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Items: 1 to 20 of 266

1.
Deciphering the role of SAMHD1 in endometrial cancer progression
Ping Qiang, Ying Chen, Yang Shao, Qicheng Deng, Songyuan Xu, Weipei Zhu
Biol Direct. 2024; 19: 89. Published online 2024 Oct 11. doi: 10.1186/s13062-024-00525-7
PMCID:
PMC11468744
ArticlePDF–7.8M
2.
Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, Felipe Diaz-Griffero
mBio. 2024 Sep; 15(9): e01958-24. Published online 2024 Aug 20. doi: 10.1128/mbio.01958-24
PMCID:
PMC11389391
ArticlePDF–2.7M
3.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
ArticlePDF–3.0M
4.
Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies
Jakub Chrustowicz, Dawafuti Sherpa, Jerry Li, Christine R. Langlois, Eleftheria C. Papadopoulou, D. Tung Vu, Laura A. Hehl, Özge Karayel, Viola Beier, Susanne von Gronau, Judith Müller, J. Rajan Prabu, Matthias Mann, Gary Kleiger, Arno F. Alpi, Brenda A. Schulman
Mol Cell. Author manuscript; available in PMC 2025 Jan 18.
Published in final edited form as: Mol Cell. 2024 Jan 18; 84(2): 293–308.e14. Published online 2023 Dec 18. doi: 10.1016/j.molcel.2023.11.027
PMCID:
PMC10843684
ArticlePDF–3.1M
5.
Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1
Benjamin Orris, Min Woo Sung, Shridhar Bhat, Yingrong Xu, Kevin W Huynh, Seungil Han, Darren C Johnson, Benedikt Bosbach, David J Shields, James T Stivers
Nucleic Acids Res. 2023 Dec 11; 51(22): 12443–12458. Published online 2023 Nov 1. doi: 10.1093/nar/gkad971
PMCID:
PMC10711556
ArticlePDF–2.4M
6.
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König
mBio. 2023 Sep-Oct; 14(5): e02252-23. Published online 2023 Oct 6. doi: 10.1128/mbio.02252-23
PMCID:
PMC10653793
ArticlePDF–2.5M
7.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
ArticlePDF–3.7M
8.
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma
Yiqing Cai, Xiaomin Chen, Tiange Lu, Xiaosheng Fang, Mengfei Ding, Zhuoya Yu, Shunfeng Hu, Jiarui Liu, Xiangxiang Zhou, Xin Wang
Int J Biol Sci. 2023; 19(14): 4627–4643. Published online 2023 Aug 28. doi: 10.7150/ijbs.85236
PMCID:
PMC10535696
ArticlePDF–7.5M
9.
SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection
Constanza E. Espada, Levent Sari, Michael P. Cahill, Hua Yang, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Milo M. Lin, Li Wu
J Biol Chem. 2023 Jul; 299(7): 104925. Published online 2023 Jun 14. doi: 10.1016/j.jbc.2023.104925
PMCID:
PMC10404699
ArticlePDF–3.3M
10.
C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains
Julia Jülg, Dieter Edbauer, Christian Behrends
EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895
PMCID:
PMC10398660
ArticlePDF–2.4M
11.
Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site
Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis
Nucleic Acids Res. 2023 Jul 21; 51(13): 7014–7024. Published online 2023 May 29. doi: 10.1093/nar/gkad447
PMCID:
PMC10359594
ArticlePDF–1.2M
12.
The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection
Hua Yang, Constanza E. Espada, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Li Wu
J Biol Chem. 2023 Jun; 299(6): 104750. Published online 2023 Apr 24. doi: 10.1016/j.jbc.2023.104750
PMCID:
PMC10318468
ArticlePDF–4.9M
13.
SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia
Richard J. Marrero, Xueyuan Cao, Huiyun Wu, Abdelrahman H. Elsayed, Jeffery M. Klco, Raul C. Ribeiro, Jeffrey E. Rubnitz, Xiaotu Ma, Soheil Meshinchi, Richard Aplenc, E. Anders Kolb, Rhonda E. Ries, Todd A. Alonzo, Stanley B. Pounds, Jatinder K. Lamba
Blood Adv. 2023 Jun 13; 7(11): 2538–2550. Published online 2023 Jan 24. doi: 10.1182/bloodadvances.2022009088
PMCID:
PMC10242642
ArticlePDF–708K
14.
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
Jingwei Liu, Tingting Zhou, Xiang Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Danni Li, Ling Ren, Fei Yi, Ying Zhang, Ziwei Li, Xiwen Wang, Chengsi Deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Songming Lu, Liangzi Cao, Yutong Xiao, Xiaoyu Song, Zhenning Wang, Chengzhong Xing, Liu Cao
Oncogene. 2023; 42(22): 1843–1856. Published online 2023 Apr 20. doi: 10.1038/s41388-023-02667-w
PMCID:
PMC10238270
ArticlePDF–6.2M
15.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
ArticlePDF–23M
16.
Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells
Kuen-Daw Tsai, Yi-Chao Lee, Bo-Yu Chen, Li-Syuan Wu, Shan-Yuan Liang, Ming-Yuan Liu, Yu-Wen Hung, Hui-Ling Hsu, Pei-Qi Chen, Jia-Ching Shieh, Yi-Ju Lee, Ting-Hui Lin
Int J Med Sci. 2023; 20(6): 810–817. Published online 2023 Apr 29. doi: 10.7150/ijms.78279
PMCID:
PMC10198147
ArticlePDF–1.5M
17.
SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion
Sunho An, Tam Thuy Lu Vo, Taekwon Son, Hoon Choi, Jinyoung Kim, Juyeon Lee, Byung Hoon Kim, Misun Choe, Eunyoung Ha, Young-Joon Surh, Kyu-Won Kim, Ji Hae Seo
Exp Mol Med. 2023 Apr; 55(4): 779–793. Published online 2023 Apr 3. doi: 10.1038/s12276-023-00961-x
PMCID:
PMC10167369
ArticlePDF–4.7M
18.
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
Lucía Gutiérrez-Chamorro, Eudald Felip, Adrià Bernat-Peguera, Ifeanyi Jude Ezeonwumelu, Iris Teruel, Anna Martínez-Cardús, Bonaventura Clotet, Eva Riveira-Muñoz, Margarita Romeo, Mireia Margelí, Ester Ballana
Front Immunol. 2023; 14: 1112761. Published online 2023 Feb 9. doi: 10.3389/fimmu.2023.1112761
PMCID:
PMC9948397
ArticlePDF–3.7M
19.
SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma
Yangyi Li, Yuke Gao, Xueping Jiang, Yajie Cheng, Jianguo Zhang, Liexi Xu, Xinyu Liu, Zhengrong Huang, Conghua Xie, Yan Gong
J Transl Med. 2022; 20: 628. Published online 2022 Dec 29. doi: 10.1186/s12967-022-03844-3
PMCID:
PMC9798699
ArticlePDF–13M
20.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
ArticlePDF–8.2M

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