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Items: 1 to 20 of 46

1.
Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans
Sun‐Young Bae, Sun‐Keun Choi, Kyung‐Rae Kim, Chang‐Shin Park, Sung‐Keun Lee, Hyung‐Keun Roh, Dong‐Woon Shin, Jae‐Eun Pie, Ze‐Hong Woo, Ju‐Hee Kang
Cancer Sci. 2006 Aug; 97(8): 774–779. Published online 2006 Jun 23. doi: 10.1111/j.1349-7006.2006.00241.x
PMCID:
PMC11160064
AbstractArticlePDF–137K
2.
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children
Yumi Cleary, Heidemarie Kletzl, Paul Grimsey, Katja Heinig, Kayode Ogungbenro, Hanna Elisabeth Silber Baumann, Nicolas Frey, Leon Aarons, Aleksandra Galetin, Michael Gertz
Clin Pharmacokinet. 2023; 62(6): 891–904. Published online 2023 May 6. doi: 10.1007/s40262-023-01241-7
PMCID:
PMC10256639
AbstractArticlePDF–2.1M
3.
Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes
Simona Alibrandi, Fabiana Nicita, Luigi Donato, Concetta Scimone, Carmela Rinaldi, Rosalia D’Angelo, Antonina Sidoti
Molecules. 2021 Nov; 26(22): 7045. Published online 2021 Nov 22. doi: 10.3390/molecules26227045
PMCID:
PMC8618768
AbstractArticlePDF–3.6M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
6.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
7.
Nicotine-N’-oxidation by flavin monooxygenase enzymes
Yadira X. Perez-Paramo, Gang Chen, Joseph H. Ashmore, Christy J. W. Watson, Shamema Nasrin, Jennifer Adams-Haduch, Renwei Wang, Yu-Tang Gao, Woon-Puay Koh, Jian-Min Yuan, Philip Lazarus
Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Feb 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Feb; 28(2): 311–320. Published online 2018 Oct 31. doi: 10.1158/1055-9965.EPI-18-0669
PMCID:
PMC6363832
AbstractArticlePDF–1.1M
8.
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
W. Zhu, J. A. Buffa, Z. Wang, M. Warrier, R. Schugar, D. M. Shih, N. Gupta, J. C. Gregory, E. Org, X. Fu, L. Li, J. A. DiDonato, A. J. Lusis, J. M. Brown, S. L. Hazen
J Thromb Haemost. Author manuscript; available in PMC 2019 Sep 1.
Published in final edited form as: J Thromb Haemost. 2018 Sep; 16(9): 1857–1872. Published online 2018 Aug 9. doi: 10.1111/jth.14234
PMCID:
PMC6156942
AbstractArticlePDF–2.1M
9.
Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver
Meijuan Xu, Deepak Kumar Bhatt, Catherine K. Yeung, Katrina G. Claw, Amarjit S. Chaudhry, Andrea Gaedigk, Robin E. Pearce, Ulrich Broeckel, Roger Gaedigk, Deborah A. Nickerson, Erin Schuetz, Allan E. Rettie, J. Steven Leeder, Kenneth E. Thummel, Bhagwat Prasad
J Pharmacol Exp Ther. 2017 Nov; 363(2): 265–274. Published online 2017 Nov. doi: 10.1124/jpet.117.243113
PMCID:
PMC5697103
AbstractArticlePDF–714K
10.
Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Ibrahim El-Serafi, Ylva Terelius, Manuchehr Abedi-Valugerdi, Seán Naughton, Maryam Saghafian, Ali Moshfegh, Jonas Mattsson, Zuzana Potácová, Moustapha Hassan
PLoS One. 2017; 12(11): e0187294. Published online 2017 Nov 9. doi: 10.1371/journal.pone.0187294
Correction in:
PLoS One. 2017; 12(12): e0190181.
PMCID:
PMC5679629
AbstractArticlePDF–3.3M
11.
Targeted sequencing identifies genetic polymorphisms of flavin‐containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American
Tian‐Xiao Zhang, Nancy L. Saccone, Laura J. Bierut, John P. Rice
Brain Behav. 2017 Apr; 7(4): e00651. Published online 2017 Mar 15. doi: 10.1002/brb3.651
PMCID:
PMC5390834
AbstractArticlePDF–476K
12.
Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers
Yong-Jun Tang, Kai Hu, Wei-Hua Huang, Chong-Zhi Wang, Zhi Liu, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan, Hong-Hao Zhou, Chun-Su Yuan
Biomed Res Int. 2017; 2017: 4189678. Published online 2017 Feb 26. doi: 10.1155/2017/4189678
PMCID:
PMC5346382
AbstractArticlePDF–1.0M
13.
Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients
Cassianne Robinson-Cohen, Richard Newitt, Danny D. Shen, Allan E. Rettie, Bryan R. Kestenbaum, Jonathan Himmelfarb, Catherine K. Yeung
PLoS One. 2016; 11(8): e0161074. Published online 2016 Aug 11. doi: 10.1371/journal.pone.0161074
PMCID:
PMC4981377
AbstractArticlePDF–496K
14.
Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
Yao Chen, Nicole R. Zane, Dhiren R. Thakker, Michael Zhuo Wang
Drug Metab Dispos. 2016 Jul; 44(7): 975–983. Published online 2016 Jul. doi: 10.1124/dmd.115.067538
PMCID:
PMC4931884
AbstractArticlePDF–1.6M
15.
Widespread expansion of protein interaction capabilities by alternative splicing
Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal
Cell. Author manuscript; available in PMC 2017 Feb 11.
Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029
PMCID:
PMC4882190
AbstractArticlePDF–1.9M
16.
Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors
Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, Toshio Kumai, Shinichi Kobayashi, F. Peter Guengerich, Hiroshi Yamazaki
Drug Metab Pharmacokinet. Author manuscript; available in PMC 2016 Feb 16.
Published in final edited form as: Drug Metab Pharmacokinet. 2009; 24(3): 218–225. doi: 10.2133/dmpk.24.218
PMCID:
PMC4755719
AbstractArticlePDF–910K
17.
Oxidative Stress-responsive Transcription Factor NRF2 is Not Indispensable For The Human Hepatic Flavin-Containing Monooxygenase-3 (FMO3) Gene Expression in HepG2 Cells
Swetha Rudraiah, Xinsheng Gu, Ronald N. Hines, José E. Manautou
Toxicol In Vitro. Author manuscript; available in PMC 2017 Mar 1.
Published in final edited form as: Toxicol In Vitro. 2016 Mar; 31: 54–59. Published online 2015 Nov 23. doi: 10.1016/j.tiv.2015.11.016
PMCID:
PMC4695222
AbstractArticlePDF–1.6M
18.
Emerging Roles of Flavin Monooxygenase 3 (FMO3) in Cholesterol Metabolism and Atherosclerosis
Rebecca C. Schugar, J. Mark Brown
Curr Opin Lipidol. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Curr Opin Lipidol. 2015 Oct; 26(5): 426–431. doi: 10.1097/MOL.0000000000000215
PMCID:
PMC4666514
AbstractArticlePDF–263K
19.
Effects upon in vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
Dr. A. Joseph Bloom, Dr. Sharon E. Murphy, Ms. Maribel Martinez, Dr. Linda B. von Weymarn, Dr. Laura J. Bierut, Dr. Alison Goate
Pharmacogenet Genomics. Author manuscript; available in PMC 2015 Sep 25.
Published in final edited form as: Pharmacogenet Genomics. 2013 Feb; 23(2): 62–68. doi: 10.1097/FPC.0b013e32835c3b48
PMCID:
PMC4583063
AbstractArticlePDF–292K
20.
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni, Song Yi, Mikko Taipale, Juan I. Fuxman Bass, Jasmin Coulombe-Huntington, Fan Yang, Jian Peng, Jochen Weile, Georgios I. Karras, Yang Wang, István A. Kovács, Atanas Kamburov, Irina Krykbaeva, Mandy H. Lam, George Tucker, Vikram Khurana, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Kourosh Salehi-Ashtiani, Luke J. Whitesell, Shamil Sunyaev, Bonnie Berger, Albert-László Barabási, Benoit Charloteaux, David E. Hill, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, Marc Vidal
Cell. Author manuscript; available in PMC 2016 Apr 23.
Published in final edited form as: Cell. 2015 Apr 23; 161(3): 647–660. doi: 10.1016/j.cell.2015.04.013
PMCID:
PMC4441215
AbstractArticlePDF–1.2M

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