.

PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle

Tongbin Wu, Zhengyu Liang, Zengming Zhang, Canzhao Liu, Lunfeng Zhang, Yusu Gu, Kirk L. Peterson, Sylvia M. Evans, Xiang-Dong Fu, Ju Chen

Circulation. Author manuscript; available in PMC 2023 Feb 22.

Published in final edited form as: Circulation. 2022 Feb 22; 145(8): 586–602. Published online 2021 Dec 17. doi: 10.1161/CIRCULATIONAHA.121.056666

PMCID:: PMC8860879

Abstract Article PDF–2.5M

Select item 886022317.

Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction

Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Arjan C. Houweling, Koen T. Scholman, Vincent Wakker, Cornelis P. Allaart, Jae-Sun Uhm, Inge B. Mathijssen, Ton Baartscheer, Alex V. Postma, Phil Barnett, Arie O. Verkerk, Bastiaan J. Boukens, Vincent M. Christoffels

Circulation. 2022 Feb 22; 145(8): 606–619. Published online 2022 Feb 3. doi: 10.1161/CIRCULATIONAHA.121.054347

PMCID:: PMC8860223

Abstract Article PDF–2.2M

Select item 855598618.

Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

Scott A Rankin, Jeffrey D Steimle, Xinan H Yang, Ariel B Rydeen, Kunal Agarwal, Praneet Chaturvedi, Kohta Ikegami, Michael J Herriges, Ivan P Moskowitz, Aaron M Zorn

eLife. 2021; 10: e69288. Published online 2021 Oct 13. doi: 10.7554/eLife.69288

PMCID:: PMC8555986

Abstract Article PDF–11M

Select item 852881919.

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida

Commun Biol. 2021; 4: 1204. Published online 2021 Oct 20. doi: 10.1038/s42003-021-02734-6

PMCID:: PMC8528819

Abstract Article PDF–3.6M

Select item 849777820.

Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects

Veronique Duboc, Fatima A. Sulaiman, Eleanor Feneck, Anna Kucharska, Donald Bell, Muriel Holder-Espinasse, Malcolm P. O. Logan

Development. 2021 Oct 1; 148(19): dev199580. Published online 2021 Sep 24. doi: 10.1242/dev.199580

PMCID:: PMC8497778

Abstract Article

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