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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699832.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67466603.

Dynamic Palmitoylation Regulates Trafficking of K Channel Interacting Protein 2 (KChIP2) across Multiple Subcellular Compartments in Cardiac Myocytes

Akshay Murthy, Samuel Workman, Min Jiang, Junping Hu, Ismat Sifa, Tytus Bernas, Wanchun Tang, Isabelle Deschenes, Gea-Ny Tseng

J Mol Cell Cardiol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: J Mol Cell Cardiol. 2019 Oct; 135: 1–9. Published online 2019 Jul 27. doi: 10.1016/j.yjmcc.2019.07.013

PMCID:: PMC6746660

Abstract Article PDF–3.1M

Select item 67299404.

KChIPs and Kv4 α Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain

Kenneth J. Rhodes, Karen I. Carroll, M. Amy Sung, Lisa C. Doliveira, Michael M. Monaghan, Sharon L. Burke, Brian W. Strassle, Lynn Buchwalder, Milena Menegola, Jie Cao, W. Frank An, James S. Trimmer

J Neurosci. 2004 Sep 8; 24(36): 7903–7915. doi: 10.1523/JNEUROSCI.0776-04.2004

PMCID:: PMC6729940

Abstract Article PDF–1.0M

Select item 64164245.

A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca²⁺ regulation of Kv4 channels

Jonathan G. Murphy, Dax A. Hoffman

J Biol Chem. 2019 Mar 8; 294(10): 3683–3695. Published online 2019 Jan 8. doi: 10.1074/jbc.RA118.006549

PMCID:: PMC6416424

Abstract Article PDF–4.8M

Select item 57920066.

Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons

Helena Prechtel, Sven Hartmann, Daniel Minge, Robert Bähring

PLoS One. 2018; 13(1): e0191911. Published online 2018 Jan 31. doi: 10.1371/journal.pone.0191911

PMCID:: PMC5792006

Abstract Article PDF–15M

Select item 55316117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 54952258.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 53389199.

KChIP2 is a core transcriptional regulator of cardiac excitability

Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes

eLife. 2017; 6: e17304. Published online 2017 Mar 6. doi: 10.7554/eLife.17304

PMCID:: PMC5338919

Abstract Article PDF–1.5M

Select item 492389110.

Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling

Sine V. Winther, Tomi Tuomainen, Rehannah Borup, Pasi Tavi, Gudrun Antoons, Morten B. Thomsen

Sci Rep. 2016; 6: 28760. Published online 2016 Jun 28. doi: 10.1038/srep28760

PMCID:: PMC4923891

Abstract Article PDF–1.3M

Select item 461721111.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 449459412.

Two novel Brugada syndrome-associated mutations increase K_V4.3 membrane expression and function

TAO YOU, WEIKE MAO, BENZHI CAI, FAQIAN LI, HAODONG XU

Int J Mol Med. 2015 Jul; 36(1): 309–315. Published online 2015 May 26. doi: 10.3892/ijmm.2015.2223

PMCID:: PMC4494594

Abstract Article PDF–737K

Select item 322575113.

The “structurally minimal” isoform KChIP2d modulates recovery of K_v4.3 N-terminal deletion mutant Δ2-39

Laura J Hovind, Donald L Campbell

Channels (Austin) 2011 May-Jun; 5(3): 225–227. Published online 2011 May 1. doi: 10.4161/chan.5.3.15313

PMCID:: PMC3225751

Abstract Article PDF–638K

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 315055115.

Transient Outward Current (I_to) Gain-of-Function Mutations in the KCND3-Encoded Kv4.3 Potassium Channel and Brugada Syndrome

John R. Giudicessi, Dan Ye, David J. Tester, Lia Crotti, Alessandra Mugione, Vladislav V. Nesterenko, Richard M. Albertson, Charles Antzelevitch, Peter J. Schwartz, Michael J. Ackerman

Heart Rhythm. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Heart Rhythm. 2011 Jul; 8(7): 1024–1032. Published online 2011 Feb 22. doi: 10.1016/j.hrthm.2011.02.021